BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 10369406)

  • 1. Quantity of partial agonist activity for antiglucocorticoids complexed with mutant glucocorticoid receptors is constant in two different transactivation assays but not predictable from steroid structure.
    Sarlis NJ; Bayly SF; Szapary D; Simons SS
    J Steroid Biochem Mol Biol; 1999 Feb; 68(3-4):89-102. PubMed ID: 10369406
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.
    Cho S; Kagan BL; Blackford JA; Szapary D; Simons SS
    Mol Endocrinol; 2005 Feb; 19(2):290-311. PubMed ID: 15539428
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes.
    Cho S; Blackford JA; Simons SS
    Biochemistry; 2005 Mar; 44(9):3547-61. PubMed ID: 15736964
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties.
    Giannoukos G; Szapary D; Smith CL; Meeker JE; Simons SS
    Mol Endocrinol; 2001 Feb; 15(2):255-70. PubMed ID: 11158332
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Immunocytochemical analysis of hormone mediated nuclear translocation of wild type and mutant glucocorticoid receptors.
    Jewell CM; Webster JC; Burnstein KL; Sar M; Bodwell JE; Cidlowski JA
    J Steroid Biochem Mol Biol; 1995 Nov; 55(2):135-46. PubMed ID: 7495692
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Opposing effects of corepressor and coactivators in determining the dose-response curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor-regulated gene expression.
    Szapary D; Huang Y; Simons SS
    Mol Endocrinol; 1999 Dec; 13(12):2108-21. PubMed ID: 10598585
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Induction properties of a transiently transfected glucocorticoid-responsive gene vary with glucocorticoid receptor concentration.
    Szapary D; Xu M; Simons SS
    J Biol Chem; 1996 Nov; 271(48):30576-82. PubMed ID: 8940029
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glucocorticoid versus antiglucocorticoid activity: can a single functional group modification of glucocorticoid steroids always convey antiglucocorticoid activity?
    Lamontagne N; Mercier L; Pons M; Thompson EB; Simons SS
    Endocrinology; 1984 Jun; 114(6):2252-63. PubMed ID: 6547091
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modulation of induction properties of glucocorticoid receptor-agonist and -antagonist complexes by coactivators involves binding to receptors but is independent of ability of coactivators to augment transactivation.
    He Y; Szapary D; Simons SS
    J Biol Chem; 2002 Dec; 277(51):49256-66. PubMed ID: 12376547
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid receptor.
    Yoshikawa N; Makino Y; Okamoto K; Morimoto C; Makino I; Tanaka H
    J Biol Chem; 2002 Feb; 277(7):5529-40. PubMed ID: 11741935
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CBP (CREB binding protein) integrates NF-kappaB (nuclear factor-kappaB) and glucocorticoid receptor physical interactions and antagonism.
    McKay LI; Cidlowski JA
    Mol Endocrinol; 2000 Aug; 14(8):1222-34. PubMed ID: 10935546
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity.
    Schaaf MJ; Cidlowski JA
    Mol Cell Biol; 2003 Mar; 23(6):1922-34. PubMed ID: 12612067
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors.
    Lee GS; Simons SS
    Biochemistry; 2011 Jan; 50(3):356-66. PubMed ID: 21142156
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Repression of p65 transcriptional activation by the glucocorticoid receptor in the absence of receptor-coactivator interactions.
    Wu J; Li Y; Dietz J; Lala DS
    Mol Endocrinol; 2004 Jan; 18(1):53-62. PubMed ID: 14551261
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells.
    Fryer CJ; Kinyamu HK; Rogatsky I; Garabedian MJ; Archer TK
    J Biol Chem; 2000 Jun; 275(23):17771-7. PubMed ID: 10748103
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain.
    Garside H; Stevens A; Farrow S; Normand C; Houle B; Berry A; Maschera B; Ray D
    J Biol Chem; 2004 Nov; 279(48):50050-9. PubMed ID: 15355994
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.
    Tao YG; Xu Y; Xu HE; Simons SS
    Biochemistry; 2008 Jul; 47(29):7648-62. PubMed ID: 18578507
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription.
    Chen S; Sarlis NJ; Simons SS
    J Biol Chem; 2000 Sep; 275(39):30106-17. PubMed ID: 10899170
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Steroid-induced conformational changes of rat glucocorticoid receptor cause altered trypsin cleavage of the putative helix 6 in the ligand binding domain.
    Xu M; Modarress KJ; Meeker JE; Simons SS
    Mol Cell Endocrinol; 1999 Sep; 155(1-2):85-100. PubMed ID: 10580842
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional analysis of R651 mutations in the putative helix 6 of rat glucocorticoid receptors.
    Huang Y; Simons SS
    Mol Cell Endocrinol; 1999 Dec; 158(1-2):117-30. PubMed ID: 10630412
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.