BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 10409393)

  • 1. Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening.
    Onderwater RC; Venhorst J; Commandeur JN; Vermeulen NP
    Chem Res Toxicol; 1999 Jul; 12(7):555-9. PubMed ID: 10409393
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.
    Venhorst J; Onderwater RC; Meerman JH; Commandeur JN; Vermeulen NP
    Drug Metab Dispos; 2000 Dec; 28(12):1524-32. PubMed ID: 11095593
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Coumarin substrates for cytochrome P450 2D6 fluorescence assays.
    Nakamura K; Hanna IH; Cai H; Nishimura Y; Williams KM; Guengerich FP
    Anal Biochem; 2001 May; 292(2):280-6. PubMed ID: 11355862
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS; Kupfer D
    Cancer Res; 1997 Aug; 57(16):3402-6. PubMed ID: 9270005
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H; Guo Z; Persmark M; Mimura M; Inoue K; Guengerich FP; Shimada T
    Mol Pharmacol; 1994 Sep; 46(3):568-77. PubMed ID: 7935340
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
    Keizers PH; Lussenburg BM; de Graaf C; Mentink LM; Vermeulen NP; Commandeur JN
    Biochem Pharmacol; 2004 Dec; 68(11):2263-71. PubMed ID: 15498516
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points.
    Keizers PH; Van Dijk BR; De Graaf C; Van Vugt-Lussenburg BM; Vermeulen NP; Commandeur JN
    Xenobiotica; 2006 Sep; 36(9):763-71. PubMed ID: 16971342
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
    Teiber JF; Hollenberg PF
    Carcinogenesis; 2000 Aug; 21(8):1559-66. PubMed ID: 10910959
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.
    Dong H; Haining RL; Thummel KE; Rettie AE; Nelson SD
    Drug Metab Dispos; 2000 Dec; 28(12):1397-400. PubMed ID: 11095574
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin.
    Venhorst J; Onderwater RC; Meerman JH; Vermeulen NP; Commandeur JN
    Eur J Pharm Sci; 2000 Dec; 12(2):151-8. PubMed ID: 11102743
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
    Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.
    Hickman D; Wang JP; Wang Y; Unadkat JD
    Drug Metab Dispos; 1998 Mar; 26(3):207-15. PubMed ID: 9492382
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of cytochrome P450 enzymes involved in the metabolism of the designer drugs N-(1-phenylcyclohexyl)-3-ethoxypropanamine and N-(1-phenylcyclohexyl)-3-methoxypropanamine.
    Sauer C; Peters FT; Schwaninger AE; Meyer MR; Maurer HH
    Chem Res Toxicol; 2008 Oct; 21(10):1949-55. PubMed ID: 18778087
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
    Yang TJ; Krausz KW; Sai Y; Gonzalez FJ; Gelboin HV
    Drug Metab Dispos; 1999 Jan; 27(1):102-9. PubMed ID: 9884317
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
    Shou M; Krausz KW; Gonzalez FJ; Gelboin HV
    Arch Biochem Biophys; 1996 Apr; 328(1):201-7. PubMed ID: 8638931
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
    Avent KM; DeVoss JJ; Gillam EM
    Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
    Spracklin DK; Hankins DC; Fisher JM; Thummel KE; Kharasch ED
    J Pharmacol Exp Ther; 1997 Apr; 281(1):400-11. PubMed ID: 9103523
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.
    Raghavan N; Zhang D; Zhu M; Zeng J; Christopher L
    Drug Metab Dispos; 2005 Feb; 33(2):203-8. PubMed ID: 15507542
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of human cytochrome P450 2D6 as major enzyme involved in the O-demethylation of the designer drug p-methoxymethamphetamine.
    Staack RF; Theobald DS; Paul LD; Springer D; Kraemer T; Maurer HH
    Drug Metab Dispos; 2004 Apr; 32(4):379-81. PubMed ID: 15039289
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.