BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

690 related articles for article (PubMed ID: 10101027)

  • 1. Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
    Alhonen L; Pietilä M; Halmekytö M; Kramer DL; Jänne J; Porter CW
    Mol Pharmacol; 1999 Apr; 55(4):693-8. PubMed ID: 10101027
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse.
    Uimari A; Merentie M; Sironen R; Pirnes-Karhu S; Peräniemi S; Alhonen L
    Amino Acids; 2012 Feb; 42(2-3):461-71. PubMed ID: 21814793
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
    Porter CW; Bernacki RJ; Miller J; Bergeron RJ
    Cancer Res; 1993 Feb; 53(3):581-6. PubMed ID: 8425191
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
    Suppola S; Pietilä M; Parkkinen JJ; Korhonen VP; Alhonen L; Halmekytö M; Porter CW; Jänne J
    Biochem J; 1999 Mar; 338 ( Pt 2)(Pt 2):311-6. PubMed ID: 10024505
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of polyamines, polyamine analogs, and inhibitors of protein synthesis on spermidine-spermine N1-acetyltransferase gene expression.
    Fogel-Petrovic M; Vujcic S; Brown PJ; Haddox MK; Porter CW
    Biochemistry; 1996 Nov; 35(45):14436-44. PubMed ID: 8916930
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
    Alhonen L; Karppinen A; Uusi-Oukari M; Vujcic S; Korhonen VP; Halmekytö M; Kramer DL; Hines R; Jänne J; Porter CW
    J Biol Chem; 1998 Jan; 273(4):1964-9. PubMed ID: 9442032
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
    Porter CW; Ganis B; Libby PR; Bergeron RJ
    Cancer Res; 1991 Jul; 51(14):3715-20. PubMed ID: 2065327
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.
    Jiang R; Choi W; Khan A; Hess K; Gerner EW; Casero RA; Yung WK; Hamilton SR; Zhang W
    Int J Oncol; 2007 Aug; 31(2):431-40. PubMed ID: 17611701
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
    Niiranen K; Keinänen TA; Pirinen E; Heikkinen S; Tusa M; Fatrai S; Suppola S; Pietilä M; Uimari A; Laakso M; Alhonen L; Jänne J
    J Cell Mol Med; 2006; 10(4):933-45. PubMed ID: 17125596
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines.
    Stanic' I; Facchini A; Borzì RM; Stefanelli C; Flamigni F
    J Cell Physiol; 2009 Apr; 219(1):109-16. PubMed ID: 19097065
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Small interfering RNA suppression of polyamine analog-induced spermidine/spermine n1-acetyltransferase.
    Chen Y; Kramer DL; Jell J; Vujcic S; Porter CW
    Mol Pharmacol; 2003 Nov; 64(5):1153-9. PubMed ID: 14573765
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
    Gabrielson E; Tully E; Hacker A; Pegg AE; Davidson NE; Casero RA
    Cancer Chemother Pharmacol; 2004 Aug; 54(2):122-6. PubMed ID: 15138709
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
    Porter CW; Ganis B; Rustum Y; Wrzosek C; Kramer DL; Bergeron RJ
    Cancer Res; 1994 Nov; 54(22):5917-24. PubMed ID: 7954423
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.
    Suppola S; Heikkinen S; Parkkinen JJ; Uusi-Oukari M; Korhonen VP; Keinänen T; Alhonen L; Jänne J
    Biochem J; 2001 Sep; 358(Pt 2):343-8. PubMed ID: 11513732
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells.
    Libby PR; Henderson M; Bergeron RJ; Porter CW
    Cancer Res; 1989 Nov; 49(22):6226-31. PubMed ID: 2804970
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
    Hector S; Porter CW; Kramer DL; Clark K; Prey J; Kisiel N; Diegelman P; Chen Y; Pendyala L
    Mol Cancer Ther; 2004 Jul; 3(7):813-22. PubMed ID: 15252142
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
    Bernacki RJ; Oberman EJ; Seweryniak KE; Atwood A; Bergeron RJ; Porter CW
    Clin Cancer Res; 1995 Aug; 1(8):847-57. PubMed ID: 9816054
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential effects of the spermine analog, N1, N12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes.
    Shappell NW; Miller JT; Bergeron RJ; Porter CW
    Anticancer Res; 1992; 12(4):1083-9. PubMed ID: 1503400
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
    Hector S; Tummala R; Kisiel ND; Diegelman P; Vujcic S; Clark K; Fakih M; Kramer DL; Porter CW; Pendyala L
    Cancer Chemother Pharmacol; 2008 Aug; 62(3):517-27. PubMed ID: 17987291
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
    Alhonen L; Parkkinen JJ; Keinanen T; Sinervirta R; Herzig KH; Jänne J
    Proc Natl Acad Sci U S A; 2000 Jul; 97(15):8290-5. PubMed ID: 10880565
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 35.