BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 10468017)

  • 1. Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier.
    de Vrueh RL; Rump ET; Sliedregt LA; Biessen EA; van Berkel TJ; Bijsterbosch MK
    Pharm Res; 1999 Aug; 16(8):1179-85. PubMed ID: 10468017
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.
    de Vrueh RL; Rump ET; van De Bilt E; van Veghel R; Balzarini J; Biessen EA; van Berkel TJ; Bijsterbosch MK
    Antimicrob Agents Chemother; 2000 Mar; 44(3):477-83. PubMed ID: 10681306
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus.
    Bijsterbosch MK; Ying C; de Vrueh RL; de Clercq E; Biessen EA; Neyts J; van Berkel TJ
    Mol Pharmacol; 2001 Sep; 60(3):521-7. PubMed ID: 11502883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
    Biessen EA; Valentijn AR; De Vrueh RL; Van De Bilt E; Sliedregt LA; Prince P; Bijsterbosch MK; Van Boom JH; Van Der Marel GA; Abrahams PJ; Van Berkel TJ
    FASEB J; 2000 Sep; 14(12):1784-92. PubMed ID: 10973928
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Specific targeting of a lipophilic prodrug of iododeoxyuridine to parenchymal liver cells using lactosylated reconstituted high density lipoprotein particles.
    Bijsterbosch MK; van de Bilt H; van Berkel TJ
    Biochem Pharmacol; 1996 Jul; 52(1):113-21. PubMed ID: 8678894
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
    Naesens L; Balzarini J; Bischofberger N; De Clercq E
    Antimicrob Agents Chemother; 1996 Jan; 40(1):22-8. PubMed ID: 8787873
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of the dioleoyl derivative of iododeoxyuridine and its incorporation into reconstituted high density lipoprotein particles.
    Bijsterbosch MK; Schouten D; van Berkel TJ
    Biochemistry; 1994 Nov; 33(47):14073-80. PubMed ID: 7947817
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.
    Lin CC; Yeh LT; Vitarella D; Hong Z; Erion MD
    Antivir Chem Chemother; 2004 Nov; 15(6):307-17. PubMed ID: 15646644
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
    Starrett JE; Tortolani DR; Hitchcock MJ; Martin JC; Mansuri MM
    Antiviral Res; 1992 Sep; 19(3):267-73. PubMed ID: 1332606
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
    Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
    Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
    Hatse S; De Clercq E; Balzarini J
    Mol Pharmacol; 1998 Nov; 54(5):907-17. PubMed ID: 9804626
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
    Cundy KC; Fishback JA; Shaw JP; Lee ML; Soike KF; Visor GC; Lee WA
    Pharm Res; 1994 Jun; 11(6):839-43. PubMed ID: 7937523
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.
    Robbins BL; Connelly MC; Marshall DR; Srinivas RV; Fridland A
    Mol Pharmacol; 1995 Feb; 47(2):391-7. PubMed ID: 7870049
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
    Starrett JE; Tortolani DR; Russell J; Hitchcock MJ; Whiterock V; Martin JC; Mansuri MM
    J Med Chem; 1994 Jun; 37(12):1857-64. PubMed ID: 8021925
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
    Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
    Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cell-protecting effect against herpes simplex virus-1 and cellular metabolism of 9-(2-phosphonylmethoxyethyl)adenine in HeLa S3 cells.
    Cerny J; Foster SA; Cheng YC
    Mol Pharmacol; 1992 Sep; 42(3):537-44. PubMed ID: 1328849
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.
    Hatse S; Naesens L; Degrève B; Segers C; Vandeputte M; Waer M; De Clercq E; Balzarini J
    Int J Cancer; 1998 May; 76(4):595-600. PubMed ID: 9590139
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus.
    Rossi L; Serafini S; Cappellacci L; Balestra E; Brandi G; Schiavano GF; Franchetti P; Grifantini M; Perno CF; Magnani M
    J Antimicrob Chemother; 2001 Jun; 47(6):819-27. PubMed ID: 11389114
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
    Rossi L; Dominici S; Serafini S; Casabianca A; Cerasi A; Chiarantini L; Celeste AG; Cappellacci L; Franchetti P; Grifantini M; Magnani M
    J Antimicrob Chemother; 2002 Sep; 50(3):365-74. PubMed ID: 12205061
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus.
    Perno CF; Santoro N; Balestra E; Aquaro S; Cenci A; Lazzarino G; Di Pierro D; Tavazzi B; Balzarini J; Garaci E; Grimaldi S; Caliò R
    Antiviral Res; 1997 Feb; 33(3):153-64. PubMed ID: 9037372
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.