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  • Title: [Allogeneic bone marrow transplantation for the treatment of Bruton disease].
    Author: Huang X, Shi H, Guo N, Lu D.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2002 Oct; 23(10):528-30. PubMed ID: 12482350.
    Abstract:
    OBJECTIVE: To explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease. METHODS: HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice. RESULTS: Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease. CONCLUSION: Stem cell transplantation is a choice for the treatment of Bruton disease.
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