Title: Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. Author: Lee JS, Yoo SS, Cho SY, Ock SM, Lim MK, Panych LP. Journal: Acta Psychiatr Scand; 2006 Jan; 113(1):64-7. PubMed ID: 16390372. Abstract: OBJECTIVE: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). METHOD: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7-14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. RESULTS: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. CONCLUSION: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.[Abstract] [Full Text] [Related] [New Search]
