These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 10514294)

  • 1. Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties.
    Hu LY; Ryder TR; Rafferty MF; Feng MR; Lotarski SM; Rock DM; Sinz M; Stoehr SJ; Taylor CP; Weber ML; Bowersox SS; Miljanich GP; Millerman E; Wang YX; Szoke BG
    J Med Chem; 1999 Oct; 42(20):4239-49. PubMed ID: 10514294
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.
    Maillard MC; Perlman ME; Amitay O; Baxter D; Berlove D; Connaughton S; Fischer JB; Guo JQ; Hu LY; McBurney RN; Nagy PI; Subbarao K; Yost EA; Zhang L; Durant GJ
    J Med Chem; 1998 Jul; 41(16):3048-61. PubMed ID: 9685245
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia.
    Hu LY; Ryder TR; Rafferty MF; Taylor CP; Feng MR; Kuo BS; Lotarski SM; Miljanich GP; Millerman E; Siebers KM; Szoke BG
    Bioorg Med Chem; 2000 Jun; 8(6):1203-12. PubMed ID: 10896101
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
    Abbadie C; McManus OB; Sun SY; Bugianesi RM; Dai G; Haedo RJ; Herrington JB; Kaczorowski GJ; Smith MM; Swensen AM; Warren VA; Williams B; Arneric SP; Eduljee C; Snutch TP; Tringham EW; Jochnowitz N; Liang A; Euan MacIntyre D; McGowan E; Mistry S; White VV; Hoyt SB; London C; Lyons KA; Bunting PB; Volksdorf S; Duffy JL
    J Pharmacol Exp Ther; 2010 Aug; 334(2):545-55. PubMed ID: 20439438
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
    Vamecq J; Bac P; Herrenknecht C; Maurois P; Delcourt P; Stables JP
    J Med Chem; 2000 Apr; 43(7):1311-9. PubMed ID: 10753468
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.
    Annoura H; Nakanishi K; Toba T; Takemoto N; Imajo S; Miyajima A; Tamura-Horikawa Y; Tamura S
    J Med Chem; 2000 Sep; 43(18):3372-6. PubMed ID: 10978184
    [No Abstract]   [Full Text] [Related]  

  • 7. Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
    Shipe WD; Barrow JC; Yang ZQ; Lindsley CW; Yang FV; Schlegel KA; Shu Y; Rittle KE; Bock MG; Hartman GD; Tang C; Ballard JE; Kuo Y; Adarayan ED; Prueksaritanont T; Zrada MM; Uebele VN; Nuss CE; Connolly TM; Doran SM; Fox SV; Kraus RL; Marino MJ; Graufelds VK; Vargas HM; Bunting PB; Hasbun-Manning M; Evans RM; Koblan KS; Renger JJ
    J Med Chem; 2008 Jul; 51(13):3692-5. PubMed ID: 18540666
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of new 4-arylpiperidines and 4-aryl-4-piperidinols: dual Na(+) and Ca(2+) channel blockers with reduced affinity for dopamine D(2) receptors.
    Annoura H; Nakanishi K; Uesugi M; Fukunaga A; Imajo S; Miyajima A; Tamura-Horikawa Y; Tamura S
    Bioorg Med Chem; 2002 Feb; 10(2):371-83. PubMed ID: 11741786
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants.
    Schenck HA; Lenkowski PW; Choudhury-Mukherjee I; Ko SH; Stables JP; Patel MK; Brown ML
    Bioorg Med Chem; 2004 Mar; 12(5):979-93. PubMed ID: 14980611
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.
    Guzikowski AP; Tamiz AP; Acosta-Burruel M; Hong-Bae S; Cai SX; Hawkinson JE; Keana JF; Kesten SR; Shipp CT; Tran M; Whittemore ER; Woodward RM; Wright JL; Zhou ZL
    J Med Chem; 2000 Mar; 43(5):984-94. PubMed ID: 10715162
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
    Reddy NL; Fan W; Magar SS; Perlman ME; Yost E; Zhang L; Berlove D; Fischer JB; Burke-Howie K; Wolcott T; Durant GJ
    J Med Chem; 1998 Aug; 41(17):3298-302. PubMed ID: 9703475
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Neuronal N-type calcium channel blockers: a series of 4-piperidinylaniline analogs with analgesic activity.
    Hu LY; Ryder TR; Rafferty MF; Siebers KM; Malone T; Chatterjee A; Feng MR; Lotarski SM; Rock DM; Stoehr SJ; Taylor CP; Weber ML; Miljanich GP; Millerman E; Szoke BG
    Drug Des Discov; 2000; 17(1):85-93. PubMed ID: 10928451
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.
    Berecki G; Motin L; Haythornthwaite A; Vink S; Bansal P; Drinkwater R; Wang CI; Moretta M; Lewis RJ; Alewood PF; Christie MJ; Adams DJ
    Mol Pharmacol; 2010 Feb; 77(2):139-48. PubMed ID: 19892914
    [TBL] [Abstract][Full Text] [Related]  

