124 related articles for article (PubMed ID: 10574914)
1. Characteristics for a salt-bridge switch mutation of the alpha(1b) adrenergic receptor. Altered pharmacology and rescue of constitutive activity.
Porter JE; Perez DM
J Biol Chem; 1999 Dec; 274(49):34535-8. PubMed ID: 10574914
[TBL] [Abstract][Full Text] [Related]
2. Activation of the alpha1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint.
Porter JE; Hwa J; Perez DM
J Biol Chem; 1996 Nov; 271(45):28318-23. PubMed ID: 8910453
[TBL] [Abstract][Full Text] [Related]
3. Influence of a lysine 331 counterion on the pK(a) of aspartic acid 125: evidence for a salt-bridge interaction and role in alpha(1b)-adrenergic receptor activation.
Porter JE; Perez DM
J Pharmacol Exp Ther; 2000 Jan; 292(1):440-8. PubMed ID: 10604981
[TBL] [Abstract][Full Text] [Related]
4. The agonism and synergistic potentiation of weak partial agonists by triethylamine in alpha 1-adrenergic receptor activation: evidence for a salt bridge as the initiating process.
Porter JE; Edelmann SE; Waugh DJ; Piascik MT; Perez DM
Mol Pharmacol; 1998 Apr; 53(4):766-71. PubMed ID: 9547369
[TBL] [Abstract][Full Text] [Related]
5. Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.
Scheer A; Costa T; Fanelli F; De Benedetti PG; Mhaouty-Kodja S; Abuin L; Nenniger-Tosato M; Cotecchia S
Mol Pharmacol; 2000 Feb; 57(2):219-31. PubMed ID: 10648631
[TBL] [Abstract][Full Text] [Related]
6. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding.
Nagaoka Y; Ahmed M; Hossain M; Bhuiyan MA; Ishiguro M; Nakamura T; Watanabe M; Nagatomo T
J Pharmacol Sci; 2008 Jan; 106(1):114-20. PubMed ID: 18187928
[TBL] [Abstract][Full Text] [Related]
7. Dominant-negative activity of an alpha(1B)-adrenergic receptor signal-inactivating point mutation.
Chen S; Lin F; Xu M; Hwa J; Graham RM
EMBO J; 2000 Aug; 19(16):4265-71. PubMed ID: 10944109
[TBL] [Abstract][Full Text] [Related]
8. A constitutively active mutant of the alpha 1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G9 alpha and G11 alpha than the wild-type receptor.
Lee TW; Wise A; Cotecchia S; Milligan G
Biochem J; 1996 Nov; 320 ( Pt 1)(Pt 1):79-86. PubMed ID: 8947470
[TBL] [Abstract][Full Text] [Related]
9. Novel aromatic residues in transmembrane domains IV and V involved in agonist binding at alpha(1a)-adrenergic receptors.
Waugh DJ; Zhao MM; Zuscik MJ; Perez DM
J Biol Chem; 2000 Apr; 275(16):11698-705. PubMed ID: 10766790
[TBL] [Abstract][Full Text] [Related]
10. Synergism of constitutive activity in alpha 1-adrenergic receptor activation.
Hwa J; Gaivin R; Porter JE; Perez DM
Biochemistry; 1997 Jan; 36(3):633-9. PubMed ID: 9012678
[TBL] [Abstract][Full Text] [Related]
11. Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
Mhaouty-Kodja S; Barak LS; Scheer A; Abuin L; Diviani D; Caron MG; Cotecchia S
Mol Pharmacol; 1999 Feb; 55(2):339-47. PubMed ID: 9927627
[TBL] [Abstract][Full Text] [Related]
12. Constitutively active mutants of the alpha(1a)- and the alpha(1b)-adrenergic receptor subtypes reveal coupling to different signaling pathways and physiological responses in rat cardiac myocytes.
McWhinney C; Wenham D; Kanwal S; Kalman V; Hansen C; Robishaw JD
J Biol Chem; 2000 Jan; 275(3):2087-97. PubMed ID: 10636913
[TBL] [Abstract][Full Text] [Related]
13. Identification of critical extracellular loop residues involved in alpha 1-adrenergic receptor subtype-selective antagonist binding.
Zhao MM; Hwa J; Perez DM
Mol Pharmacol; 1996 Nov; 50(5):1118-26. PubMed ID: 8913343
[TBL] [Abstract][Full Text] [Related]
14. The unique nature of the serine interactions for alpha 1-adrenergic receptor agonist binding and activation.
Hwa J; Perez DM
J Biol Chem; 1996 Mar; 271(11):6322-7. PubMed ID: 8626427
[TBL] [Abstract][Full Text] [Related]
15. Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.
Scheer A; Fanelli F; Costa T; De Benedetti PG; Cotecchia S
EMBO J; 1996 Jul; 15(14):3566-78. PubMed ID: 8670860
[TBL] [Abstract][Full Text] [Related]
16. Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor.
Hannawacker A; Krasel C; Lohse MJ
Mol Pharmacol; 2002 Dec; 62(6):1431-7. PubMed ID: 12435811
[TBL] [Abstract][Full Text] [Related]
17. Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists.
Wang CD; Buck MA; Fraser CM
Mol Pharmacol; 1991 Aug; 40(2):168-79. PubMed ID: 1678850
[TBL] [Abstract][Full Text] [Related]
18. Inverse agonism and neutral antagonism at alpha(1a)- and alpha(1b)-adrenergic receptor subtypes.
Rossier O; Abuin L; Fanelli F; Leonardi A; Cotecchia S
Mol Pharmacol; 1999 Nov; 56(5):858-66. PubMed ID: 10531388
[TBL] [Abstract][Full Text] [Related]
19. Identification of critical determinants of alpha 1-adrenergic receptor subtype selective agonist binding.
Hwa J; Graham RM; Perez DM
J Biol Chem; 1995 Sep; 270(39):23189-95. PubMed ID: 7559466
[TBL] [Abstract][Full Text] [Related]
20. Computer simulations of signal transduction mechanism in alpha 1B-adrenergic and m3-muscarinic receptors.
Fanelli F; Menziani MC; De Benedetti PG
Protein Eng; 1995 Jun; 8(6):557-64. PubMed ID: 8532680
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]