BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

116 related articles for article (PubMed ID: 10482440)

  • 1. A novel molecular modelling study of inhibitors of the 17alpha-hydroxylase component of the enzyme system 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).
    Ahmed S
    Bioorg Med Chem; 1999 Aug; 7(8):1487-96. PubMed ID: 10482440
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP; Shahid I; Olusanjo MS; Patel CH; Dhanani S; Ahmed S
    J Steroid Biochem Mol Biol; 2008 Jul; 111(1-2):117-27. PubMed ID: 18620055
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).
    Shahid I; Patel CH; Dhanani S; Owen CP; Ahmed S
    J Steroid Biochem Mol Biol; 2008 May; 110(1-2):18-29. PubMed ID: 18407491
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP; Dhanani S; Patel CH; Shahid I; Ahmed S
    Bioorg Med Chem Lett; 2006 Aug; 16(15):4011-5. PubMed ID: 16750362
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17alpha-hydroxylase and 17,20-lyase.
    Ahmed S
    Biochem Biophys Res Commun; 2004 Apr; 316(3):595-8. PubMed ID: 15033441
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Patel CH; Dhanani S; Owen CP; Ahmed S
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4752-6. PubMed ID: 16870430
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Modeling study of some inhibitors of 17,20-lyase, a component of the enzyme 17 alpha-hydroxylase/17,20-lyase: a novel approach.
    Ahmed S; Keane J
    Biochem Biophys Res Commun; 1998 Dec; 253(2):273-6. PubMed ID: 9878527
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.
    Owen CP; Shahid I; Lee WY; Ahmed S
    Bioorg Med Chem Lett; 2010 Sep; 20(17):5345-8. PubMed ID: 20675132
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).
    Ahmed S; Shahid I; Dhanani S; Owen CP
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4698-701. PubMed ID: 19608417
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, 17α-hydroxylase-C
    Banday AH; Shameem SA; Banday JA; Ganaie BA
    Anticancer Agents Med Chem; 2018; 18(13):1919-1926. PubMed ID: 29697032
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review.
    Owen CP
    Anticancer Agents Med Chem; 2009 Jul; 9(6):613-26. PubMed ID: 19601745
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
    Hille UE; Hu Q; Vock C; Negri M; Bartels M; Müller-Vieira U; Lauterbach T; Hartmann RW
    Eur J Med Chem; 2009 Jul; 44(7):2765-75. PubMed ID: 19211174
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Investigations on inhibitors of human 17 alpha-hydroxylase-17,20-lyase and their interactions with the enzyme. Molecular modelling of 17 alpha-hydroxylase-17,20-lyase, Part II.
    Schappach A; Höltje HD
    Pharmazie; 2001 Nov; 56(11):835-42. PubMed ID: 11817165
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds.
    Szabó N; Ajduković JJ; Djurendić EA; Sakač MN; Ignáth I; Gardi J; Mahmoud G; Klisurić OR; Jovanović-Šanta S; Penov Gaši KM; Szécsi M
    Acta Biol Hung; 2015 Mar; 66(1):41-51. PubMed ID: 25740437
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.
    Van Den Akker EL; Koper JW; Boehmer AL; Themmen AP; Verhoef-Post M; Timmerman MA; Otten BJ; Drop SL; De Jong FH
    J Clin Endocrinol Metab; 2002 Dec; 87(12):5714-21. PubMed ID: 12466376
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
    Auchus RJ; Miller WL
    Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.
    Laughton CA; Neidle S
    J Med Chem; 1990 Nov; 33(11):3055-60. PubMed ID: 2231605
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
    Clement OO; Freeman CM; Hartmann RW; Handratta VD; Vasaitis TS; Brodie AM; Njar VC
    J Med Chem; 2003 Jun; 46(12):2345-51. PubMed ID: 12773039
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
    Blass BE; Iyer P; Abou-Gharbia M; Childers WE; Gordon JC; Ramanjulu M; Morton G; Arumugam P; Boruwa J; Ellingboe J; Mitra S; Reddy Nimmareddy R; Paliwal S; Rajasekhar J; Shivakumar S; Srivastava P; Tangirala RS; Venkataramanaiah K; Bobbala R; Yanamandra M; Krishnakanth Reddy L
    Bioorg Med Chem Lett; 2018 Jul; 28(13):2270-2274. PubMed ID: 29803730
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.
    Salvador JA; Pinto RM; Silvestre SM
    J Steroid Biochem Mol Biol; 2013 Sep; 137():199-222. PubMed ID: 23688836
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.