BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

273 related articles for article (PubMed ID: 10359460)

  • 1. Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.
    Tugnait M; Hawes EM; McKay G; Eichelbaum M; Midha KK
    Chem Biol Interact; 1999 Apr; 118(2):171-89. PubMed ID: 10359460
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine.
    Eiermann B; Engel G; Johansson I; Zanger UM; Bertilsson L
    Br J Clin Pharmacol; 1997 Nov; 44(5):439-46. PubMed ID: 9384460
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.
    Murray M; Zhang WV; Edwards RJ
    Basic Clin Pharmacol Toxicol; 2018 Apr; 122(4):388-395. PubMed ID: 29155491
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.
    Zhang WV; D'Esposito F; Edwards RJ; Ramzan I; Murray M
    Drug Metab Dispos; 2008 Dec; 36(12):2547-55. PubMed ID: 18809730
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.
    Renwick AB; Surry D; Price RJ; Lake BG; Evans DC
    Xenobiotica; 2000 Oct; 30(10):955-69. PubMed ID: 11315104
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
    Zhang WV; Ramzan I; Murray M
    J Pharmacol Exp Ther; 2007 Aug; 322(2):770-7. PubMed ID: 17522342
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
    Nakajima M; Nakamura S; Tokudome S; Shimada N; Yamazaki H; Yokoi T
    Drug Metab Dispos; 1999 Dec; 27(12):1381-91. PubMed ID: 10570018
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.
    Rodrigues AD; Roberts EM; Mulford DJ; Yao Y; Ouellet D
    Drug Metab Dispos; 1997 May; 25(5):623-30. PubMed ID: 9152603
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.
    Venkatakrishnan K; von Moltke LL; Duan SX; Fleishaker JC; Shader RI; Greenblatt DJ
    J Pharm Pharmacol; 1998 Mar; 50(3):265-74. PubMed ID: 9600717
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.
    Gorski JC; Jones DR; Wrighton SA; Hall SD
    Biochem Pharmacol; 1994 Jul; 48(1):173-82. PubMed ID: 8043020
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine.
    Wang RW; Liu L; Cheng H
    Drug Metab Dispos; 1996 Jul; 24(7):786-91. PubMed ID: 8818577
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.
    Jang GR; Wrighton SA; Benet LZ
    Biochem Pharmacol; 1996 Sep; 52(5):753-61. PubMed ID: 8765473
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.
    Gallagher EP; Kunze KL; Stapleton PL; Eaton DL
    Toxicol Appl Pharmacol; 1996 Dec; 141(2):595-606. PubMed ID: 8975785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.
    Butler AM; Murray M
    J Pharmacol Exp Ther; 1997 Feb; 280(2):966-73. PubMed ID: 9023313
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.
    Pan LP; De Vriendt C; Belpaire FM
    Pharmacogenetics; 1998 Oct; 8(5):383-9. PubMed ID: 9825830
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.
    Gallagher EP; Wienkers LC; Stapleton PL; Kunze KL; Eaton DL
    Cancer Res; 1994 Jan; 54(1):101-8. PubMed ID: 8261428
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
    Heyn H; White RB; Stevens JC
    Drug Metab Dispos; 1996 Sep; 24(9):948-54. PubMed ID: 8886603
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations.
    Olesen OV; Linnet K
    J Clin Pharmacol; 2001 Aug; 41(8):823-32. PubMed ID: 11504269
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.
    Nielsen TL; Rasmussen BB; Flinois JP; Beaune P; Brosen K
    J Pharmacol Exp Ther; 1999 Apr; 289(1):31-7. PubMed ID: 10086984
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine.
    Fang J; Coutts RT; McKenna KF; Baker GB
    Naunyn Schmiedebergs Arch Pharmacol; 1998 Nov; 358(5):592-9. PubMed ID: 9840430
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.