These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 10377217)

  • 1. Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.
    Costi PM; Rinaldi M; Tondi D; Pecorari P; Barlocco D; Ghelli S; Stroud RM; Santi DV; Stout TJ; Musiu C; Marangiu EM; Pani A; Congiu D; Loi GA; La Colla P
    J Med Chem; 1999 Jun; 42(12):2112-24. PubMed ID: 10377217
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity.
    Ghelli S; Rinaldi M; Barlocco D; Gelain A; Pecorari P; Tondi D; Rastelli G; Costi MP
    Bioorg Med Chem; 2003 Mar; 11(6):951-63. PubMed ID: 12614880
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.
    Mangani S; Cancian L; Leone R; Pozzi C; Lazzari S; Luciani R; Ferrari S; Costi MP
    J Med Chem; 2011 Aug; 54(15):5454-67. PubMed ID: 21696158
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antibacterial agent discovery using thymidylate synthase biolibrary screening.
    Costi MP; Gelain A; Barlocco D; Ghelli S; Soragni F; Reniero F; Rossi T; Ruberto A; Guillou C; Cavazzuti A; Casolari C; Ferrari S
    J Med Chem; 2006 Oct; 49(20):5958-68. PubMed ID: 17004711
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase.
    Gangjee A; Mavandadi F; Kisliuk RL; Queener SF
    J Med Chem; 1999 Jun; 42(12):2272-9. PubMed ID: 10377234
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
    J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
    Fritz TA; Tondi D; Finer-Moore JS; Costi MP; Stroud RM
    Chem Biol; 2001 Oct; 8(10):981-95. PubMed ID: 11590022
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-based design of inhibitors specific for bacterial thymidylate synthase.
    Stout TJ; Tondi D; Rinaldi M; Barlocco D; Pecorari P; Santi DV; Kuntz ID; Stroud RM; Shoichet BK; Costi MP
    Biochemistry; 1999 Feb; 38(5):1607-17. PubMed ID: 9931028
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.
    Tondi D; Venturelli A; Ferrari S; Ghelli S; Costi MP
    J Med Chem; 2005 Feb; 48(4):913-6. PubMed ID: 15715461
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
    Anderson AC; Perry KM; Freymann DM; Stroud RM
    J Mol Biol; 2000 Mar; 297(3):645-57. PubMed ID: 10731418
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.
    Tondi D; Slomczynska U; Costi MP; Watterson DM; Ghelli S; Shoichet BK
    Chem Biol; 1999 May; 6(5):319-31. PubMed ID: 10322126
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.
    Calò S; Tondi D; Ferrari S; Venturelli A; Ghelli S; Costi MP
    Chembiochem; 2008 Mar; 9(5):779-90. PubMed ID: 18344216
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based studies on species-specific inhibition of thymidylate synthase.
    Costi MP; Tondi D; Rinaldi M; Barlocco D; Pecorari P; Soragni F; Venturelli A; Stroud RM
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):206-14. PubMed ID: 12084462
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
    Du QR; Li DD; Pi YZ; Li JR; Sun J; Fang F; Zhong WQ; Gong HB; Zhu HL
    Bioorg Med Chem; 2013 Apr; 21(8):2286-2297. PubMed ID: 23490159
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
    Gangjee A; Mavandadi F; Kisliuk RL; McGuire JJ; Queener SF
    J Med Chem; 1996 Nov; 39(23):4563-8. PubMed ID: 8917644
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
    Lu GQ; Li XY; Mohamed O K; Wang D; Meng FH
    Eur J Med Chem; 2019 Jun; 171():282-296. PubMed ID: 30927565
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.
    Ferrari S; Calò S; Leone R; Luciani R; Costantino L; Sammak S; Di Pisa F; Pozzi C; Mangani S; Costi MP
    J Med Chem; 2013 Nov; 56(22):9356-60. PubMed ID: 24147825
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
    Finer-Moore JS; Anderson AC; O'Neil RH; Costi MP; Ferrari S; Krucinski J; Stroud RM
    Acta Crystallogr D Biol Crystallogr; 2005 Oct; 61(Pt 10):1320-34. PubMed ID: 16204883
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thymidylate synthase inhibition: a structure-based rationale for drug design.
    Costi MP
    Med Res Rev; 1998 Jan; 18(1):21-42. PubMed ID: 9436180
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
    J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.