These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

269 related articles for article (PubMed ID: 10327206)

  • 1. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
    Murayama O; Tomita T; Nihonmatsu N; Murayama M; Sun X; Honda T; Iwatsubo T; Takashima A
    Neurosci Lett; 1999 Apr; 265(1):61-3. PubMed ID: 10327206
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.
    Ancolio K; Marambaud P; Dauch P; Checler F
    J Neurochem; 1997 Dec; 69(6):2494-9. PubMed ID: 9375682
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
    Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido TC; Maruyama K; Iwatsubo T
    J Biol Chem; 1998 Aug; 273(33):21153-60. PubMed ID: 9694871
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
    Tan Y; Hong J; Doan T; McConlogue L; Maltese WA
    Biochim Biophys Acta; 1998 Jul; 1407(1):69-78. PubMed ID: 9639678
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.
    Petanceska SS; Seeger M; Checler F; Gandy S
    J Neurochem; 2000 May; 74(5):1878-84. PubMed ID: 10800930
    [TBL] [Abstract][Full Text] [Related]  

  • 8. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
    Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
    Steiner H; Revesz T; Neumann M; Romig H; Grim MG; Pesold B; Kretzschmar HA; Hardy J; Holton JL; Baumeister R; Houlden H; Haass C
    J Biol Chem; 2001 Mar; 276(10):7233-9. PubMed ID: 11084029
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations.
    Tagami S; Okochi M; Yanagida K; Kodama T; Arai T; Kuwano R; Ikeuchi T; Takeda M
    Neurodegener Dis; 2014; 13(2-3):166-70. PubMed ID: 24192669
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Abeta42, presenilins, and Alzheimer's disease.
    Iwatsubo T
    Neurobiol Aging; 1998; 19(1 Suppl):S11-3. PubMed ID: 9562460
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
    Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
    Biochemistry; 1999 Oct; 38(41):13602-9. PubMed ID: 10521267
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation.
    Kakuda N; Takami M; Okochi M; Kasuga K; Ihara Y; Ikeuchi T
    Transl Psychiatry; 2021 Nov; 11(1):558. PubMed ID: 34728605
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
    Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird TD; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
    Nat Med; 1996 Aug; 2(8):864-70. PubMed ID: 8705854
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin.
    Piccini A; Fassio A; Pasqualetto E; Vitali A; Borghi R; Palmieri D; Nacmias B; Sorbi S; Sitia R; Tabaton M
    Neurobiol Dis; 2004 Mar; 15(2):380-6. PubMed ID: 15006708
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease.
    Zhan Y; Zheng H; Wang C; Rong Z; Xiao N; Ma Q; Zhang YW
    Neurobiol Aging; 2017 Feb; 50():168.e1-168.e4. PubMed ID: 27836335
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA; Perez-Tur J; Golde TE; Hardy J
    Biochem Biophys Res Commun; 2000 Oct; 277(1):261-3. PubMed ID: 11027672
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
    Saura CA; Tomita T; Soriano S; Takahashi M; Leem JY; Honda T; Koo EH; Iwatsubo T; Thinakaran G
    J Biol Chem; 2000 Jun; 275(22):17136-42. PubMed ID: 10748144
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
    Sudoh S; Kawamura Y; Sato S; Wang R; Saido TC; Oyama F; Sakaki Y; Komano H; Yanagisawa K
    J Neurochem; 1998 Oct; 71(4):1535-43. PubMed ID: 9751187
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.