297 related articles for article (PubMed ID: 10197622)
1. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
Xu-Welliver M; Leitão J; Kanugula S; Pegg AE
Cancer Res; 1999 Apr; 59(7):1514-9. PubMed ID: 10197622
[TBL] [Abstract][Full Text] [Related]
2. Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.
Xu-Welliver M; Kanugula S; Pegg AE
Cancer Res; 1998 May; 58(9):1936-45. PubMed ID: 9581836
[TBL] [Abstract][Full Text] [Related]
3. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
Loktionova NA; Xu-Welliver M; Crone TM; Kanugula S; Pegg AE
Biochem Pharmacol; 1999 Jul; 58(2):237-44. PubMed ID: 10423163
[TBL] [Abstract][Full Text] [Related]
4. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.
Xu-Welliver M; Leitão J; Kanugula S; Meehan WJ; Pegg AE
Biochem Pharmacol; 1999 Oct; 58(8):1279-85. PubMed ID: 10487529
[TBL] [Abstract][Full Text] [Related]
5. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
Xu-Welliver M; Kanugula S; Loktionova NA; Crone TM; Pegg AE
Biochem J; 2000 Apr; 347(Pt 2):527-34. PubMed ID: 10749683
[TBL] [Abstract][Full Text] [Related]
6. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
Goodtzova K; Kanugula S; Edara S; Pegg AE
Biochemistry; 1998 Sep; 37(36):12489-95. PubMed ID: 9730821
[TBL] [Abstract][Full Text] [Related]
7. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Cai Y; Wu MH; Xu-Welliver M; Pegg AE; Ludeman SM; Dolan ME
Cancer Res; 2000 Oct; 60(19):5464-9. PubMed ID: 11034089
[TBL] [Abstract][Full Text] [Related]
8. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
Davis BM; Roth JC; Liu L; Xu-Welliver M; Pegg AE; Gerson SL
Hum Gene Ther; 1999 Nov; 10(17):2769-78. PubMed ID: 10584923
[TBL] [Abstract][Full Text] [Related]
9. Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
Crone TM; Goodtzova K; Edara S; Pegg AE
Cancer Res; 1994 Dec; 54(23):6221-7. PubMed ID: 7954470
[TBL] [Abstract][Full Text] [Related]
10. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
Mijal RS; Thomson NM; Fleischer NL; Pauly GT; Moschel RC; Kanugula S; Fang Q; Pegg AE; Peterson LA
Chem Res Toxicol; 2004 Mar; 17(3):424-34. PubMed ID: 15025514
[TBL] [Abstract][Full Text] [Related]
11. Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
Wu MH; Lohrbach KE; Olopade OI; Kokkinakis DM; Friedman HS; Dolan ME
Clin Cancer Res; 1999 Jan; 5(1):209-13. PubMed ID: 9918221
[TBL] [Abstract][Full Text] [Related]
12. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L; Watanabe K; Fang Q; Williams KM; Guengerich FP; Pegg AE
Chem Res Toxicol; 2007 Jan; 20(1):155-63. PubMed ID: 17226938
[TBL] [Abstract][Full Text] [Related]
13. A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
Crone TM; Pegg AE
Cancer Res; 1993 Oct; 53(20):4750-3. PubMed ID: 8402653
[TBL] [Abstract][Full Text] [Related]
14. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
Loktionova NA; Pegg AE
Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
[TBL] [Abstract][Full Text] [Related]
15. Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine.
Gerson SL; Schupp J; Liu L; Pegg AE; Srinivasen S
Clin Cancer Res; 1999 Mar; 5(3):521-4. PubMed ID: 10100702
[TBL] [Abstract][Full Text] [Related]
16. Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.
Edara S; Kanugula S; Pegg AE
Carcinogenesis; 1999 Jan; 20(1):103-8. PubMed ID: 9934856
[TBL] [Abstract][Full Text] [Related]
17. Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
Liu L; Schwartz S; Davis BM; Gerson SL
Cancer Res; 2002 Jun; 62(11):3070-6. PubMed ID: 12036916
[TBL] [Abstract][Full Text] [Related]
18. Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.
Xu-Welliver M; Pegg AE
Biochem J; 2000 Apr; 347(Pt 2):519-26. PubMed ID: 10749682
[TBL] [Abstract][Full Text] [Related]
19. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
Pegg AE; Kanugula S; Edara S; Pauly GT; Moschel RC; Goodtzova K
J Biol Chem; 1998 May; 273(18):10863-7. PubMed ID: 9556560
[TBL] [Abstract][Full Text] [Related]
20. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
Lukash LL; Boldt J; Pegg AE; Dolan ME; Maher VM; McCormick JJ
Mutat Res; 1991; 250(1-2):397-409. PubMed ID: 1944354
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]