These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 10066888)

  • 21. Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.
    Attard G; Reid AH; Olmos D; de Bono JS
    Cancer Res; 2009 Jun; 69(12):4937-40. PubMed ID: 19509232
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
    Handratta VD; Vasaitis TS; Njar VC; Gediya LK; Kataria R; Chopra P; Newman D; Farquhar R; Guo Z; Qiu Y; Brodie AM
    J Med Chem; 2005 Apr; 48(8):2972-84. PubMed ID: 15828836
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
    Clement OO; Freeman CM; Hartmann RW; Handratta VD; Vasaitis TS; Brodie AM; Njar VC
    J Med Chem; 2003 Jun; 46(12):2345-51. PubMed ID: 12773039
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
    Hille UE; Hu Q; Vock C; Negri M; Bartels M; Müller-Vieira U; Lauterbach T; Hartmann RW
    Eur J Med Chem; 2009 Jul; 44(7):2765-75. PubMed ID: 19211174
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
    Yamaoka M; Hara T; Hitaka T; Kaku T; Takeuchi T; Takahashi J; Asahi S; Miki H; Tasaka A; Kusaka M
    J Steroid Biochem Mol Biol; 2012 Apr; 129(3-5):115-28. PubMed ID: 22249003
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Inhibitors of steroidal cytochrome p450 enzymes as targets for drug development.
    Baston E; Leroux FR
    Recent Pat Anticancer Drug Discov; 2007 Jan; 2(1):31-58. PubMed ID: 18221052
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Abiraterone acetate, a first-in-class CYP17 inhibitor, establishes a new treatment paradigm in castration-resistant prostate cancer.
    Bedoya DJ; Mitsiades N
    Expert Rev Anticancer Ther; 2012 Jan; 12(1):1-3. PubMed ID: 22149426
    [No Abstract]   [Full Text] [Related]  

  • 28. CYP17 inhibition as a hormonal strategy for prostate cancer.
    Reid AH; Attard G; Barrie E; de Bono JS
    Nat Clin Pract Urol; 2008 Nov; 5(11):610-20. PubMed ID: 18985049
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.
    Leroux F
    Curr Med Chem; 2005; 12(14):1623-9. PubMed ID: 16022662
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.
    Pinto-Bazurco Mendieta MA; Negri M; Jagusch C; Müller-Vieira U; Lauterbach T; Hartmann RW
    J Med Chem; 2008 Aug; 51(16):5009-18. PubMed ID: 18672868
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Genetics, structure, function, mode of actions and role in cancer development of CYP17.
    Sushko TA; Gilep AA; Usanov SA
    Anticancer Agents Med Chem; 2014 Jan; 14(1):66-76. PubMed ID: 24007292
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer.
    Eichholz A; Ferraldeschi R; Attard G; de Bono JS
    Mol Cell Endocrinol; 2012 Sep; 360(1-2):68-75. PubMed ID: 21986558
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis.
    Nnane IP; Long BJ; Ling YZ; Grigoryev DN; Brodie AM
    Br J Cancer; 2000 Jul; 83(1):74-82. PubMed ID: 10883671
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.
    Hu Q; Jagusch C; Hille UE; Haupenthal J; Hartmann RW
    J Med Chem; 2010 Aug; 53(15):5749-58. PubMed ID: 20684610
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Androgen synthesis in a songbird: a study of cyp17 (17alpha-hydroxylase/C17,20-lyase) activity in the zebra finch.
    Schlinger BA; Lane NI; Grisham W; Thompson L
    Gen Comp Endocrinol; 1999 Jan; 113(1):46-58. PubMed ID: 9882543
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
    Moreira VM; Vasaitis TS; Njar VC; Salvador JA
    Steroids; 2007 Dec; 72(14):939-48. PubMed ID: 17884122
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.
    Long BJ; Grigoryev DN; Nnane IP; Liu Y; Ling YZ; Brodie AM
    Cancer Res; 2000 Dec; 60(23):6630-40. PubMed ID: 11118046
    [TBL] [Abstract][Full Text] [Related]  

  • 38. [Advances in the study of steroidal inhibitors of cytochrome P45017alpha].
    Du JJ; Chen HL; Li YC
    Yao Xue Xue Bao; 2013 Jan; 48(1):25-31. PubMed ID: 23600137
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo.
    Li Y; Liang XY; Wei LN; Xiong YL; Yang X; Shi HG; Yang ZH
    Reprod Biol Endocrinol; 2009 Jul; 7():73. PubMed ID: 19615041
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats.
    Hara T; Kouno J; Kaku T; Takeuchi T; Kusaka M; Tasaka A; Yamaoka M
    J Steroid Biochem Mol Biol; 2013 Mar; 134():80-91. PubMed ID: 23146910
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.