Title: The role of estrogen therapy in postpartum psychiatric disorders: an update. Author: Gentile S. Journal: CNS Spectr; 2005 Dec; 10(12):944-52. PubMed ID: 16344831. Abstract: OBJECTIVES: The aim of this review is to assess and summarize the existing literature data about the efficacy of estrogen replacement therapy (ERT) in preventing and treating postpartum psychiatric disorders. METHODS: An extensive and unrestrictive computerized search (from 1970 to June 2005) on MEDLINE/PubMed, TOXNET, EMBASE, and Cochrane Databases was conducted with the following search terms: estradiol, estrogen-treatment, hormonal treatment, therapy, postpartum depression, postnatal depression, puerperal depression, postpartum blues, postpartum psychosis, lactation, and breastfeeding. RESULTS: In assessing available literature information about the role of ERT in preventing and treating puerperal psychiatric diseases, all reviewed studies were found to suffer from severe methodological limitations. CONCLUSION: Well-designed and strictly focused multicenter trials are warranted in order to firmly establish the effectiveness of ERT in puerperal psychiatric disorders.[Abstract] [Full Text] [Related] [New Search]
