These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

245 related articles for article (PubMed ID: 10535753)

  • 1. Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
    Zhao R; Gao F; Goldman ID
    Biochem Pharmacol; 1999 Nov; 58(10):1615-24. PubMed ID: 10535753
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
    Zhao R; Assaraf YG; Goldman ID
    J Biol Chem; 1998 Jul; 273(30):19065-71. PubMed ID: 9668089
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.
    Zhao R; Assaraf YG; Goldman ID
    J Biol Chem; 1998 Apr; 273(14):7873-9. PubMed ID: 9525881
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
    Zhao R; Seither R; Brigle KE; Sharina IG; Wang PJ; Goldman ID
    J Biol Chem; 1997 Aug; 272(34):21207-12. PubMed ID: 9261128
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function.
    Sierra EE; Goldman ID
    Biochem Pharmacol; 1998 May; 55(9):1505-12. PubMed ID: 10076544
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
    Zhao R; Gao F; Babani S; Goldman ID
    Clin Cancer Res; 2000 Aug; 6(8):3304-11. PubMed ID: 10955817
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells.
    Sierra EE; Brigle KE; Spinella MJ; Goldman ID
    Biochem Pharmacol; 1995 Oct; 50(8):1287-94. PubMed ID: 7488246
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
    Spinella MJ; Brigle KE; Sierra EE; Goldman ID
    J Biol Chem; 1995 Apr; 270(14):7842-9. PubMed ID: 7713875
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.
    Brigle KE; Spinella MJ; Sierra EE; Goldman ID
    J Biol Chem; 1995 Sep; 270(39):22974-9. PubMed ID: 7559435
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
    Zhao R; Gao F; Wang PJ; Goldman ID
    Mol Pharmacol; 2000 Feb; 57(2):317-23. PubMed ID: 10648641
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.
    Schuetz JD; Westin EH; Matherly LH; Pincus R; Swerdlow PS; Goldman ID
    J Biol Chem; 1989 Sep; 264(27):16261-7. PubMed ID: 2777791
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier.
    Sharina IG; Zhao R; Wang Y; Babani S; Goldman ID
    Mol Pharmacol; 2001 May; 59(5):1022-8. PubMed ID: 11306683
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier.
    Brigle KE; Seither RL; Westin EH; Goldman ID
    J Biol Chem; 1994 Feb; 269(6):4267-72. PubMed ID: 8307991
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
    Zhao R; Babani S; Gao F; Liu L; Goldman ID
    Clin Cancer Res; 2000 Sep; 6(9):3687-95. PubMed ID: 10999762
    [TBL] [Abstract][Full Text] [Related]  

  • 15. pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.
    Sierra EE; Brigle KE; Spinella MJ; Goldman ID
    Biochem Pharmacol; 1997 Jan; 53(2):223-31. PubMed ID: 9037255
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
    Drori S; Jansen G; Mauritz R; Peters GJ; Assaraf YG
    J Biol Chem; 2000 Oct; 275(40):30855-63. PubMed ID: 10899164
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
    Westerhof GR; Jansen G; van Emmerik N; Kathmann I; Rijksen G; Jackman AL; Schornagel JH
    Cancer Res; 1991 Oct; 51(20):5507-13. PubMed ID: 1655252
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
    Jansen G; Mauritz RM; Assaraf YG; Sprecher H; Drori S; Kathmann I; Westerhof GR; Priest DG; Bunni M; Pinedo HM; Schornagel JH; Peters GJ
    Adv Enzyme Regul; 1997; 37():59-76. PubMed ID: 9381986
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells.
    Roy K; Tolner B; Chiao JH; Sirotnak FM
    J Biol Chem; 1998 Jan; 273(5):2526-31. PubMed ID: 9446553
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects.
    Spinella MJ; Brigle KE; Freemantle SJ; Sierra EE; Goldman ID
    Biochem Pharmacol; 1996 Sep; 52(5):703-12. PubMed ID: 8765468
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.