508 related articles for article (PubMed ID: 10471271)
1. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
[TBL] [Abstract][Full Text] [Related]
2. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
3. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
[TBL] [Abstract][Full Text] [Related]
4. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
[TBL] [Abstract][Full Text] [Related]
5. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
6. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Selkoe DJ
Proc Natl Acad Sci U S A; 2001 Sep; 98(20):11039-41. PubMed ID: 11572965
[TBL] [Abstract][Full Text] [Related]
7. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Wolfe MS; Xia W; Moore CL; Leatherwood DD; Ostaszewski B; Rahmati T; Donkor IO; Selkoe DJ
Biochemistry; 1999 Apr; 38(15):4720-7. PubMed ID: 10200159
[TBL] [Abstract][Full Text] [Related]
8. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
[TBL] [Abstract][Full Text] [Related]
9. Intramembrane proteolysis by presenilin and presenilin-like proteases.
Xia W; Wolfe MS
J Cell Sci; 2003 Jul; 116(Pt 14):2839-44. PubMed ID: 12808018
[TBL] [Abstract][Full Text] [Related]
10. Presenilin function and gamma-secretase activity.
Brunkan AL; Goate AM
J Neurochem; 2005 May; 93(4):769-92. PubMed ID: 15857382
[TBL] [Abstract][Full Text] [Related]
11. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
12. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
13. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
[TBL] [Abstract][Full Text] [Related]
14. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
[TBL] [Abstract][Full Text] [Related]
15. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
[TBL] [Abstract][Full Text] [Related]
16. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
17. Nicastrin binds to membrane-tethered Notch.
Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
[TBL] [Abstract][Full Text] [Related]
18. [Molecular basics of Alzheimer's disease].
Grigorenko AP; Rogaev EI
Mol Biol (Mosk); 2007; 41(2):331-45. PubMed ID: 17514900
[TBL] [Abstract][Full Text] [Related]
19. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
20. [Pathogenesis of Alzheimer's disease: implications from amyloid research front].
Iwatsubo T
Rinsho Shinkeigaku; 2004 Nov; 44(11):768-70. PubMed ID: 15651286
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
