164 related articles for article (PubMed ID: 10089309)
1. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
Mochalkin I; Tulinsky A
Acta Crystallogr D Biol Crystallogr; 1999 Apr; 55(Pt 4):785-93. PubMed ID: 10089309
[TBL] [Abstract][Full Text] [Related]
2. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Vijayalakshmi J; Padmanabhan KP; Mann KG; Tulinsky A
Protein Sci; 1994 Dec; 3(12):2254-71. PubMed ID: 7756983
[TBL] [Abstract][Full Text] [Related]
3. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
Féthière J; Tsuda Y; Coulombe R; Konishi Y; Cygler M
Protein Sci; 1996 Jun; 5(6):1174-83. PubMed ID: 8762149
[TBL] [Abstract][Full Text] [Related]
4. Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Krishnan R; Mochalkin I; Arni R; Tulinsky A
Acta Crystallogr D Biol Crystallogr; 2000 Mar; 56(Pt 3):294-303. PubMed ID: 10713516
[TBL] [Abstract][Full Text] [Related]
5. Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
Tabernero L; Chang CY; Ohringer SL; Lau WF; Iwanowicz EJ; Han WC; Wang TC; Seiler SM; Roberts DG; Sack JS
J Mol Biol; 1995 Feb; 246(1):14-20. PubMed ID: 7853394
[TBL] [Abstract][Full Text] [Related]
6. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
7. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
Skrzypczak-Jankun E; Carperos VE; Ravichandran KG; Tulinsky A; Westbrook M; Maraganore JM
J Mol Biol; 1991 Oct; 221(4):1379-93. PubMed ID: 1942057
[TBL] [Abstract][Full Text] [Related]
8. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
Bhunia SS; Roy KK; Saxena AK
J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
[TBL] [Abstract][Full Text] [Related]
9. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
De Simone G; Lombardi A; Galdiero S; Nastri F; Della Morte R; Staiano N; Pedone C; Bolognesi M; Pavone V
Protein Sci; 1998 Feb; 7(2):243-53. PubMed ID: 9521099
[TBL] [Abstract][Full Text] [Related]
10. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
Qiu X; Padmanabhan KP; Carperos VE; Tulinsky A; Kline T; Maraganore JM; Fenton JW
Biochemistry; 1992 Dec; 31(47):11689-97. PubMed ID: 1445905
[TBL] [Abstract][Full Text] [Related]
11. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Skordalakes E; Elgendy S; Goodwin CA; Green D; Scully MF; Kakkar VV; Freyssinet JM; Dodson G; Deadman JJ
Biochemistry; 1998 Oct; 37(41):14420-7. PubMed ID: 9772168
[TBL] [Abstract][Full Text] [Related]
12. Refined structure of the hirudin-thrombin complex.
Rydel TJ; Tulinsky A; Bode W; Huber R
J Mol Biol; 1991 Sep; 221(2):583-601. PubMed ID: 1920434
[TBL] [Abstract][Full Text] [Related]
13. The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin.
Wu TP; Yee V; Tulinsky A; Chrusciel RA; Nakanishi H; Shen R; Priebe C; Kahn M
Protein Eng; 1993 Jul; 6(5):471-8. PubMed ID: 8415574
[TBL] [Abstract][Full Text] [Related]
14. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
Ganesh V; Lee AY; Clardy J; Tulinsky A
Protein Sci; 1996 May; 5(5):825-35. PubMed ID: 8732754
[TBL] [Abstract][Full Text] [Related]
15. Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Matthews JH; Krishnan R; Costanzo MJ; Maryanoff BE; Tulinsky A
Biophys J; 1996 Nov; 71(5):2830-9. PubMed ID: 8913620
[TBL] [Abstract][Full Text] [Related]
16. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
Nardini M; Pesce A; Rizzi M; Casale E; Ferraccioli R; Balliano G; Milla P; Ascenzi P; Bolognesi M
J Mol Biol; 1996 May; 258(5):851-9. PubMed ID: 8637015
[TBL] [Abstract][Full Text] [Related]
17. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Zdanov A; Wu S; DiMaio J; Konishi Y; Li Y; Wu X; Edwards BF; Martin PD; Cygler M
Proteins; 1993 Nov; 17(3):252-65. PubMed ID: 8272424
[TBL] [Abstract][Full Text] [Related]
18. Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Brandstetter H; Turk D; Hoeffken HW; Grosse D; Stürzebecher J; Martin PD; Edwards BF; Bode W
J Mol Biol; 1992 Aug; 226(4):1085-99. PubMed ID: 1518046
[TBL] [Abstract][Full Text] [Related]
19. Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
Chen Z; Li Y; Mulichak AM; Lewis SD; Shafer JA
Arch Biochem Biophys; 1995 Sep; 322(1):198-203. PubMed ID: 7574675
[TBL] [Abstract][Full Text] [Related]
20. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
