BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

138 related articles for article (PubMed ID: 10406217)

  • 1. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.
    Bak A; Siahaan TJ; Gudmundsson OS; Gangwar S; Friis GJ; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):393-402. PubMed ID: 10406217
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.
    Wang B; Nimkar K; Wang W; Zhang H; Shan D; Gudmundsson O; Gangwar S; Siahaan T; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):370-82. PubMed ID: 10406215
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS; Nimkar K; Gangwar S; Siahaan T; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):16-23. PubMed ID: 9950273
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM; Borchardt RT
    J Pharm Sci; 2005 Oct; 94(10):2198-206. PubMed ID: 16136552
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.
    Gudmundsson OS; Vander Velde DG; Jois SD; Bak A; Siahaan TJ; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):403-13. PubMed ID: 10406218
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A; Gudmundsson OS; Friis GJ; Siahaan TJ; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.
    Gudmundsson OS; Pauletti GM; Wang W; Shan D; Zhang H; Wang B; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):7-15. PubMed ID: 9950272
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides.
    Liederer BM; Fuchs T; Vander Velde D; Siahaan TJ; Borchardt RT
    J Med Chem; 2006 Feb; 49(4):1261-70. PubMed ID: 16480263
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion.
    Ouyang H; Vander Velde DG; Borchardt RT; Siahaan TJ
    J Pept Res; 2002 Apr; 59(4):183-95. PubMed ID: 11972752
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimizing oral absorption of peptides using prodrug strategies.
    Borchardt RT
    J Control Release; 1999 Nov; 62(1-2):231-8. PubMed ID: 10518655
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.
    Gudmundsson OS; Jois SD; Vander Velde DG; Siahaan TJ; Wang B; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):383-92. PubMed ID: 10406216
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Syntheses of cyclic prodrugs of RGD peptidomimetics with various macrocyclic ring sizes: evaluation of physicochemical, transport and antithrombic properties.
    He HT; Xu CR; Song X; Siahaan TJ
    J Pept Res; 2003 Jun; 61(6):331-42. PubMed ID: 12753380
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
    Chen W; Yang JZ; Andersen R; Nielsen LH; Borchardt RT
    J Pharmacol Exp Ther; 2002 Nov; 303(2):849-57. PubMed ID: 12388672
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties.
    Zych LA; Yang W; Liao Y; Griffin KR; Wang B
    Bioorg Chem; 2004 Apr; 32(2):109-23. PubMed ID: 14990309
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
    Yang JZ; Chen W; Borchardt RT
    J Pharmacol Exp Ther; 2002 Nov; 303(2):840-8. PubMed ID: 12388671
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide.
    Pauletti GM; Gangwar S; Okumu FW; Siahaan TJ; Stella VJ; Borchardt RT
    Pharm Res; 1996 Nov; 13(11):1615-23. PubMed ID: 8956324
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of novel coumarin-based esterase-sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability.
    Wang B; Wang W; Camenisch GP; Elmo J; Zhang H; Borchardt RT
    Chem Pharm Bull (Tokyo); 1999 Jan; 47(1):90-5. PubMed ID: 9987829
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa.
    Nofsinger R; Borchardt RT
    J Pharm Sci; 2012 Sep; 101(9):3500-10. PubMed ID: 22337204
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
    Liederer BM; Phan KT; Ouyang H; Borchardt RT
    J Pharm Sci; 2005 Dec; 94(12):2676-87. PubMed ID: 16258984
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).
    Ouyang H; Andersen TE; Chen W; Nofsinger R; Steffansen B; Borchardt RT
    J Pharm Sci; 2009 Jun; 98(6):2227-36. PubMed ID: 18855917
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.