BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

824 related articles for article (PubMed ID: 10499632)

  • 21. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H; Niethammer D; Jackson RC
    Cancer Res; 1983 Nov; 43(11):5286-92. PubMed ID: 6225514
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
    Pizzorno G; Moroson BA; Cashmore AR; Russello O; Mayer JR; Galivan J; Bunni MA; Priest DG; Beardsley GP
    Cancer Res; 1995 Feb; 55(3):566-73. PubMed ID: 7834626
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.
    McGuire JJ; Haile WH; Yeh CC
    Cancer Res; 2006 Apr; 66(7):3836-44. PubMed ID: 16585211
    [TBL] [Abstract][Full Text] [Related]  

  • 24. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y; Ohnuma T
    Mt Sinai J Med; 1992 Oct; 59(5):419-24. PubMed ID: 1435841
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
    Jansen G; Westerhof GR; Kathmann I; Rademaker BC; Rijksen G; Schornagel JH
    Cancer Res; 1989 May; 49(9):2455-9. PubMed ID: 2706633
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mode of action of methotrexate-albumin in a human T-cell leukemia line and activity against an MTX-resistant clone.
    Weigand M; Hartung G; Roboz J; Sieger S; Wolf M; Sinn H; Schrenk HH; Wiessler M; Frei E
    Anticancer Drug Des; 2001; 16(4-5):227-37. PubMed ID: 12049481
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
    Jackman AL; Kimbell R; Aherne GW; Brunton L; Jansen G; Stephens TC; Smith MN; Wardleworth JM; Boyle FT
    Clin Cancer Res; 1997 Jun; 3(6):911-21. PubMed ID: 9815766
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
    Barnes MJ; Taylor GA; Newell DR
    Biochem Pharmacol; 2000 Feb; 59(4):321-8. PubMed ID: 10644039
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
    Westerhof GR; Rijnboutt S; Schornagel JH; Pinedo HM; Peters GJ; Jansen G
    Cancer Res; 1995 Sep; 55(17):3795-802. PubMed ID: 7641196
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
    Smith SG; Lehman NL; Moran RG
    Cancer Res; 1993 Dec; 53(23):5697-706. PubMed ID: 8242626
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
    Chen VJ; Bewley JR; Andis SL; Schultz RM; Iversen PW; Shih C; Mendelsohn LG; Seitz DE; Tonkinson JL
    Semin Oncol; 1999 Apr; 26(2 Suppl 6):48-54. PubMed ID: 10598555
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
    McGuire JJ; Heitzman KJ; Haile WH; Russell CA; McCloskey DE; Piper JR
    Leukemia; 1993 Dec; 7(12):1996-2003. PubMed ID: 8255099
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
    McGuire JJ; Canestrari JG; Nagel GS
    Int J Oncol; 1999 Dec; 15(6):1245-50. PubMed ID: 10568835
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
    Mini E; Moroson BA; Franco CT; Bertino JR
    Cancer Res; 1985 Jan; 45(1):325-30. PubMed ID: 3855284
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
    Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation.
    McGuire JJ; Graber M; Licato N; Vincenz C; Coward JK; Nimec Z; Galivan J
    Cancer Res; 1989 Aug; 49(16):4517-25. PubMed ID: 2472880
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR; Schornagel JH; Kathmann I; Jackman AL; Rosowsky A; Forsch RA; Hynes JB; Boyle FT; Peters GJ; Pinedo HM
    Mol Pharmacol; 1995 Sep; 48(3):459-71. PubMed ID: 7565626
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.
    Schultz RM; Patel VF; Worzalla JF; Shih C
    Anticancer Res; 1999; 19(1A):437-43. PubMed ID: 10226579
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
    McCloskey DE; McGuire JJ; Russell CA; Rowan BG; Bertino JR; Pizzorno G; Mini E
    J Biol Chem; 1991 Apr; 266(10):6181-7. PubMed ID: 2007575
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
    Takemura Y; Kobayashi H; Gibson W; Kimbell R; Miyachi H; Jackman AL
    Int J Cancer; 1996 Mar; 66(1):29-36. PubMed ID: 8608962
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 42.