121 related articles for article (PubMed ID: 10201829)
21. Structure-activity relationships of new NAPAP-analogs.
Steinmetzer T; Schweinitz A; Künzel S; Wikström P; Hauptmann J; Stürzebecher J
J Enzyme Inhib; 2001; 16(3):241-9. PubMed ID: 11697044
[TBL] [Abstract][Full Text] [Related]
22. Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors.
Zhao Z; Arnaiz DO; Griedel B; Sakata S; Dallas JL; Whitlow M; Trinh L; Post J; Liang A; Morrissey MM; Shaw KJ
Bioorg Med Chem Lett; 2000 May; 10(9):963-6. PubMed ID: 10853669
[TBL] [Abstract][Full Text] [Related]
23. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Phillips GB; Buckman BO; Davey DD; Eagen KA; Guilford WJ; Hinchman J; Ho E; Koovakkat S; Liang A; Light DR; Mohan R; Ng HP; Post JM; Shaw KJ; Smith D; Subramanyam B; Sullivan ME; Trinh L; Vergona R; Walters J; White K; Whitlow M; Wu S; Xu W; Morrissey MM
J Med Chem; 1998 Sep; 41(19):3557-62. PubMed ID: 9733480
[No Abstract] [Full Text] [Related]
24. Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
Supuran CT; Scozzafava A; Briganti F; Clare BW
J Med Chem; 2000 May; 43(9):1793-806. PubMed ID: 10794696
[TBL] [Abstract][Full Text] [Related]
25. Synthesis and biological activity of dipeptides containing S-hexylcysteine.
Bruzgo I; Midura-Nowaczek K
Acta Pol Pharm; 2007; 64(5):479-82. PubMed ID: 18540170
[No Abstract] [Full Text] [Related]
26. Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin.
Geratz JD; Whitmore AC
J Med Chem; 1973 Sep; 16(9):970-5. PubMed ID: 4795664
[No Abstract] [Full Text] [Related]
27. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
Krishnan R; Zhang E; Hakansson K; Arni RK; Tulinsky A; Lim-Wilby MS; Levy OE; Semple JE; Brunck TK
Biochemistry; 1998 Sep; 37(35):12094-103. PubMed ID: 9724521
[TBL] [Abstract][Full Text] [Related]
28. Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position.
Obreza A; Stegnar M; Urleb U
Pharmazie; 2004 Sep; 59(9):659-67. PubMed ID: 15497744
[TBL] [Abstract][Full Text] [Related]
29. Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
Arnaiz DO; Zhao Z; Liang A; Trinh L; Witlow M; Koovakkat SK; Shaw KJ
Bioorg Med Chem Lett; 2000 May; 10(9):957-61. PubMed ID: 10853668
[TBL] [Abstract][Full Text] [Related]
30. Inhibition of bovine beta-trypsin, human alpha-thrombin and porcine pancreatic beta-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: thermodynamic and molecular modeling study.
Menegatti E; Ferroni R; Nastruzzi C; Bortolotti F; Scalia S; Amiconi G; Bolognesi M; Coletta M; Onesti S; Fruttero R
Farmaco; 1991 Nov; 46(11):1297-310. PubMed ID: 1811616
[TBL] [Abstract][Full Text] [Related]
31. Thrombin inhibitor design.
Sanderson PE; Naylor-Olsen AM
Curr Med Chem; 1998 Aug; 5(4):289-304. PubMed ID: 9668196
[TBL] [Abstract][Full Text] [Related]
32. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
Isaacs RC; Solinsky MG; Cutrona KJ; Newton CL; Naylor-Olsen AM; McMasters DR; Krueger JA; Lewis SD; Lucas BJ; Kuo LC; Yan Y; Lynch JJ; Lyle EA
Bioorg Med Chem Lett; 2008 Mar; 18(6):2062-6. PubMed ID: 18291642
[TBL] [Abstract][Full Text] [Related]
33. Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines.
Dosa S; Stirnberg M; Lülsdorff V; Häußler D; Maurer E; Gütschow M
Bioorg Med Chem; 2012 Nov; 20(21):6489-505. PubMed ID: 23026080
[TBL] [Abstract][Full Text] [Related]
34. Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Banner DW; Hadváry P
J Biol Chem; 1991 Oct; 266(30):20085-93. PubMed ID: 1939071
[TBL] [Abstract][Full Text] [Related]
35. Pharmacological characterization of a new structural variant of 4-amidinophenylalanine amide-type synthetic thrombin inhibitor.
Hauptmann J; Kaiser B; Paintz M; Markwardt F
Pharmazie; 1989 Apr; 44(4):282-4. PubMed ID: 2772004
[TBL] [Abstract][Full Text] [Related]
36. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
37. D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.
Lange UE; Baucke D; Hornberger W; Mack H; Seitz W; Höffken HW
Bioorg Med Chem Lett; 2003 Jun; 13(12):2029-33. PubMed ID: 12781189
[TBL] [Abstract][Full Text] [Related]
38. Novel plasma kallikrein inhibitors of the benzamidine type.
Stürzebecher J; Prasa D; Wikström P; Vieweg H
Braz J Med Biol Res; 1994 Aug; 27(8):1929-34. PubMed ID: 7749383
[TBL] [Abstract][Full Text] [Related]
39. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
Lu T; Markotan T; Coppo F; Tomczuk B; Crysler C; Eisennagel S; Spurlino J; Gremminger L; Soll RM; Giardino EC; Bone R
Bioorg Med Chem Lett; 2004 Jul; 14(14):3727-31. PubMed ID: 15203151
[TBL] [Abstract][Full Text] [Related]
40. Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.
Tucker TJ; Lumma WC; Mulichak AM; Chen Z; Naylor-Olsen AM; Lewis SD; Lucas R; Freidinger RM; Kuo LC
J Med Chem; 1997 Mar; 40(6):830-2. PubMed ID: 9083470
[No Abstract] [Full Text] [Related]
[Previous] [Next] [New Search]
