BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

519 related articles for article (PubMed ID: 10582589)

  • 1. The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.
    Petanceska SS; Gandy S
    J Neurochem; 1999 Dec; 73(6):2316-20. PubMed ID: 10582589
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
    Parvathy S; Ehrlich M; Pedrini S; Diaz N; Refolo L; Buxbaum JD; Bogush A; Petanceska S; Gandy S
    J Neurochem; 2004 Aug; 90(4):1005-10. PubMed ID: 15287907
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
    J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
    Tomita S; Kirino Y; Suzuki T
    J Biol Chem; 1998 Mar; 273(11):6277-84. PubMed ID: 9497354
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.
    Zhang W; Espinoza D; Hines V; Innis M; Mehta P; Miller DL
    Biochim Biophys Acta; 1997 Nov; 1359(2):110-22. PubMed ID: 9409808
    [TBL] [Abstract][Full Text] [Related]  

  • 7. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
    Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effect of ionophores on the processing of the beta-amyloid precursor protein in different cell lines.
    Lahiri DK
    Cell Mol Neurobiol; 1994 Aug; 14(4):297-313. PubMed ID: 7788640
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease.
    Ling Y; Morgan K; Kalsheker N
    Int J Biochem Cell Biol; 2003 Nov; 35(11):1505-35. PubMed ID: 12824062
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM
    Biochemistry; 1999 Jul; 38(30):9728-34. PubMed ID: 10423252
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
    Skovronsky DM; Moore DB; Milla ME; Doms RW; Lee VM
    J Biol Chem; 2000 Jan; 275(4):2568-75. PubMed ID: 10644715
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 13. LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.
    Brodeur J; Thériault C; Lessard-Beaudoin M; Marcil A; Dahan S; Lavoie C
    Mol Neurodegener; 2012 Jun; 7():31. PubMed ID: 22734645
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein.
    Kojro E; Postina R; Buro C; Meiringer C; Gehrig-Burger K; Fahrenholz F
    FASEB J; 2006 Mar; 20(3):512-4. PubMed ID: 16401644
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
    Le Brocque D; Henry A; Cappai R; Li QX; Tanner JE; Galatis D; Gray C; Holmes S; Underwood JR; Beyreuther K; Masters CL; Evin G
    Biochemistry; 1998 Oct; 37(42):14958-65. PubMed ID: 9778373
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
    Peng Y; Lee DY; Jiang L; Ma Z; Schachter SC; Lemere CA
    Neuroscience; 2007 Dec; 150(2):386-95. PubMed ID: 17945434
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.