189 related articles for article (PubMed ID: 10390604)
1. Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
Minakawa N; Matsuda A
Curr Med Chem; 1999 Jul; 6(7):615-28. PubMed ID: 10390604
[TBL] [Abstract][Full Text] [Related]
2. Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
Balzarini J; Karlsson A; Wang L; Bohman C; Horská K; Votruba I; Fridland A; Van Aerschot A; Herdewijn P; De Clercq E
J Biol Chem; 1993 Nov; 268(33):24591-8. PubMed ID: 7901217
[TBL] [Abstract][Full Text] [Related]
3. Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.
Balzarini J; Stet L; Matsuda A; Wiebe L; Knauss E; De Clercq E
Adv Exp Med Biol; 1998; 431():723-8. PubMed ID: 9598159
[TBL] [Abstract][Full Text] [Related]
4. Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate.
Wang W; Papov VV; Minakawa N; Matsuda A; Biemann K; Hedstrom L
Biochemistry; 1996 Jan; 35(1):95-101. PubMed ID: 8555204
[TBL] [Abstract][Full Text] [Related]
5. Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.
Franchetti P; Grifantini M
Curr Med Chem; 1999 Jul; 6(7):599-614. PubMed ID: 10390603
[TBL] [Abstract][Full Text] [Related]
6. 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes.
Balzarini J; Lee CK; Schols D; De Clercq E
Biochem Biophys Res Commun; 1991 Jul; 178(2):563-9. PubMed ID: 1650194
[TBL] [Abstract][Full Text] [Related]
7. Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus.
Ölschläger S; Neyts J; Günther S
Antiviral Res; 2011 Aug; 91(2):89-93. PubMed ID: 21616094
[TBL] [Abstract][Full Text] [Related]
8. Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
Minakawa N; Takeda T; Sasaki T; Matsuda A; Ueda T
J Med Chem; 1991 Feb; 34(2):778-86. PubMed ID: 1995901
[TBL] [Abstract][Full Text] [Related]
9. Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
Franchetti P; Cappellacci L; Grifantini M; Barzi A; Nocentini G; Yang H; O'Connor A; Jayaram HN; Carrell C; Goldstein BM
J Med Chem; 1995 Sep; 38(19):3829-37. PubMed ID: 7562914
[TBL] [Abstract][Full Text] [Related]
10. Antiviral efficacy of EICAR against canine distemper virus (CDV) in vitro.
Dal Pozzo F; Galligioni V; Vaccari F; Gallina L; Battilani M; Scagliarini A
Res Vet Sci; 2010 Apr; 88(2):339-44. PubMed ID: 19781726
[TBL] [Abstract][Full Text] [Related]
11. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Jayaram HN; Cooney DA; Grusch M; Krupitza G
Curr Med Chem; 1999 Jul; 6(7):561-74. PubMed ID: 10390601
[TBL] [Abstract][Full Text] [Related]
12. The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.
Leyssen P; Balzarini J; De Clercq E; Neyts J
J Virol; 2005 Feb; 79(3):1943-7. PubMed ID: 15650220
[TBL] [Abstract][Full Text] [Related]
13. Inhibitors of infectious pancreatic necrosis virus (IPNV) replication.
Jashés M; González M; López-Lastra M; De Clercq E; Sandino A
Antiviral Res; 1996 Mar; 29(2-3):309-12. PubMed ID: 8739609
[TBL] [Abstract][Full Text] [Related]
14. Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds.
De Clercq E; Cools M; Balzarini J; Snoeck R; Andrei G; Hosoya M; Shigeta S; Ueda T; Minakawa N; Matsuda A
Antimicrob Agents Chemother; 1991 Apr; 35(4):679-84. PubMed ID: 2069373
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
McMillan FM; Cahoon M; White A; Hedstrom L; Petsko GA; Ringe D
Biochemistry; 2000 Apr; 39(15):4533-42. PubMed ID: 10758003
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
Franchetti P; Cappellacci L; Sheikha GA; Jayaram HN; Gurudutt VV; Sint T; Schneider BP; Jones WD; Goldstein BM; Perra G; De Montis A; Loi AG; La Colla P; Grifantini M
J Med Chem; 1997 May; 40(11):1731-7. PubMed ID: 9171883
[TBL] [Abstract][Full Text] [Related]
17. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.
Gharehbaghi K; Sreenath A; Hao Z; Paull KD; Szekeres T; Cooney DA; Krohn K; Jayaram HN
Biochem Pharmacol; 1994 Oct; 48(7):1413-9. PubMed ID: 7945441
[TBL] [Abstract][Full Text] [Related]
18. Antiviral activities of ribavirin, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide, and 6'-(R)-6'-C-methylneplanocin A against several ortho- and paramyxoviruses.
Shigeta S; Mori S; Baba M; Ito M; Honzumi K; Nakamura K; Oshitani H; Numazaki Y; Matsuda A; Obara T
Antimicrob Agents Chemother; 1992 Feb; 36(2):435-9. PubMed ID: 1605607
[TBL] [Abstract][Full Text] [Related]
19. Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Pankiewicz KW; Patterson SE; Black PL; Jayaram HN; Risal D; Goldstein BM; Stuyver LJ; Schinazi RF
Curr Med Chem; 2004 Apr; 11(7):887-900. PubMed ID: 15083807
[TBL] [Abstract][Full Text] [Related]
20. The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
Pankiewicz KW; Watanabe KA; Lesiak-Watanabe K; Goldstein BM; Jayaram HN
Curr Med Chem; 2002 Apr; 9(7):733-41. PubMed ID: 11966436
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
