315 related articles for article (PubMed ID: 33470442)
1. Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF.
Yamanaka S; Murai H; Saito D; Abe G; Tokunaga E; Iwasaki T; Takahashi H; Takeda H; Suzuki T; Shibata N; Tamura K; Sawasaki T
EMBO J; 2021 Feb; 40(4):e105375. PubMed ID: 33470442
[TBL] [Abstract][Full Text] [Related]
2. PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Shimizu N; Asatsuma-Okumura T; Yamamoto J; Yamaguchi Y; Handa H; Ito T
Commun Biol; 2021 Nov; 4(1):1277. PubMed ID: 34764413
[TBL] [Abstract][Full Text] [Related]
3. Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Furihata H; Yamanaka S; Honda T; Miyauchi Y; Asano A; Shibata N; Tanokura M; Sawasaki T; Miyakawa T
Nat Commun; 2020 Sep; 11(1):4578. PubMed ID: 32929090
[TBL] [Abstract][Full Text] [Related]
4. p63 is a cereblon substrate involved in thalidomide teratogenicity.
Asatsuma-Okumura T; Ando H; De Simone M; Yamamoto J; Sato T; Shimizu N; Asakawa K; Yamaguchi Y; Ito T; Guerrini L; Handa H
Nat Chem Biol; 2019 Nov; 15(11):1077-1084. PubMed ID: 31591562
[TBL] [Abstract][Full Text] [Related]
5. Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4.
Belair DG; Lu G; Waller LE; Gustin JA; Collins ND; Kolaja KL
Sci Rep; 2020 Feb; 10(1):2864. PubMed ID: 32071327
[TBL] [Abstract][Full Text] [Related]
6. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Matyskiela ME; Clayton T; Zheng X; Mayne C; Tran E; Carpenter A; Pagarigan B; McDonald J; Rolfe M; Hamann LG; Lu G; Chamberlain PP
Nat Struct Mol Biol; 2020 Apr; 27(4):319-322. PubMed ID: 32251415
[TBL] [Abstract][Full Text] [Related]
7. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
Gandhi AK; Kang J; Havens CG; Conklin T; Ning Y; Wu L; Ito T; Ando H; Waldman MF; Thakurta A; Klippel A; Handa H; Daniel TO; Schafer PH; Chopra R
Br J Haematol; 2014 Mar; 164(6):811-21. PubMed ID: 24328678
[TBL] [Abstract][Full Text] [Related]
8. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Sievers QL; Petzold G; Bunker RD; Renneville A; Słabicki M; Liddicoat BJ; Abdulrahman W; Mikkelsen T; Ebert BL; Thomä NH
Science; 2018 Nov; 362(6414):. PubMed ID: 30385546
[TBL] [Abstract][Full Text] [Related]
9. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES; Böhm K; Lydeard JR; Yang H; Stadler MB; Cavadini S; Nagel J; Serluca F; Acker V; Lingaraju GM; Tichkule RB; Schebesta M; Forrester WC; Schirle M; Hassiepen U; Ottl J; Hild M; Beckwith RE; Harper JW; Jenkins JL; Thomä NH
Nature; 2014 Aug; 512(7512):49-53. PubMed ID: 25043012
[TBL] [Abstract][Full Text] [Related]
10. SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.
Matyskiela ME; Couto S; Zheng X; Lu G; Hui J; Stamp K; Drew C; Ren Y; Wang M; Carpenter A; Lee CW; Clayton T; Fang W; Lu CC; Riley M; Abdubek P; Blease K; Hartke J; Kumar G; Vessey R; Rolfe M; Hamann LG; Chamberlain PP
Nat Chem Biol; 2018 Oct; 14(10):981-987. PubMed ID: 30190590
[TBL] [Abstract][Full Text] [Related]
11. Molecular mechanisms of cereblon-based drugs.
Asatsuma-Okumura T; Ito T; Handa H
Pharmacol Ther; 2019 Oct; 202():132-139. PubMed ID: 31202702
[TBL] [Abstract][Full Text] [Related]
12. Identification of a primary target of thalidomide teratogenicity.
Ito T; Ando H; Suzuki T; Ogura T; Hotta K; Imamura Y; Yamaguchi Y; Handa H
Science; 2010 Mar; 327(5971):1345-50. PubMed ID: 20223979
[TBL] [Abstract][Full Text] [Related]
13. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Akuffo AA; Alontaga AY; Metcalf R; Beatty MS; Becker A; McDaniel JM; Hesterberg RS; Goodheart WE; Gunawan S; Ayaz M; Yang Y; Karim MR; Orobello ME; Daniel K; Guida W; Yoder JA; Rajadhyaksha AM; Schönbrunn E; Lawrence HR; Lawrence NJ; Epling-Burnette PK
J Biol Chem; 2018 Apr; 293(16):6187-6200. PubMed ID: 29449372
[TBL] [Abstract][Full Text] [Related]
14. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.
Matyskiela ME; Zhu J; Baughman JM; Clayton T; Slade M; Wong HK; Danga K; Zheng X; Labow M; LeBrun L; Lu G; Chamberlain PP; Thompson JW
ACS Chem Biol; 2020 Dec; 15(12):3149-3158. PubMed ID: 33206504
[TBL] [Abstract][Full Text] [Related]
15. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME; Lu G; Ito T; Pagarigan B; Lu CC; Miller K; Fang W; Wang NY; Nguyen D; Houston J; Carmel G; Tran T; Riley M; Nosaka L; Lander GC; Gaidarova S; Xu S; Ruchelman AL; Handa H; Carmichael J; Daniel TO; Cathers BE; Lopez-Girona A; Chamberlain PP
Nature; 2016 Jul; 535(7611):252-7. PubMed ID: 27338790
[TBL] [Abstract][Full Text] [Related]
16. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.
Nguyen TV; Lee JE; Sweredoski MJ; Yang SJ; Jeon SJ; Harrison JS; Yim JH; Lee SG; Handa H; Kuhlman B; Jeong JS; Reitsma JM; Park CS; Hess S; Deshaies RJ
Mol Cell; 2016 Mar; 61(6):809-20. PubMed ID: 26990986
[TBL] [Abstract][Full Text] [Related]
17. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology.
Ito T; Yamaguchi Y; Handa H
Cell Chem Biol; 2021 Jul; 28(7):987-999. PubMed ID: 34033753
[TBL] [Abstract][Full Text] [Related]
18. Teratogenic effects of thalidomide: molecular mechanisms.
Ito T; Ando H; Handa H
Cell Mol Life Sci; 2011 May; 68(9):1569-79. PubMed ID: 21207098
[TBL] [Abstract][Full Text] [Related]
19. Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
Tateno S; Iida M; Fujii S; Suwa T; Katayama M; Tokuyama H; Yamamoto J; Ito T; Sakamoto S; Handa H; Yamaguchi Y
Sci Rep; 2020 Mar; 10(1):4012. PubMed ID: 32132601
[TBL] [Abstract][Full Text] [Related]
20. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.
Heim C; Pliatsika D; Mousavizadeh F; Bär K; Hernandez Alvarez B; Giannis A; Hartmann MD
J Med Chem; 2019 Jul; 62(14):6615-6629. PubMed ID: 31251063
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
