BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

124 related articles for article (PubMed ID: 10557052)

  • 1. Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Chinnasamy N; Rafferty J; Lashford L; Chinnasamy D; Margison G; Thatcher N; Dexter T; Fairbairn L
    Leukemia; 1999 Nov; 13(11):1776-83. PubMed ID: 10557052
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.
    Chinnasamy N; Rafferty JA; Hickson I; Lashford LS; Longhurst SJ; Thatcher N; Margison GP; Dexter TM; Fairbairn LJ
    Gene Ther; 1998 Jun; 5(6):842-7. PubMed ID: 9747465
    [TBL] [Abstract][Full Text] [Related]  

  • 3. O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Westerhof GR; Down JD; Blokland I; Wood M; Boudewijn A; Watson AJ; McGown AT; Ploemacher RE; Margison GP
    Exp Hematol; 2001 May; 29(5):633-8. PubMed ID: 11376877
    [TBL] [Abstract][Full Text] [Related]  

  • 4. O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
    Chinnasamy N; Rafferty JA; Hickson I; Ashby J; Tinwell H; Margison GP; Dexter TM; Fairbairn LJ
    Blood; 1997 Mar; 89(5):1566-73. PubMed ID: 9057638
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
    Hickson I; Fairbairn LJ; Chinnasamy N; Lashford LS; Thatcher N; Margison GP; Dexter TM; Rafferty JA
    Gene Ther; 1998 Jun; 5(6):835-41. PubMed ID: 9747464
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells.
    Chinnasamy N; Fairbairn LJ; Laher J; Willington MA; Rafferty JA
    Mutat Res; 1998 Aug; 416(1-2):1-10. PubMed ID: 9725988
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide.
    Chinnasamy D; Fairbairn LJ; Neuenfeldt J; Treisman JS; Hanson JP; Margison GP; Chinnasamy N
    Hum Gene Ther; 2004 Aug; 15(8):758-69. PubMed ID: 15319033
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhancing hemopoietic drug resistance: a rationale for reconsidering the clinical use of mitozolomide.
    Fairbairn LJ; Chinnasamy N; Lashford LS; Chinnasamy D; Rafferty JA
    Cancer Gene Ther; 2000 Feb; 7(2):233-9. PubMed ID: 10770631
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM; Reese JS; Koç ON; Lee K; Schupp JE; Gerson SL
    Cancer Res; 1997 Nov; 57(22):5093-9. PubMed ID: 9371508
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.
    Hickson I; Fairbairn LJ; Chinnasamy N; Dexter TM; Margison GP; Rafferty JA
    Gene Ther; 1996 Oct; 3(10):868-77. PubMed ID: 8908500
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Gerson SL; Phillips W; Kastan M; Dumenco LL; Donovan C
    Blood; 1996 Sep; 88(5):1649-55. PubMed ID: 8781420
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS; Davis BM; Liu L; Gerson SL
    Clin Cancer Res; 1999 Jan; 5(1):163-9. PubMed ID: 9918215
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK; Harris LC; Venable CC; Brent TP
    Clin Cancer Res; 1997 Feb; 3(2):301-7. PubMed ID: 9815687
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
    Bibby MC; Thompson MJ; Rafferty JA; Margison GP; McElhinney RS
    Br J Cancer; 1999 Mar; 79(9-10):1332-9. PubMed ID: 10188873
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg AE; Williams DA
    Cancer Res; 2000 Sep; 60(18):5187-95. PubMed ID: 11016647
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Loktionova NA; Pegg AE
    Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Loktionova NA; Xu-Welliver M; Crone TM; Kanugula S; Pegg AE
    Biochem Pharmacol; 1999 Jul; 58(2):237-44. PubMed ID: 10423163
    [TBL] [Abstract][Full Text] [Related]  

  • 18. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Koç ON; Reese JS; Davis BM; Liu L; Majczenko KJ; Gerson SL
    Hum Gene Ther; 1999 Apr; 10(6):1021-30. PubMed ID: 10223735
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer.
    Koç ON; Reese JS; Szekely EM; Gerson SL
    Cancer Gene Ther; 1999; 6(4):340-8. PubMed ID: 10419052
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cai Y; Wu MH; Xu-Welliver M; Pegg AE; Ludeman SM; Dolan ME
    Cancer Res; 2000 Oct; 60(19):5464-9. PubMed ID: 11034089
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.