183 related articles for article (PubMed ID: 10450927)
1. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1999 Jul; 16(7):1035-40. PubMed ID: 10450927
[TBL] [Abstract][Full Text] [Related]
2. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
van Gelder J; Deferme S; Naesens L; De Clercq E; van den Mooter G; Kinget R; Augustijns P
Drug Metab Dispos; 2002 Aug; 30(8):924-30. PubMed ID: 12124311
[TBL] [Abstract][Full Text] [Related]
3. Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Shaw JP; Sueoko CM; Oliyai R; Lee WA; Arimilli MN; Kim CU; Cundy KC
Pharm Res; 1997 Dec; 14(12):1824-9. PubMed ID: 9453075
[TBL] [Abstract][Full Text] [Related]
4. Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
Naesens L; Bischofberger N; Augustijns P; Annaert P; Van den Mooter G; Arimilli MN; Kim CU; De Clercq E
Antimicrob Agents Chemother; 1998 Jul; 42(7):1568-73. PubMed ID: 9660984
[TBL] [Abstract][Full Text] [Related]
5. Species-dependent and site-specific intestinal metabolism of ester prodrugs.
Van Gelder J; Shafiee M; De Clercq E; Penninckx F; Van den Mooter G; Kinget R; Augustijns P
Int J Pharm; 2000 Sep; 205(1-2):93-100. PubMed ID: 11000545
[TBL] [Abstract][Full Text] [Related]
6. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
[TBL] [Abstract][Full Text] [Related]
7. Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.
Van Gelder J; Deferme S; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Drug Metab Dispos; 2000 Dec; 28(12):1394-6. PubMed ID: 11095573
[TBL] [Abstract][Full Text] [Related]
8. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.
Robbins BL; Srinivas RV; Kim C; Bischofberger N; Fridland A
Antimicrob Agents Chemother; 1998 Mar; 42(3):612-7. PubMed ID: 9517941
[TBL] [Abstract][Full Text] [Related]
9. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
[TBL] [Abstract][Full Text] [Related]
10. Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
Van Gelder J; Witvrouw M; Pannecouque C; Henson G; Bridger G; Naesens L; De Clercq E; Annaert P; Shafiee M; Van den Mooter G; Kinget R; Augustijns P
Int J Pharm; 1999 Sep; 186(2):127-36. PubMed ID: 10486430
[TBL] [Abstract][Full Text] [Related]
11. Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.
Watkins ME; Wring S; Randolph R; Park S; Powell K; Lutz L; Nowakowski M; Ramabhadran R; Domanico PL
J Pharm Sci; 2017 Mar; 106(3):906-919. PubMed ID: 27986599
[TBL] [Abstract][Full Text] [Related]
12. Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.
Eisenberg EJ; He GX; Lee WA
Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1091-8. PubMed ID: 11562963
[TBL] [Abstract][Full Text] [Related]
13. In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Annaert P; Tukker JJ; van Gelder J; Naesens L; de Clercq E; van Den Mooter G; Kinget R; Augustijns P
J Pharm Sci; 2000 Aug; 89(8):1054-62. PubMed ID: 10906729
[TBL] [Abstract][Full Text] [Related]
14. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue.
Gupta D; Varghese Gupta S; Dahan A; Tsume Y; Hilfinger J; Lee KD; Amidon GL
Mol Pharm; 2013 Feb; 10(2):512-22. PubMed ID: 23244438
[TBL] [Abstract][Full Text] [Related]
15. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Zídek Z; Franková D; Holý A
Eur J Pharmacol; 1999 Jul; 376(1-2):91-100. PubMed ID: 10440094
[TBL] [Abstract][Full Text] [Related]
16. Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution.
Oliyai R; Yuan LC; Dahl T
Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1295-8. PubMed ID: 11563007
[TBL] [Abstract][Full Text] [Related]
17. Optimization of the local inhibition of intestinal adenosine deaminase (ADA) by erythro-9-(2-hydroxy-3-nonyl)adenine: enhanced oral delivery of an ADA-activated prodrug for anti-HIV therapy.
Singhal D; Anderson BD
J Pharm Sci; 1998 May; 87(5):578-85. PubMed ID: 9572908
[TBL] [Abstract][Full Text] [Related]
18. Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains.
Srinivas RV; Fridland A
Antimicrob Agents Chemother; 1998 Jun; 42(6):1484-7. PubMed ID: 9624498
[TBL] [Abstract][Full Text] [Related]
19. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
Bak A; Gudmundsson OS; Friis GJ; Siahaan TJ; Borchardt RT
Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
[TBL] [Abstract][Full Text] [Related]
20. Pharmacokinetics and bioavailability of the anti-human immunodeficiency virus nucleotide analog 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Cundy KC; Sueoka C; Lynch GR; Griffin L; Lee WA; Shaw JP
Antimicrob Agents Chemother; 1998 Mar; 42(3):687-90. PubMed ID: 9517952
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
