Title: Epstein-Barr viral load assessment in immunocompetent patients with fulminant infectious mononucleosis. Author: van Laar JA, Buysse CM, Vossen AC, Hjálmarsson B, van Den Berg B, van Lom K, Deinum J. Journal: Arch Intern Med; 2002 Apr 08; 162(7):837-9. PubMed ID: 11926861. Abstract: We describe 2 immunocompetent adolescents with fulminant infectious mononucleosis and virus-associated hemophagocytosis. A new quantitative polymerase chain reaction revealed high serum Epstein-Barr virus DNA levels in these patients. One patient died with an increasing viral load not responding to corticosteroids followed by antiviral and intensified immunomodulatory treatment. The other patient received corticosteroids and acyclovir at diagnosis; her rapid recovery was heralded by a steep decline of viral load. We propose monitoring the clinical course of fulminant infectious mononucleosis in immunocompetent patients by Epstein-Barr virus DNA quantification and prompt corticosteroid and antiviral therapy when viral load is high.[Abstract] [Full Text] [Related] [New Search]
