BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 10500502)

  • 1. Cellular uptake of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).
    Haldane A; Finlay GJ; Hay MP; Denny WA; Baguley BC
    Anticancer Drug Des; 1999 Jun; 14(3):275-80. PubMed ID: 10500502
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Topoisomerase I/II selectivity among derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).
    Bridewell DJ; Finlay GJ; Baguley BC
    Anticancer Drug Des; 2001 Dec; 16(6):317-24. PubMed ID: 12375884
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells.
    Hicks KO; Pruijn FB; Baguley BC; Wilson WR
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1088-98. PubMed ID: 11356933
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.
    Spicer JA; Finlay GJ; Baguley BC; Velea L; Graves DE; Denny WA
    Anticancer Drug Des; 1999 Feb; 14(1):37-45. PubMed ID: 10363026
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues.
    Osman S; Rowlinson-Busza G; Luthra SK; Aboagye EO; Brown GD; Brady F; Myers R; Gamage SA; Denny WA; Baguley BC; Price PM
    Cancer Res; 2001 Apr; 61(7):2935-44. PubMed ID: 11306471
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
    Spicer JA; Gamage SA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(12):1919-29. PubMed ID: 9191970
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.
    Bridewell DJ; Finlay GJ; Baguley BC
    Cancer Chemother Pharmacol; 1999; 43(4):302-8. PubMed ID: 10071981
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
    Todd AK; Adams A; Thorpe JH; Denny WA; Wakelin LP; Cardin CJ
    J Med Chem; 1999 Feb; 42(4):536-40. PubMed ID: 10052960
    [No Abstract]   [Full Text] [Related]  

  • 10. In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance.
    Finlay GJ; Marshall E; Matthews JH; Paull KD; Baguley BC
    Cancer Chemother Pharmacol; 1993; 31(5):401-6. PubMed ID: 8381721
    [TBL] [Abstract][Full Text] [Related]  

  • 11. From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives.
    Finlay GJ; Riou JF; Baguley BC
    Eur J Cancer; 1996 Apr; 32A(4):708-14. PubMed ID: 8695277
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
    Adams A; Guss JM; Collyer CA; Denny WA; Wakelin LP
    Biochemistry; 1999 Jul; 38(29):9221-33. PubMed ID: 10413496
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A comparison of the effects of aphidicolin and other inhibitors on topoisomerase II-directed cytotoxic drugs.
    Haldane A; Finlay GJ; Baguley BC
    Oncol Res; 1993; 5(3):133-8. PubMed ID: 8260750
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
    Deady LW; Kaye AJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(13):2040-6. PubMed ID: 9207945
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in rats and humans prior to phase I clinical trials.
    Osman S; Luthra SK; Brady F; Hume SP; Brown G; Harte RJ; Matthews JC; Denny WA; Baguley BC; Jones T; Price PM
    Cancer Res; 1997 Jun; 57(11):2172-80. PubMed ID: 9187117
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines.
    Wolf SJ; Wakelin LP; He Z; Stewart BW; Catchpoole DR
    Cancer Chemother Pharmacol; 2009 Nov; 64(6):1059-69. PubMed ID: 19277661
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells.
    Padget K; Stewart A; Charlton P; Tilby MJ; Austin CA
    Biochem Pharmacol; 2000 Sep; 60(6):817-21. PubMed ID: 10930536
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions.
    Finlay GJ; Atwell GJ; Baguley BC
    Oncol Res; 1999; 11(6):249-54. PubMed ID: 10691026
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines: implications for overcoming multidrug resistance towards leukaemia K562/DOX cells.
    Tarasiuk J; Majewska E; Seksek O; Rogacka D; Antonini I; Garnier-Suillerot A; Borowski E
    Biochem Pharmacol; 2004 Nov; 68(9):1815-23. PubMed ID: 15450947
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Topoisomerase II mediated DNA lesions induced by acridine-4-carboxamide and 2-(4-pyridyl)quinoline-8-carboxamide.
    Woynarowski JM; McCarthy K; Reynolds B; Beerman TA; Denny WA
    Anticancer Drug Des; 1994 Feb; 9(1):9-24. PubMed ID: 8141968
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.