BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

452 related articles for article (PubMed ID: 10460802)

  • 21. Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs.
    Koyama E; Chiba K; Tani M; Ishizaki T
    J Pharmacol Exp Ther; 1997 Jun; 281(3):1199-210. PubMed ID: 9190854
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6.
    Masimirembwa CM; Hasler JA; Johansson I
    Eur J Clin Pharmacol; 1995; 48(1):35-8. PubMed ID: 7621845
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism.
    Galetin A; Houston JB
    J Pharmacol Exp Ther; 2006 Sep; 318(3):1220-9. PubMed ID: 16763093
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG; Goldstein JA; Lasker JM; Ghanayem BI
    Drug Metab Dispos; 1996 Oct; 24(10):1081-7. PubMed ID: 8894508
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes.
    Kobayashi K; Kogo M; Tani M; Shimada N; Ishizaki T; Numazawa S; Yoshida T; Yamamoto T; Kuroiwa Y; Chiba K
    Drug Metab Dispos; 2001 Jan; 29(1):36-40. PubMed ID: 11124227
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
    Nakajima M; Nakamura S; Tokudome S; Shimada N; Yamazaki H; Yokoi T
    Drug Metab Dispos; 1999 Dec; 27(12):1381-91. PubMed ID: 10570018
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.
    Adedoyin A; Arns PA; Richards WO; Wilkinson GR; Branch RA
    Clin Pharmacol Ther; 1998 Jul; 64(1):8-17. PubMed ID: 9695714
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.
    Ring BJ; Eckstein JA; Gillespie JS; Binkley SN; VandenBranden M; Wrighton SA
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1044-50. PubMed ID: 11356927
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Catalytic specificity of CYP2D isoforms in rat and human.
    Hiroi T; Chow T; Imaoka S; Funae Y
    Drug Metab Dispos; 2002 Sep; 30(9):970-6. PubMed ID: 12167561
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes.
    Olesen OV; Linnet K
    Drug Metab Dispos; 1997 Jun; 25(6):740-4. PubMed ID: 9193876
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6.
    Damkier P; Brøsen K
    Clin Pharmacol Ther; 2000 Aug; 68(2):199-209. PubMed ID: 10976551
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes.
    Hall SD; Guengerich FP; Branch RA; Wilkinson GR
    J Pharmacol Exp Ther; 1987 Jan; 240(1):216-22. PubMed ID: 2879902
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50).
    Gao F; Johnson DL; Ekins S; Janiszewski J; Kelly KG; Meyer RD; West M
    J Biomol Screen; 2002 Aug; 7(4):373-82. PubMed ID: 12230892
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.
    Kronbach T
    Methods Enzymol; 1991; 206():509-17. PubMed ID: 1686064
    [No Abstract]   [Full Text] [Related]  

  • 35. Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
    VandenBranden M; Ring BJ; Binkley SN; Wrighton SA
    Pharmacogenetics; 1996 Feb; 6(1):81-91. PubMed ID: 8845864
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.
    Wienkers LC; Wurden CJ; Storch E; Kunze KL; Rettie AE; Trager WF
    Drug Metab Dispos; 1996 May; 24(5):610-4. PubMed ID: 8723744
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Molecular cloning, expression, and characterization of CYP2D17 from cynomolgus monkey liver.
    Mankowski DC; Laddison KJ; Christopherson PA; Ekins S; Tweedie DJ; Lawton MP
    Arch Biochem Biophys; 1999 Dec; 372(1):189-96. PubMed ID: 10562433
    [TBL] [Abstract][Full Text] [Related]  

  • 38. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.
    Suzuki H; Kneller MB; Haining RL; Trager WF; Rettie AE
    Drug Metab Dispos; 2002 Mar; 30(3):235-9. PubMed ID: 11854139
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
    Yoshimoto K; Echizen H; Chiba K; Tani M; Ishizaki T
    Br J Clin Pharmacol; 1995 Apr; 39(4):421-31. PubMed ID: 7640150
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.
    Goldstein JA; Faletto MB; Romkes-Sparks M; Sullivan T; Kitareewan S; Raucy JL; Lasker JM; Ghanayem BI
    Biochemistry; 1994 Feb; 33(7):1743-52. PubMed ID: 8110777
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 23.