  • 14. (S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.
    Song Y; Bowersox SS; Connor DT; Dooley DJ; Lotarski SM; Malone T; Miljanich G; Millerman E; Rafferty MF; Rock D; Roth BD; Schmidt J; Stoehr S; Szoke BG; Taylor C; Vartanian M; Wang YX
    J Med Chem; 2000 Sep; 43(19):3474-7. PubMed ID: 11000000
    [No Abstract]   [Full Text] [Related]  

  • 15. Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.
    Gitto R; Caruso R; Pagano B; De Luca L; Citraro R; Russo E; De Sarro G; Chimirri A
    J Med Chem; 2006 Sep; 49(18):5618-22. PubMed ID: 16942035
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.
    Kraus RL; Li Y; Gregan Y; Gotter AL; Uebele VN; Fox SV; Doran SM; Barrow JC; Yang ZQ; Reger TS; Koblan KS; Renger JJ
    J Pharmacol Exp Ther; 2010 Nov; 335(2):409-17. PubMed ID: 20682849
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
    Shao PP; Ye F; Chakravarty PK; Varughese DJ; Herrington JB; Dai G; Bugianesi RM; Haedo RJ; Swensen AM; Warren VA; Smith MM; Garcia ML; McManus OB; Lyons KA; Li X; Green M; Jochnowitz N; McGowan E; Mistry S; Sun SY; Abbadie C; Kaczorowski GJ; Duffy JL
    J Med Chem; 2012 Nov; 55(22):9847-55. PubMed ID: 23098566
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.
    Teodori E; Baldi E; Dei S; Gualtieri F; Romanelli MN; Scapecchi S; Bellucci C; Ghelardini C; Matucci R
    J Med Chem; 2004 Nov; 47(24):6070-81. PubMed ID: 15537361
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
    Benes J; Parada A; Figueiredo AA; Alves PC; Freitas AP; Learmonth DA; Cunha RA; Garrett J; Soares-da-Silva P
    J Med Chem; 1999 Jul; 42(14):2582-7. PubMed ID: 10411478
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
    Yang ZQ; Barrow JC; Shipe WD; Schlegel KA; Shu Y; Yang FV; Lindsley CW; Rittle KE; Bock MG; Hartman GD; Uebele VN; Nuss CE; Fox SV; Kraus RL; Doran SM; Connolly TM; Tang C; Ballard JE; Kuo Y; Adarayan ED; Prueksaritanont T; Zrada MM; Marino MJ; Graufelds VK; DiLella AG; Reynolds IJ; Vargas HM; Bunting PB; Woltmann RF; Magee MM; Koblan KS; Renger JJ
    J Med Chem; 2008 Oct; 51(20):6471-7. PubMed ID: 18817368
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.