119 related articles for article (PubMed ID: 1009125)
1. Inhibition of papain by isothiocyanates.
Tang CS; Tang WJ
Biochim Biophys Acta; 1976 Dec; 452(2):510-20. PubMed ID: 1009125
[TBL] [Abstract][Full Text] [Related]
2. Interactions of derivatives of guanidinophenylglycine and guanidinophenylalanine with trypsin and related enzymes.
Tsunematsu H; Makisumi S
J Biochem; 1980 Dec; 88(6):1773-83. PubMed ID: 7462203
[TBL] [Abstract][Full Text] [Related]
3. Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.
Topham CM; Salih E; Frazao C; Kowlessur D; Overington JP; Thomas M; Brocklehurst SM; Patel M; Thomas EW; Brocklehurst K
Biochem J; 1991 Nov; 280 ( Pt 1)(Pt 1):79-92. PubMed ID: 1741760
[TBL] [Abstract][Full Text] [Related]
4. Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain.
Thomas MP; Topham CM; Kowlessur D; Mellor GW; Thomas EW; Whitford D; Brocklehurst K
Biochem J; 1994 Jun; 300 ( Pt 3)(Pt 3):805-20. PubMed ID: 8010964
[TBL] [Abstract][Full Text] [Related]
5. Kinetics of the hydrolysis of N-benzoyl-L-serine methyl ester catalysed by bromelain and by papain. Analysis of modifier mechanisms by lattice nomography, computational methods of parameter evaluation for substrate-activated catalyses and consequences of postulated non-productive binding in bromelain- and papain-catalysed hydrolyses.
Wharton CW; Cornish-Bowden A; Brocklehurst K; Crook EM
Biochem J; 1974 Aug; 141(2):365-381. PubMed ID: 4455211
[TBL] [Abstract][Full Text] [Related]
6. Subsite differences between the active centres of papaya peptidase A and papain as revealed by affinity chromatography. Purification of papaya peptidase A by ionic-strength-dependent affinity adsorption on an immobilized peptide inhibitor of papain.
Schack P; Kaarsholm NC
Biochem J; 1984 May; 219(3):727-33. PubMed ID: 6378179
[TBL] [Abstract][Full Text] [Related]
7. Covalent chromatography. Preparation of fully active papain from dried papaya latex.
Brocklehurst K; Carlsson J; Kierstan MP; Crook EM
Biochem J; 1973 Jul; 133(3):573-84. PubMed ID: 4733241
[TBL] [Abstract][Full Text] [Related]
8. A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods.
Baines BS; Brocklehurst K
Biochem J; 1979 Feb; 177(2):541-8. PubMed ID: 435250
[TBL] [Abstract][Full Text] [Related]
9. Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe studies targeted on the catalytic-site thiol group and its immediate microenvironment.
Salih E; Malthouse JP; Kowlessur D; Jarvis M; O'Driscoll M; Brocklehurst K
Biochem J; 1987 Oct; 247(1):181-93. PubMed ID: 2825655
[TBL] [Abstract][Full Text] [Related]
10. A marked gradation in active-centre properties in the cysteine proteinases revealed by neutral and anionic reactivity probes. Reactivity characteristics of the thiol groups of actinidin, ficin, papain and papaya peptidase A towards 4,4'-dipyridyl disulphide and 5,5'-dithiobis-(2-nitrobenzoate) dianion.
Brocklehurst K; Mushiri SM; Patel G; Willenbrock F
Biochem J; 1983 Mar; 209(3):873-9. PubMed ID: 6347181
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of papain with 2-benzyl-3,4-epoxybutanoic acid esters. Mechanistic and stereochemical probe for cysteine protease catalysis.
Kim DH; Jin Y; Ryu CH
Bioorg Med Chem; 1997 Nov; 5(11):2103-8. PubMed ID: 9416427
[TBL] [Abstract][Full Text] [Related]
12. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates.
Smith TJ; Guo ZY; Thomas PE; Chung FL; Morse MA; Elkind K; Yang CS
Cancer Res; 1990 Nov; 50(21):6817-22. PubMed ID: 2208146
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationships for inhibition of papain by peptide Michael acceptors.
Liu S; Hanzlik RP
J Med Chem; 1992 Mar; 35(6):1067-75. PubMed ID: 1552501
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of papain by N-ethylmaleimide.
Brubacher LJ; Glick BR
Biochemistry; 1974 Feb; 13(5):915-20. PubMed ID: 4813371
[No Abstract] [Full Text] [Related]
15. Characterization of papaya peptidase A as a cysteine proteinase of Carica papaya L. with active-centre properties that differ from those of papain by using 2,2'-dipyridyl disulphide and 4-chloro-7-nitrobenzofurazan as reactivity probes. Use of two-protonic-state electrophiles in the identification of catalytic-site thiol groups.
Baines BS; Brocklehurst K
Biochem J; 1982 Jul; 205(1):205-11. PubMed ID: 6751321
[TBL] [Abstract][Full Text] [Related]
16. Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity-probe kinetics, steady-state kinetics and resonance Raman spectroscopy of some dithioacyl derivatives.
Baines BS; Brocklehurst K; Carey PR; Jarvis M; Salih E; Storer AC
Biochem J; 1986 Jan; 233(1):119-29. PubMed ID: 3513753
[TBL] [Abstract][Full Text] [Related]
17. A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.
Templeton W; Kowlessur D; Thomas EW; Topham CM; Brocklehurst K
Biochem J; 1990 Mar; 266(3):645-51. PubMed ID: 2327953
[TBL] [Abstract][Full Text] [Related]
18. Reactions of papain and of low-molecular-weight thiols with some aromatic disulphides. 2,2'-Dipyridyl disulphide as a convenient active-site titrant for papain even in the presence of other thiols.
Brocklehurst K; Little G
Biochem J; 1973 May; 133(1):67-80. PubMed ID: 4721623
[TBL] [Abstract][Full Text] [Related]
19. Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probe.
Brocklehurst K; Kowlessur D; Patel G; Templeton W; Quigley K; Thomas EW; Wharton CW; Willenbrock F; Szawelski RJ
Biochem J; 1988 Mar; 250(3):761-72. PubMed ID: 2839145
[TBL] [Abstract][Full Text] [Related]
20. Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity probe.
Mellor GW; Thomas EW; Topham CM; Brocklehurst K
Biochem J; 1993 Feb; 290 ( Pt 1)(Pt 1):289-96. PubMed ID: 8439297
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
