BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 10486147)

  • 1. Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis.
    Korotchkina LG; Showkat Ali M; Patel MS
    Arch Biochem Biophys; 1999 Sep; 369(2):277-87. PubMed ID: 10486147
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: role of methionine-181, proline-188, and arginine-349 in the alpha subunit.
    Tripatara A; Korotchkina LG; Patel MS
    Arch Biochem Biophys; 1999 Jul; 367(1):39-50. PubMed ID: 10375397
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Systematic study of the six cysteines of the E1 subunit of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: none is essential for activity.
    Nemeria N; Volkov A; Brown A; Yi J; Zipper L; Guest JR; Jordan F
    Biochemistry; 1998 Jan; 37(3):911-22. PubMed ID: 9454581
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Protein-protein interaction revealed by NMR T(2) relaxation experiments: the lipoyl domain and E1 component of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.
    Howard MJ; Chauhan HJ; Domingo GJ; Fuller C; Perham RN
    J Mol Biol; 2000 Jan; 295(4):1023-37. PubMed ID: 10656808
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
    Liu S; Gong X; Yan X; Peng T; Baker JC; Li L; Robben PM; Ravindran S; Andersson LA; Cole AB; Roche TE
    Arch Biochem Biophys; 2001 Feb; 386(2):123-35. PubMed ID: 11368334
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Expression of pyruvate dehydrogenase isoforms during the aerobic/anaerobic transition in the development of the parasitic nematode Ascaris suum: altered stoichiometry of phosphorylation/inactivation.
    Huang YJ; Walker D; Chen W; Klingbeil M; Komuniecki R
    Arch Biochem Biophys; 1998 Apr; 352(2):263-70. PubMed ID: 9587415
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.
    Seifert F; Ciszak E; Korotchkina L; Golbik R; Spinka M; Dominiak P; Sidhu S; Brauer J; Patel MS; Tittmann K
    Biochemistry; 2007 May; 46(21):6277-87. PubMed ID: 17474719
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation.
    Seifert F; Golbik R; Brauer J; Lilie H; Schröder-Tittmann K; Hinze E; Korotchkina LG; Patel MS; Tittmann K
    Biochemistry; 2006 Oct; 45(42):12775-85. PubMed ID: 17042496
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.
    Patel MS; Korotchkina LG
    Exp Mol Med; 2001 Dec; 33(4):191-7. PubMed ID: 11795479
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate.
    Flournoy DS; Frey PA
    Biochemistry; 1989 Dec; 28(25):9594-602. PubMed ID: 2514803
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bromopyruvate as an active-site-directed inhibitor of the pyruvate dehydrogenase multienzyme complex from Escherichia coli.
    Lowe PN; Perham RN
    Biochemistry; 1984 Jan; 23(1):91-7. PubMed ID: 6362725
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2-Oxo-3-alkynoic acids, universal mechanism-based inactivators of thiamin diphosphate-dependent decarboxylases: synthesis and evidence for potent inactivation of the pyruvate dehydrogenase multienzyme complex.
    Brown A; Nemeria N; Yi J; Zhang D; Jordan WB; Machado RS; Guest JR; Jordan F
    Biochemistry; 1997 Jul; 36(26):8071-81. PubMed ID: 9201955
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes.
    Fries M; Jung HI; Perham RN
    Biochemistry; 2003 Jun; 42(23):6996-7002. PubMed ID: 12795594
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient.
    Jacobia SJ; Korotchkina LG; Patel MS
    Biochim Biophys Acta; 2002 Jan; 1586(1):32-42. PubMed ID: 11781147
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
    Bao H; Kasten SA; Yan X; Roche TE
    Biochemistry; 2004 Oct; 43(42):13432-41. PubMed ID: 15491150
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure.
    Korotchkina LG; Ciszak EM; Patel MS
    Arch Biochem Biophys; 2004 Sep; 429(2):171-9. PubMed ID: 15313220
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulatory effect of thiamin pyrophosphate on pig heart pyruvate dehydrogenase complex.
    Strumilo S; Czerniecki J; Dobrzyn P
    Biochem Biophys Res Commun; 1999 Mar; 256(2):341-5. PubMed ID: 10079185
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of the tryptophan residue in the thiamin pyrophosphate binding site of mammalian pyruvate dehydrogenase.
    Ali MS; Shenoy BC; Eswaran D; Andersson LA; Roche TE; Patel MS
    J Biol Chem; 1995 Mar; 270(9):4570-4. PubMed ID: 7876227
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli.
    Jones DD; Horne HJ; Reche PA; Perham RN
    J Mol Biol; 2000 Jan; 295(2):289-306. PubMed ID: 10623527
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Effect of C-4'-modification of thiamine pyrophosphate on its coenzyme activity in the oxidative decarboxylation of pyruvic acid reaction].
    Severin SE; Khaĭlova LS; Bernkhardt R
    Ukr Biokhim Zh; 1976; 48(4):503-9. PubMed ID: 982621
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.