BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 10463601)

  • 1. Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2.
    Bera TK; Viner J; Brinkmann E; Pastan I
    Cancer Res; 1999 Aug; 59(16):4018-22. PubMed ID: 10463601
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Reiter Y; Pai LH; Brinkmann U; Wang QC; Pastan I
    Cancer Res; 1994 May; 54(10):2714-8. PubMed ID: 8168102
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
    Reiter Y; Brinkmann U; Jung SH; Lee B; Kasprzyk PG; King CR; Pastan I
    J Biol Chem; 1994 Jul; 269(28):18327-31. PubMed ID: 7913461
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
    Bera TK; Onda M; Brinkmann U; Pastan I
    J Mol Biol; 1998 Aug; 281(3):475-83. PubMed ID: 9698563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
    Kuan CT; Pastan I
    Biochemistry; 1996 Mar; 35(9):2872-7. PubMed ID: 8608123
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
    Benhar I; Pastan I
    Clin Cancer Res; 1995 Sep; 1(9):1023-9. PubMed ID: 9816075
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer.
    Bera TK; Williams-Gould J; Beers R; Chowdhury P; Pastan I
    Mol Cancer Ther; 2001 Dec; 1(2):79-84. PubMed ID: 12467225
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin.
    Shinohara H; Morita S; Kawai M; Miyamoto A; Sonoda T; Pastan I; Tanigawa N
    J Surg Res; 2002 Feb; 102(2):169-77. PubMed ID: 11796015
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
    Reiter Y; Kreitman RJ; Brinkmann U; Pastan I
    Int J Cancer; 1994 Jul; 58(1):142-9. PubMed ID: 8014011
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
    Benhar I; Reiter Y; Pai LH; Pastan I
    Int J Cancer; 1995 Jul; 62(3):351-5. PubMed ID: 7628878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.
    Kreitman RJ; Margulies I; Stetler-Stevenson M; Wang QC; FitzGerald DJ; Pastan I
    Clin Cancer Res; 2000 Apr; 6(4):1476-87. PubMed ID: 10778980
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.
    Webber KO; Kreitman RJ; Pastan I
    Cancer Res; 1995 Jan; 55(2):318-23. PubMed ID: 7812965
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro.
    Hassan R; Lerner MR; Benbrook D; Lightfoot SA; Brackett DJ; Wang QC; Pastan I
    Clin Cancer Res; 2002 Nov; 8(11):3520-6. PubMed ID: 12429643
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins.
    Reiter Y; Pastan I
    Clin Cancer Res; 1996 Feb; 2(2):245-52. PubMed ID: 9816166
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity.
    Nielsen UB; Adams GP; Weiner LM; Marks JD
    Cancer Res; 2000 Nov; 60(22):6434-40. PubMed ID: 11103810
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
    Kobayashi H; Yoo TM; Drumm D; Kim MK; Sun BF; Le N; Webber KO; Pastan I; Waldmann TA; Paik CH; Carrasquillo JA
    Cancer Res; 1997 May; 57(10):1955-61. PubMed ID: 9157991
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.
    Bang S; Nagata S; Onda M; Kreitman RJ; Pastan I
    Clin Cancer Res; 2005 Feb; 11(4):1545-50. PubMed ID: 15746059
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability.
    Bera TK; Pastan I
    Bioconjug Chem; 1998; 9(6):736-43. PubMed ID: 9815167
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.
    Salvatore G; Beers R; Margulies I; Kreitman RJ; Pastan I
    Clin Cancer Res; 2002 Apr; 8(4):995-1002. PubMed ID: 11948105
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
    Reiter Y; Wright AF; Tonge DW; Pastan I
    Int J Cancer; 1996 Jul; 67(1):113-23. PubMed ID: 8690511
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.