BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

260 related articles for article (PubMed ID: 10037026)

  • 1. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
    Witthuhn BA; Williams MD; Kerawalla H; Uckun FM
    Leuk Lymphoma; 1999 Jan; 32(3-4):289-97. PubMed ID: 10037026
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
    Liu KD; Gaffen SL; Goldsmith MA; Greene WC
    Curr Biol; 1997 Nov; 7(11):817-26. PubMed ID: 9382798
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
    Kirken RA; Rui H; Malabarba MG; Howard OM; Kawamura M; O'Shea JJ; Farrar WL
    Cytokine; 1995 Oct; 7(7):689-700. PubMed ID: 8580378
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
    Malabarba MG; Kirken RA; Rui H; Koettnitz K; Kawamura M; O'Shea JJ; Kalthoff FS; Farrar WL
    J Biol Chem; 1995 Apr; 270(16):9630-7. PubMed ID: 7721895
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
    Zhou YJ; Magnuson KS; Cheng TP; Gadina M; Frucht DM; Galon J; Candotti F; Geahlen RL; Changelian PS; O'Shea JJ
    Mol Cell Biol; 2000 Jun; 20(12):4371-80. PubMed ID: 10825200
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins).
    Nielsen M; Svejgaard A; Röpke C; Nordahl M; Odum N
    Proc Natl Acad Sci U S A; 1995 Nov; 92(24):10995-9. PubMed ID: 7479924
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
    Zhu MH; Berry JA; Russell SM; Leonard WJ
    J Biol Chem; 1998 Apr; 273(17):10719-25. PubMed ID: 9553136
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
    Miyazaki T; Kawahara A; Fujii H; Nakagawa Y; Minami Y; Liu ZJ; Oishi I; Silvennoinen O; Witthuhn BA; Ihle JN
    Science; 1994 Nov; 266(5187):1045-7. PubMed ID: 7973659
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
    Beadling C; Guschin D; Witthuhn BA; Ziemiecki A; Ihle JN; Kerr IM; Cantrell DA
    EMBO J; 1994 Dec; 13(23):5605-15. PubMed ID: 7988557
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.
    Fujitani Y; Hibi M; Fukada T; Takahashi-Tezuka M; Yoshida H; Yamaguchi T; Sugiyama K; Yamanaka Y; Nakajima K; Hirano T
    Oncogene; 1997 Feb; 14(7):751-61. PubMed ID: 9047382
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
    Malabarba MG; Rui H; Deutsch HH; Chung J; Kalthoff FS; Farrar WL; Kirken RA
    Biochem J; 1996 Nov; 319 ( Pt 3)(Pt 3):865-72. PubMed ID: 8920992
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Convergence of signaling transduced by prolactin (PRL)/cytokine chimeric receptors on PRL-responsive gene transcription.
    Ferrag F; Chiarenza A; Goffin V; Kelly PA
    Mol Endocrinol; 1996 Apr; 10(4):451-60. PubMed ID: 8721989
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.
    Nelson BH; McIntosh BC; Rosencrans LL; Greenberg PD
    Proc Natl Acad Sci U S A; 1997 Mar; 94(5):1878-83. PubMed ID: 9050873
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
    Cacalano NA; Migone TS; Bazan F; Hanson EP; Chen M; Candotti F; O'Shea JJ; Johnston JA
    EMBO J; 1999 Mar; 18(6):1549-58. PubMed ID: 10075926
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.
    Yu CR; Lin JX; Fink DW; Akira S; Bloom ET; Yamauchi A
    J Immunol; 1996 Jul; 157(1):126-37. PubMed ID: 8683106
    [TBL] [Abstract][Full Text] [Related]  

  • 16. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase.
    Sharfe N; Dadi HK; Roifman CM
    Blood; 1995 Sep; 86(6):2077-85. PubMed ID: 7662955
    [TBL] [Abstract][Full Text] [Related]  

  • 17. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
    Wang LH; Kirken RA; Erwin RA; Yu CR; Farrar WL
    J Immunol; 1999 Apr; 162(7):3897-904. PubMed ID: 10201908
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide.
    Wang R; Griffin PR; Small EC; Thompson JE
    Arch Biochem Biophys; 2003 Feb; 410(1):7-15. PubMed ID: 12559972
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.
    Yu CL; Burakoff SJ
    J Biol Chem; 1997 May; 272(22):14017-20. PubMed ID: 9162019
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
    Murata T; Noguchi PD; Puri RK
    J Biol Chem; 1995 Dec; 270(51):30829-36. PubMed ID: 8530527
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.