BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

395 related articles for article (PubMed ID: 10447203)

  • 1. Molecular dynamics simulations of P450 BM3--examination of substrate-induced conformational change.
    Chang YT; Loew GH
    J Biomol Struct Dyn; 1999 Jun; 16(6):1189-203. PubMed ID: 10447203
    [TBL] [Abstract][Full Text] [Related]  

  • 2. How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms.
    Lüdemann SK; Lounnas V; Wade RC
    J Mol Biol; 2000 Nov; 303(5):797-811. PubMed ID: 11061976
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.
    Gustafsson MC; Roitel O; Marshall KR; Noble MA; Chapman SK; Pessegueiro A; Fulco AJ; Cheesman MR; von Wachenfeldt C; Munro AW
    Biochemistry; 2004 May; 43(18):5474-87. PubMed ID: 15122913
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid.
    Li H; Poulos TL
    Nat Struct Biol; 1997 Feb; 4(2):140-6. PubMed ID: 9033595
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
    Haines DC; Chen B; Tomchick DR; Bondlela M; Hegde A; Machius M; Peterson JA
    Biochemistry; 2008 Mar; 47(12):3662-70. PubMed ID: 18298086
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational dynamics in cytochrome P450-substrate interactions.
    Li H; Poulos TL
    Biochimie; 1996; 78(8-9):695-9. PubMed ID: 9010597
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.
    Huang WC; Westlake AC; Maréchal JD; Joyce MG; Moody PC; Roberts GC
    J Mol Biol; 2007 Oct; 373(3):633-51. PubMed ID: 17868686
    [TBL] [Abstract][Full Text] [Related]  

  • 8. How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways.
    Lüdemann SK; Lounnas V; Wade RC
    J Mol Biol; 2000 Nov; 303(5):813-30. PubMed ID: 11061977
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant.
    Whitehouse CJ; Yang W; Yorke JA; Tufton HG; Ogilvie LC; Bell SG; Zhou W; Bartlam M; Rao Z; Wong LL
    Dalton Trans; 2011 Oct; 40(40):10383-96. PubMed ID: 21603690
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3.
    Noble MA; Quaroni L; Chumanov GD; Turner KL; Chapman SK; Hanzlik RP; Munro AW
    Biochemistry; 1998 Nov; 37(45):15799-807. PubMed ID: 9843385
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Electron transfer in flavocytochrome P450 BM3: kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase.
    Roitel O; Scrutton NS; Munro AW
    Biochemistry; 2003 Sep; 42(36):10809-21. PubMed ID: 12962506
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.
    Joyce MG; Girvan HM; Munro AW; Leys D
    J Biol Chem; 2004 May; 279(22):23287-93. PubMed ID: 15020590
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.
    Girvan HM; Seward HE; Toogood HS; Cheesman MR; Leys D; Munro AW
    J Biol Chem; 2007 Jan; 282(1):564-72. PubMed ID: 17077084
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
    Modi S; Paine MJ; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
    Biochemistry; 1996 Apr; 35(14):4540-50. PubMed ID: 8605204
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interactions of substrates at the surface of P450s can greatly enhance substrate potency.
    Hegde A; Haines DC; Bondlela M; Chen B; Schaffer N; Tomchick DR; Machius M; Nguyen H; Chowdhary PK; Stewart L; Lopez C; Peterson JA
    Biochemistry; 2007 Dec; 46(49):14010-7. PubMed ID: 18004886
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties.
    Fasan R; Chen MM; Crook NC; Arnold FH
    Angew Chem Int Ed Engl; 2007; 46(44):8414-8. PubMed ID: 17886313
    [No Abstract]   [Full Text] [Related]  

  • 17. Oxygen activation and electron transfer in flavocytochrome P450 BM3.
    Ost TW; Clark J; Mowat CG; Miles CS; Walkinshaw MD; Reid GA; Chapman SK; Daff S
    J Am Chem Soc; 2003 Dec; 125(49):15010-20. PubMed ID: 14653735
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.
    Noble MA; Girvan HM; Smith SJ; Smith WE; Murataliev M; Guzov VM; Feyereisen R; Munro AW
    Drug Metab Rev; 2007; 39(2-3):599-617. PubMed ID: 17786641
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Roles of key active-site residues in flavocytochrome P450 BM3.
    Noble MA; Miles CS; Chapman SK; Lysek DA; MacKay AC; Reid GA; Hanzlik RP; Munro AW
    Biochem J; 1999 Apr; 339 ( Pt 2)(Pt 2):371-9. PubMed ID: 10191269
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Are branched chain fatty acids the natural substrates for P450(BM3)?
    Cryle MJ; Espinoza RD; Smith SJ; Matovic NJ; De Voss JJ
    Chem Commun (Camb); 2006 Jun; (22):2353-5. PubMed ID: 16733577
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.