233 related articles for article (PubMed ID: 10220346)
21. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
Heredia VV; Cooper WC; Kruger RG; Jin Y; Penning TM
Biochemistry; 2004 May; 43(19):5832-41. PubMed ID: 15134457
[TBL] [Abstract][Full Text] [Related]
22. Effects of substitution of tryptophan 412 in the substrate activation pathway of yeast pyruvate decarboxylase.
Li H; Jordan F
Biochemistry; 1999 Aug; 38(31):10004-12. PubMed ID: 10433707
[TBL] [Abstract][Full Text] [Related]
23. The catalytic mechanism and structure of thymidylate synthase.
Carreras CW; Santi DV
Annu Rev Biochem; 1995; 64():721-62. PubMed ID: 7574499
[TBL] [Abstract][Full Text] [Related]
24. Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate.
Liu Y; Barrett JE; Schultz PG; Santi DV
Biochemistry; 1999 Jan; 38(2):848-52. PubMed ID: 9888826
[TBL] [Abstract][Full Text] [Related]
25. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
Matthews DA; Villafranca JE; Janson CA; Smith WW; Welsh K; Freer S
J Mol Biol; 1990 Aug; 214(4):937-48. PubMed ID: 2201779
[TBL] [Abstract][Full Text] [Related]
26. Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase.
Chanama M; Chitnumsub P; Yuthavong Y
Mol Biochem Parasitol; 2005 Jan; 139(1):83-90. PubMed ID: 15610822
[TBL] [Abstract][Full Text] [Related]
27. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
Sayre PH; Finer-Moore JS; Fritz TA; Biermann D; Gates SB; MacKellar WC; Patel VF; Stroud RM
J Mol Biol; 2001 Nov; 313(4):813-29. PubMed ID: 11697906
[TBL] [Abstract][Full Text] [Related]
28. Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase.
Digits JA; Hedstrom L
Biochemistry; 1999 Feb; 38(8):2295-306. PubMed ID: 10029522
[TBL] [Abstract][Full Text] [Related]
29. Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor.
Chen CH; Davis RA; Maley F
Biochemistry; 1996 Jul; 35(26):8786-93. PubMed ID: 8679643
[TBL] [Abstract][Full Text] [Related]
30. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Hyatt DC; Maley F; Montfort WR
Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668
[TBL] [Abstract][Full Text] [Related]
31. Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.
Landis DM; Heindel CC; Loeb LA
Cancer Res; 2001 Jan; 61(2):666-72. PubMed ID: 11212266
[TBL] [Abstract][Full Text] [Related]
32. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
Matsunaga I; Ueda A; Sumimoto T; Ichihara K; Ayata M; Ogura H
Arch Biochem Biophys; 2001 Oct; 394(1):45-53. PubMed ID: 11566026
[TBL] [Abstract][Full Text] [Related]
33. Modification of Escherichia coli thymidylate synthase at tyrosine-94 by 5-imidazolylpropynyl-2'-deoxyuridine 5'-monophosphate.
Saxl RL; Reston J; Nie Z; Kalman TI; Maley F
Biochemistry; 2003 Apr; 42(15):4544-51. PubMed ID: 12693951
[TBL] [Abstract][Full Text] [Related]
34. Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.
Lobo AP; Nair MG; Changchien L; Weichsel A; Montfort WR; Maley F
Biochemistry; 1998 Mar; 37(13):4535-42. PubMed ID: 9521774
[TBL] [Abstract][Full Text] [Related]
35. Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site.
Antikainen NM; Hergenrother PJ; Harris MM; Corbett W; Martin SF
Biochemistry; 2003 Feb; 42(6):1603-10. PubMed ID: 12578373
[TBL] [Abstract][Full Text] [Related]
36. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
Kaiyawet N; Rungrotmongkol T; Hannongbua S
J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
[TBL] [Abstract][Full Text] [Related]
37. Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
Hughey CT; Barbour KW; Berger FG; Berger SH
Mol Pharmacol; 1993 Aug; 44(2):316-23. PubMed ID: 8355668
[TBL] [Abstract][Full Text] [Related]
38. Temperature-induced conformational change at the catalytic site of Sulfolobus solfataricus alcohol dehydrogenase highlighted by Asn249Tyr substitution. A hydrogen/deuterium exchange, kinetic, and fluorescence quenching study.
Secundo F; Russo C; Giordano A; Carrea G; Rossi M; Raia CA
Biochemistry; 2005 Aug; 44(33):11040-8. PubMed ID: 16101287
[TBL] [Abstract][Full Text] [Related]
39. Catalytic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: site-directed mutagenesis and biochemical studies.
Li Y; Wu Y; Blaszczyk J; Ji X; Yan H
Biochemistry; 2003 Feb; 42(6):1581-8. PubMed ID: 12578371
[TBL] [Abstract][Full Text] [Related]
40. Functional identity of the active sites of crustacean and viral thymidylate synthases.
Arvizu-Flores AA; Aispuro-Hernandez E; Garcia-Orozco KD; Varela-Romero A; Valenzuela-Soto E; Velazquez-Contreras EF; Rojo-Domínguez A; Yepiz-Plascencia G; Maley F; Sotelo-Mundo RR
Comp Biochem Physiol C Toxicol Pharmacol; 2009 Sep; 150(3):406-13. PubMed ID: 19559812
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]