BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 10497236)

  • 1. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
    Steiner H; Duff K; Capell A; Romig H; Grim MG; Lincoln S; Hardy J; Yu X; Picciano M; Fechteler K; Citron M; Kopan R; Pesold B; Keck S; Baader M; Tomita T; Iwatsubo T; Baumeister R; Haass C
    J Biol Chem; 1999 Oct; 274(40):28669-73. PubMed ID: 10497236
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
    Steiner H; Revesz T; Neumann M; Romig H; Grim MG; Pesold B; Kretzschmar HA; Hardy J; Holton JL; Baumeister R; Houlden H; Haass C
    J Biol Chem; 2001 Mar; 276(10):7233-9. PubMed ID: 11084029
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
    Saura CA; Tomita T; Soriano S; Takahashi M; Leem JY; Honda T; Koo EH; Iwatsubo T; Thinakaran G
    J Biol Chem; 2000 Jun; 275(22):17136-42. PubMed ID: 10748144
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
    Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
    Biochemistry; 1999 Oct; 38(41):13602-9. PubMed ID: 10521267
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA; Schenk DB; Basi GS
    Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
    Xia W; Zhang J; Kholodenko D; Citron M; Podlisny MB; Teplow DB; Haass C; Seubert P; Koo EH; Selkoe DJ
    J Biol Chem; 1997 Mar; 272(12):7977-82. PubMed ID: 9065468
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
    Lammich S; Okochi M; Takeda M; Kaether C; Capell A; Zimmer AK; Edbauer D; Walter J; Steiner H; Haass C
    J Biol Chem; 2002 Nov; 277(47):44754-9. PubMed ID: 12223485
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
    Moehlmann T; Winkler E; Xia X; Edbauer D; Murrell J; Capell A; Kaether C; Zheng H; Ghetti B; Haass C; Steiner H
    Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8025-30. PubMed ID: 12048239
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
    Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido TC; Maruyama K; Iwatsubo T
    J Biol Chem; 1998 Aug; 273(33):21153-60. PubMed ID: 9694871
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
    Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.
    Takeda K; Araki W; Tabira T
    Eur J Neurosci; 2004 Jan; 19(2):258-264. PubMed ID: 14725619
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
    Herreman A; Hartmann D; Annaert W; Saftig P; Craessaerts K; Serneels L; Umans L; Schrijvers V; Checler F; Vanderstichele H; Baekelandt V; Dressel R; Cupers P; Huylebroeck D; Zwijsen A; Van Leuven F; De Strooper B
    Proc Natl Acad Sci U S A; 1999 Oct; 96(21):11872-7. PubMed ID: 10518543
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.