Terms: = Leukemia AND MDM2, HDM2, 4193, ENSG00000135679, HDMX, MGC71221, hdm2, Q00987
513 results:
1. Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia.
Wang K; Jiang M; Liu H; Meng C; Li M; Lu H
Bioorg Chem; 2024 Jun; 147():107319. PubMed ID: 38593529
[TBL] [Abstract] [Full Text] [Related]
2. Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease.
Scott MT; Liu W; Mitchell R; Clarke CJ; Kinstrie R; Warren F; Almasoudi H; Stevens T; Dunn K; Pritchard J; Drotar ME; Michie AM; Jørgensen HG; Higgins B; Copland M; Vetrie D
Nat Commun; 2024 Jan; 15(1):651. PubMed ID: 38246924
[TBL] [Abstract] [Full Text] [Related]
3. Review on novel toxicological effects and personalized health hazard in workers exposed to low doses of benzene.
Wang T; Cao Y; Xia Z; Christiani DC; Au WW
Arch Toxicol; 2024 Feb; 98(2):365-374. PubMed ID: 38142431
[TBL] [Abstract] [Full Text] [Related]
4. Exploring Thiazolopyridine AV25R: Unraveling of Biological Activities, Selective Anti-Cancer Properties and In Silico Target and Binding Prediction in Hematological Neoplasms.
Ladwig A; Gupta S; Ehlers P; Sekora A; Alammar M; Koczan D; Wolkenhauer O; Junghanss C; Langer P; Murua Escobar H
Molecules; 2023 Dec; 28(24):. PubMed ID: 38138609
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5. mdm2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate radiation-induced DNA damage in human B lymphocytes.
Chen Y; Gong Y; Qin H; Wei S; Wei Y; Yu Y; Lin X; Shuai P; Wang T; Guo C; Wang Q; Li G; Meng L; Yi L
Ecotoxicol Environ Saf; 2024 Jan; 270():115848. PubMed ID: 38134636
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6. Enhanced
Nishida Y; Ishizawa J; Ayoub E; Montoya RH; Ostermann LB; Muftuoglu M; Ruvolo VR; Patsilevas T; Scruggs DA; Khazaei S; Mak PY; Tao W; Carter BZ; Boettcher S; Ebert BL; Daver NG; Konopleva M; Seki T; Kojima K; Andreeff M
Sci Adv; 2023 Dec; 9(48):eadh1436. PubMed ID: 38019903
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7. A GPX4 non-enzymatic domain and mdm2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction.
Niu F; Yang R; Feng H; Liu Y; Liu R; Ma B
Biochem Biophys Res Commun; 2023 Dec; 684():149125. PubMed ID: 37897912
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8. Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia.
Johansson KB; Zimmerman MS; Dmytrenko IV; Gao F; Link DC
Leukemia; 2023 Dec; 37(12):2356-2366. PubMed ID: 37838759
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9. Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction.
Gasparoli L; Virely C; Tsakaneli A; Che N; Edwards D; Bartram J; Hubank M; Pal D; Heidenreich O; Martens JHA; De Boer J; Williams O
Haematologica; 2024 Apr; 109(4):1069-1081. PubMed ID: 37794795
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10. [Novel therapeutics in myeloproliferative neoplasms: beyond JAK inhibitors].
Edahiro Y
Rinsho Ketsueki; 2023; 64(9):970-980. PubMed ID: 37793873
[TBL] [Abstract] [Full Text] [Related]
11. Decrease of lncRNA MEG3 in Acute Myeloid leukemia Affected the Expression of p53 and mdm2.
Jia Y; He E; Peng J; Zhao M
Clin Lab; 2023 Sep; 69(9):. PubMed ID: 37702691
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12. ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.
Meredith DM; Cooley LD; Dubuc A; Morrissette J; Sussman RT; Nasrallah MP; Rathbun P; Yap KL; Wadhwani N; Bao L; Wolff DJ; Ida C; Sukhanova M; Horbinski C; Jennings LJ; Farooqi M; Gener M; Ginn K; Kam KL; Sasaki K; Kanagal-Shamanna R; Alexandrescu S; Brat D; Lu X
Mod Pathol; 2023 Nov; 36(11):100294. PubMed ID: 37532182
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13.
Aptullahoglu E; Wallis JP; Marr H; Marshall S; Bown N; Willmore E; Lunec J
Int J Mol Sci; 2023 Jul; 24(14):. PubMed ID: 37511096
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14. A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis.
Senapati J; Muftuoglu M; Ishizawa J; Abbas HA; Loghavi S; Borthakur G; Yilmaz M; Issa GC; Dara SI; Basyal M; Li L; Naqvi K; Pourebrahim R; Jabbour EJ; Kornblau SM; Short NJ; Pemmaraju N; Garcia-Manero G; Ravandi F; Khoury J; Daver N; Kantarjian HM; Andreeff M; DiNardo CD
Blood Cancer J; 2023 Jun; 13(1):101. PubMed ID: 37386016
[TBL] [Abstract] [Full Text] [Related]
15. Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.
Carter BZ; Mak PY; Muftuoglu M; Tao W; Ke B; Pei J; Bedoy AD; Ostermann LB; Nishida Y; Isgandarova S; Sobieski M; Nguyen N; Powell RT; Martinez-Moczygemba M; Stephan C; Basyal M; Pemmaraju N; Boettcher S; Ebert BL; Shpall EJ; Wallner B; Morgan RA; Karras GI; Moll UM; Andreeff M
Blood; 2023 Sep; 142(12):1056-1070. PubMed ID: 37339579
[TBL] [Abstract] [Full Text] [Related]
16. Design, Synthesis and Antitumor Activity of 1
Wang C; Zhu M; Long X; Wang Q; Wang Z; Ouyang G
Int J Mol Sci; 2023 May; 24(10):. PubMed ID: 37240028
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17. Heat shock factor 1 is a promising therapeutic target against adult T-cell leukemia.
Ishikawa C; Mori N
Med Oncol; 2023 May; 40(6):172. PubMed ID: 37165174
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18. Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia.
Huang Z; Zhou J; Jiang Y; Han Y; Wang X; Li F; Jiang S; Yu K; Zhang S
J Cell Mol Med; 2023 Jun; 27(12):1682-1696. PubMed ID: 37154878
[TBL] [Abstract] [Full Text] [Related]
19. Synthesis and biological evaluation of dual mdm2/XIAP inhibitors based on the tetrahydroquinoline scaffold.
Albadari N; Xie Y; Liu T; Wang R; Gu L; Zhou M; Wu Z; Li W
Eur J Med Chem; 2023 Jul; 255():115423. PubMed ID: 37130471
[TBL] [Abstract] [Full Text] [Related]
20. Epigenetic silencing of ZCCHC10 by the lncRNA SNHG1 promotes progression and venetoclax resistance of acute myeloid leukemia.
Zhou H; Zhang Q; Huang W; He C; Zhou C; Zhou J; Ning Y
Int J Oncol; 2023 May; 62(5):. PubMed ID: 37052262
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