These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 10375007)

  • 1. Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.
    Lewis DF; Lake BG; Dickins M; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Xenobiotica; 1999 Apr; 29(4):361-93. PubMed ID: 10375007
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular modelling of CYP2B6 based on homology with the CYP2C5 crystal structure: analysis of enzyme-substrate interactions.
    Lewis DF; Lake BG; Dickins M; Goldfarb PS
    Drug Metabol Drug Interact; 2002; 19(2):115-35. PubMed ID: 12751910
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure.
    Lewis DF
    Xenobiotica; 2002 Apr; 32(4):305-23. PubMed ID: 12028664
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes.
    Chen C; Liu J; Halpert JR; Wilderman PR
    Biochemistry; 2018 Feb; 57(5):817-826. PubMed ID: 29215266
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102.
    Lewis DF; Lake BG
    Xenobiotica; 1999 Aug; 29(8):763-81. PubMed ID: 10553718
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners.
    Lewis DF; Lake BG
    Xenobiotica; 1997 May; 27(5):443-78. PubMed ID: 9179987
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform.
    Lewis DF; Bird MG; Dickins M; Lake BG; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Xenobiotica; 2000 Jan; 30(1):1-25. PubMed ID: 10659948
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences.
    Lewis DF; Ito Y; Lake BG
    J Enzyme Inhib Med Chem; 2010 Oct; 25(5):679-84. PubMed ID: 20100069
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles.
    Spatzenegger M; Wang Q; He YQ; Wester MR; Johnson EF; Halpert JR
    Mol Pharmacol; 2001 Mar; 59(3):475-84. PubMed ID: 11179442
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.
    Lewis DF; Lake BG; George SG; Dickins M; Eddershaw PJ; Tarbit MH; Beresford AP; Goldfarb PS; Guengerich FP
    Toxicology; 1999 Nov; 139(1-2):53-79. PubMed ID: 10614688
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
    Lewis DF
    Arch Biochem Biophys; 2003 Jan; 409(1):32-44. PubMed ID: 12464242
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.
    Lewis DF
    Exp Toxicol Pathol; 1999 Jul; 51(4-5):369-74. PubMed ID: 10445400
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.
    Lewis DF; Dickins M; Weaver RJ; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1998 Mar; 28(3):235-68. PubMed ID: 9574814
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Investigating human P450s involved in drug metabolism via homology with high-resolution P450 crystal structures of the CYP2C subfamily.
    Lewis DF; Ito Y; Goldfarb PS
    Curr Drug Metab; 2006 Aug; 7(6):589-98. PubMed ID: 16918314
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.
    Wang H; Dick R; Yin H; Licad-Coles E; Kroetz DL; Szklarz G; Harlow G; Halpert JR; Correia MA
    Biochemistry; 1998 Sep; 37(36):12536-45. PubMed ID: 9730826
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling.
    Wang Q; Halpert JR
    Drug Metab Dispos; 2002 Jan; 30(1):86-95. PubMed ID: 11744616
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM; Mills DE; Rajnarayanan RV; Alworth WL; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular modelling of steroidogenic cytochromes P450 from families CYP11, CYP17, CYP19 and CYP21 based on the CYP102 crystal structure.
    Lewis DF; Lee-Robichaud P
    J Steroid Biochem Mol Biol; 1998 Aug; 66(4):217-33. PubMed ID: 9744519
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity.
    Lewis DF; Dickins M; Lake BG; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Toxicology; 1999 Mar; 133(1):1-33. PubMed ID: 10413191
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.
    Lewis DF; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1997 Apr; 27(4):319-39. PubMed ID: 9149373
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.