BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 10383565)

  • 1. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations.
    Von Moltke LL; Greenblatt DJ; Granda BW; Duan SX; Grassi JM; Venkatakrishnan K; Harmatz JS; Shader RI
    Br J Clin Pharmacol; 1999 Jul; 48(1):89-97. PubMed ID: 10383565
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions.
    Warrington JS; Shader RI; von Moltke LL; Greenblatt DJ
    Drug Metab Dispos; 2000 Apr; 28(4):392-7. PubMed ID: 10725306
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
    Hesse LM; Venkatakrishnan K; von Moltke LL; Shader RI; Greenblatt DJ
    Drug Metab Dispos; 2001 Feb; 29(2):133-40. PubMed ID: 11159802
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Oxidative metabolism of zolpidem by human liver cytochrome P450S.
    Pichard L; Gillet G; Bonfils C; Domergue J; Thénot JP; Maurel P
    Drug Metab Dispos; 1995 Nov; 23(11):1253-62. PubMed ID: 8591727
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4.
    Venkatakrishnan K; Greenblatt DJ; von Moltke LL; Schmider J; Harmatz JS; Shader RI
    J Clin Pharmacol; 1998 Feb; 38(2):112-21. PubMed ID: 9549641
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects.
    von Moltke LL; Greenblatt DJ; Grassi JM; Granda BW; Fogelman SM; Harmatz JS; Kramer SJ; Fabre LF; Shader RI
    Psychopharmacology (Berl); 1998 Dec; 140(3):293-9. PubMed ID: 9877009
    [TBL] [Abstract][Full Text] [Related]  

  • 7. O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants.
    Fogelman SM; Schmider J; Venkatakrishnan K; von Moltke LL; Harmatz JS; Shader RI; Greenblatt DJ
    Neuropsychopharmacology; 1999 May; 20(5):480-90. PubMed ID: 10192828
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine I-carboxamide).
    Bournique B; Lambert N; Boukaiba R; Martinet M
    Br J Clin Pharmacol; 2001 Jul; 52(1):53-63. PubMed ID: 11453890
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.
    von Moltke LL; Greenblatt DJ; Harmatz JS; Duan SX; Harrel LM; Cotreau-Bibbo MM; Pritchard GA; Wright CE; Shader RI
    J Pharmacol Exp Ther; 1996 Feb; 276(2):370-9. PubMed ID: 8632299
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.
    Venkatakrishnan K; von Moltke LL; Greenblatt DJ
    J Pharmacol Exp Ther; 2001 Apr; 297(1):326-37. PubMed ID: 11259560
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.
    von Moltke LL; Greenblatt DJ; Grassi JM; Granda BW; Venkatakrishnan K; Duan SX; Fogelman SM; Harmatz JS; Shader RI
    Biol Psychiatry; 1999 Sep; 46(6):839-49. PubMed ID: 10494454
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
    Obach RS
    Drug Metab Dispos; 2000 Sep; 28(9):1069-76. PubMed ID: 10950851
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biotransformation of fluticasone: in vitro characterization.
    Pearce RE; Leeder JS; Kearns GL
    Drug Metab Dispos; 2006 Jun; 34(6):1035-40. PubMed ID: 16565171
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.
    von Moltke LL; Greenblatt DJ; Granda BW; Grassi JM; Schmider J; Harmatz JS; Shader RI
    Psychopharmacology (Berl); 1999 Jul; 145(1):113-22. PubMed ID: 10445380
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.
    Baldwin SJ; Clarke SE; Chenery RJ
    Br J Clin Pharmacol; 1999 Sep; 48(3):424-32. PubMed ID: 10510156
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
    Jeurissen SM; Bogaards JJ; Boersma MG; ter Horst JP; Awad HM; Fiamegos YC; van Beek TA; Alink GM; Sudhölter EJ; Cnubben NH; Rietjens IM
    Chem Res Toxicol; 2006 Jan; 19(1):111-6. PubMed ID: 16411663
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.
    Uttamsingh V; Lu C; Miwa G; Gan LS
    Drug Metab Dispos; 2005 Nov; 33(11):1723-8. PubMed ID: 16103134
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450.
    Rehmel JL; Eckstein JA; Farid NA; Heim JB; Kasper SC; Kurihara A; Wrighton SA; Ring BJ
    Drug Metab Dispos; 2006 Apr; 34(4):600-7. PubMed ID: 16415119
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.
    Haaz MC; Rivory L; Riché C; Vernillet L; Robert J
    Cancer Res; 1998 Feb; 58(3):468-72. PubMed ID: 9458091
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine.
    Olesen OV; Linnet K
    Br J Clin Pharmacol; 2000 Dec; 50(6):563-71. PubMed ID: 11136295
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.