BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 10465404)

  • 1. Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.
    Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L; Giocanti N; Sadri R; Favaudon V
    Bioorg Med Chem; 1999 Jul; 7(7):1281-93. PubMed ID: 10465404
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
    Meijer L; Borgne A; Mulner O; Chong JP; Blow JJ; Inagaki N; Inagaki M; Delcros JG; Moulinoux JP
    Eur J Biochem; 1997 Jan; 243(1-2):527-36. PubMed ID: 9030781
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells.
    Iseki H; Ko TC; Xue XY; Seapan A; Hellmich MR; Townsend CM
    Surgery; 1997 Aug; 122(2):187-94; discussion 194-5. PubMed ID: 9288122
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells.
    David-Pfeuty T
    Oncogene; 1999 Dec; 18(52):7409-22. PubMed ID: 10602500
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
    Atienza C; Elliott MJ; Dong YB; Yang HL; Stilwell A; Liu TJ; McMasters KM
    Int J Mol Med; 2000 Jul; 6(1):55-63. PubMed ID: 10851267
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity.
    Alessi F; Quarta S; Savio M; Riva F; Rossi L; Stivala LA; Scovassi AI; Meijer L; Prosperi E
    Exp Cell Res; 1998 Nov; 245(1):8-18. PubMed ID: 9828096
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological activity of olomoucine II.
    Krystof V; Lenobel R; Havlícek L; Kuzma M; Strnad M
    Bioorg Med Chem Lett; 2002 Nov; 12(22):3283-6. PubMed ID: 12392733
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cellular effects of olomoucine in human lymphoma cells differing in p53 function.
    Fan S; Duba DE; O'Connor PM
    Chemotherapy; 1999; 45(6):437-45. PubMed ID: 10567774
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of cyclin-dependent kinases by purine analogues.
    Veselý J; Havlicek L; Strnad M; Blow JJ; Donella-Deana A; Pinna L; Letham DS; Kato J; Detivaud L; Leclerc S
    Eur J Biochem; 1994 Sep; 224(2):771-86. PubMed ID: 7925396
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.
    Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L
    Bioorg Med Chem Lett; 1998 Apr; 8(7):793-8. PubMed ID: 9871543
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological activities of C-2, N-9 substituted 6-benzylaminopurine derivatives as cyclin-dependent kinase inhibitor.
    Oh CH; Lee SC; Lee KS; Woo ER; Hong CY; Yang BS; Baek DJ; Cho JH
    Arch Pharm (Weinheim); 1999 Jun; 332(6):187-90. PubMed ID: 10399486
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
    Arris CE; Boyle FT; Calvert AH; Curtin NJ; Endicott JA; Garman EF; Gibson AE; Golding BT; Grant S; Griffin RJ; Jewsbury P; Johnson LN; Lawrie AM; Newell DR; Noble ME; Sausville EA; Schultz R; Yu W
    J Med Chem; 2000 Jul; 43(15):2797-804. PubMed ID: 10956187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics.
    Schutte B; Nieland L; van Engeland M; Henfling ME; Meijer L; Ramaekers FC
    Exp Cell Res; 1997 Oct; 236(1):4-15. PubMed ID: 9344580
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
    Legraverend M; Tunnah P; Noble M; Ducrot P; Ludwig O; Grierson DS; Leost M; Meijer L; Endicott J
    J Med Chem; 2000 Apr; 43(7):1282-92. PubMed ID: 10753466
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity.
    Iseki H; Ko TC; Xue XY; Seapan A; Townsend CM
    J Gastrointest Surg; 1998; 2(1):36-43. PubMed ID: 9841966
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
    De Azevedo WF; Leclerc S; Meijer L; Havlicek L; Strnad M; Kim SH
    Eur J Biochem; 1997 Jan; 243(1-2):518-26. PubMed ID: 9030780
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors.
    Ruetz S; Fabbro D; Zimmermann J; Meyer T; Gray N
    Curr Med Chem Anticancer Agents; 2003 Jan; 3(1):1-14. PubMed ID: 12678910
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
    Abraham RT; Acquarone M; Andersen A; Asensi A; Bellé R; Berger F; Bergounioux C; Brunn G; Buquet-Fagot C; Fagot D
    Biol Cell; 1995; 83(2-3):105-20. PubMed ID: 7549905
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design of potent CDK1 inhibitors derived from olomoucine.
    Furet P; Zimmermann J; Capraro HG; Meyer T; Imbach P
    J Comput Aided Mol Des; 2000 Jul; 14(5):403-9. PubMed ID: 10896313
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions.
    Glab N; Labidi B; Qin LX; Trehin C; Bergounioux C; Meijer L
    FEBS Lett; 1994 Oct; 353(2):207-11. PubMed ID: 7523194
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.