BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 10470377)

  • 1. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
    Qi H; Atkinson I; Xiao S; Choi YJ; Tobimatsu T; Shane B
    Adv Enzyme Regul; 1999; 39():263-73. PubMed ID: 10470377
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene.
    Chen L; Qi H; Korenberg J; Garrow TA; Choi YJ; Shane B
    J Biol Chem; 1996 May; 271(22):13077-87. PubMed ID: 8662720
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
    Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondrion.
    Lin BF; Shane B
    J Biol Chem; 1994 Apr; 269(13):9705-13. PubMed ID: 8144561
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-gamma-glutamate synthetase.
    Lin BF; Huang RF; Shane B
    J Biol Chem; 1993 Oct; 268(29):21674-9. PubMed ID: 8408020
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.
    Osborne CB; Lowe KE; Shane B
    J Biol Chem; 1993 Oct; 268(29):21657-64. PubMed ID: 8408018
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity.
    Kim JS; Lowe KE; Shane B
    J Biol Chem; 1993 Oct; 268(29):21680-5. PubMed ID: 8408021
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.
    Lawrence SA; Titus SA; Ferguson J; Heineman AL; Taylor SM; Moran RG
    J Biol Chem; 2014 Oct; 289(42):29386-96. PubMed ID: 25164808
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.
    Lowe KE; Osborne CB; Lin BF; Kim JS; Hsu JC; Shane B
    J Biol Chem; 1993 Oct; 268(29):21665-73. PubMed ID: 8408019
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
    Raz S; Stark M; Assaraf YG
    Drug Resist Updat; 2016 Sep; 28():43-64. PubMed ID: 27620954
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Stark M; Wichman C; Avivi I; Assaraf YG
    Blood; 2009 Apr; 113(18):4362-9. PubMed ID: 19131550
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania.
    El-Fadili A; Richard D; Kündig C; Ouellette M
    Biochem Pharmacol; 2003 Sep; 66(6):999-1008. PubMed ID: 12963486
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines.
    McGuire JJ; Russell CA
    Oncol Res; 1998; 10(4):193-200. PubMed ID: 9778690
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.
    McGuire JJ; Russell CA; Balinska M
    J Biol Chem; 2000 Apr; 275(17):13012-6. PubMed ID: 10777604
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug.
    Kim JS; Shane B
    J Biol Chem; 1994 Apr; 269(13):9714-20. PubMed ID: 8144562
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
    Aghi M; Kramm CM; Breakefield XO
    J Natl Cancer Inst; 1999 Jul; 91(14):1233-41. PubMed ID: 10413425
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme.
    Roy K; Mitsugi K; Sirotnak FM
    J Biol Chem; 1996 Sep; 271(39):23820-7. PubMed ID: 8798611
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and characterization of genetic variation in the folylpolyglutamate synthase gene.
    Leil TA; Endo C; Adjei AA; Dy GK; Salavaggione OE; Reid JR; Ames MM; Adjei AA
    Cancer Res; 2007 Sep; 67(18):8772-82. PubMed ID: 17875718
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells.
    Leclerc GJ; Leclerc GM; Kinser TT; Barredo JC
    BMC Cancer; 2006 May; 6():132. PubMed ID: 16707018
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
    Roy K; Mitsugi K; Sirlin S; Shane B; Sirotnak FM
    J Biol Chem; 1995 Nov; 270(45):26918-22. PubMed ID: 7592937
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.