BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 10386952)

  • 1. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC; Ghadge GD; Miller RJ; Roos RP
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F; Czech C; Esclaire F; Elyaman W; Yardin C; Baclet MC; Touchet N; Tremp G; Pradier L; Hugon J
    J Neurosci Res; 2002 Aug; 69(4):530-9. PubMed ID: 12210846
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
    Lévesque L; Annaert W; Craessaerts K; Mathews PM; Seeger M; Nixon RA; Van Leuven F; Gandy S; Westaway D; St George-Hyslop P; De Strooper B; Fraser PE
    Mol Med; 1999 Aug; 5(8):542-54. PubMed ID: 10501657
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH; Hof PR; Chen X; Gluck K; Austin G; Younkin SG; Younkin LH; DeGasperi R; Gama Sosa MA; Robakis NK; Haroutunian V; Elder GA
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
    Tanii H; Ankarcrona M; Flood F; Nilsberth C; Mehta ND; Perez-Tur J; Winblad B; Benedikz E; Cowburn RF
    Neuroscience; 2000; 95(2):593-601. PubMed ID: 10658639
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
    Kovacs DM; Mancini R; Henderson J; Na SJ; Schmidt SD; Kim TW; Tanzi RE
    J Neurochem; 1999 Dec; 73(6):2278-85. PubMed ID: 10582585
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.
    Xie Z; Romano DM; Tanzi RE
    J Mol Neurosci; 2005; 25(1):67-77. PubMed ID: 15781968
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
    Lee MK; Borchelt DR; Kim G; Thinakaran G; Slunt HH; Ratovitski T; Martin LJ; Kittur A; Gandy S; Levey AI; Jenkins N; Copeland N; Price DL; Sisodia SS
    Nat Med; 1997 Jul; 3(7):756-60. PubMed ID: 9212102
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
    Weihl CC; Ghadge GD; Kennedy SG; Hay N; Miller RJ; Roos RP
    J Neurosci; 1999 Jul; 19(13):5360-9. PubMed ID: 10377346
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL; Culmsee C; Haughey N; Klapper W; Mattson MP
    Neurobiol Dis; 2002 Oct; 11(1):2-19. PubMed ID: 12460542
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Implications of presenilin 1 mutations in Alzheimer's disease.
    Komano H; Sudoh S; Kawamura Y; Wang R; Yanagisawa K
    Mech Ageing Dev; 1999 Mar; 107(3):281-98. PubMed ID: 10360683
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.
    Gamliel A; Teicher C; Hartmann T; Beyreuther K; Stein R
    Neuroscience; 2003; 117(1):19-28. PubMed ID: 12605888
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
    Tekirian TL; Merriam DE; Marshansky V; Miller J; Crowley AC; Chan H; Ausiello D; Brown D; Buxbaum JD; Xia W; Wasco W
    Brain Res Mol Brain Res; 2001 Nov; 96(1-2):14-20. PubMed ID: 11731004
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
    Popescu BO; Cedazo-Minguez A; Popescu LM; Winblad B; Cowburn RF; Ankarcrona M
    J Neurosci Res; 2001 Oct; 66(1):122-34. PubMed ID: 11599009
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.
    Wisniewski T; Dowjat WK; Buxbaum JD; Khorkova O; Efthimiopoulos S; Kulczycki J; Lojkowska W; Wegiel J; Wisniewski HM; Frangione B
    Neuroreport; 1998 Jan; 9(2):217-21. PubMed ID: 9507958
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
    Tokuhiro S; Tomita T; Iwata H; Kosaka T; Saido TC; Maruyama K; Iwatsubo T
    Biochem Biophys Res Commun; 1998 Mar; 244(3):751-5. PubMed ID: 9535737
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
    Kim TW; Pettingell WH; Jung YK; Kovacs DM; Tanzi RE
    Science; 1997 Jul; 277(5324):373-6. PubMed ID: 9219695
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
    Borchelt DR; Thinakaran G; Eckman CB; Lee MK; Davenport F; Ratovitsky T; Prada CM; Kim G; Seekins S; Yager D; Slunt HH; Wang R; Seeger M; Levey AI; Gandy SE; Copeland NG; Jenkins NA; Price DL; Younkin SG; Sisodia SS
    Neuron; 1996 Nov; 17(5):1005-13. PubMed ID: 8938131
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.