171 related articles for article (PubMed ID: 10601303)
1. Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.
Borngräber S; Browner M; Gillmor S; Gerth C; Anton M; Fletterick R; Kühn H
J Biol Chem; 1999 Dec; 274(52):37345-50. PubMed ID: 10601303
[TBL] [Abstract][Full Text] [Related]
2. Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis.
Walther M; Ivanov I; Myagkova G; Kuhn H
Chem Biol; 2001 Aug; 8(8):779-90. PubMed ID: 11514227
[TBL] [Abstract][Full Text] [Related]
3. Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.
Schwarz K; Walther M; Anton M; Gerth C; Feussner I; Kuhn H
J Biol Chem; 2001 Jan; 276(1):773-9. PubMed ID: 11027682
[TBL] [Abstract][Full Text] [Related]
4. Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation.
Schwarz K; Borngräber S; Anton M; Kuhn H
Biochemistry; 1998 Nov; 37(44):15327-35. PubMed ID: 9799493
[TBL] [Abstract][Full Text] [Related]
5. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.
Jisaka M; Kim RB; Boeglin WE; Brash AR
J Biol Chem; 2000 Jan; 275(2):1287-93. PubMed ID: 10625675
[TBL] [Abstract][Full Text] [Related]
6. Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases.
Borngräber S; Kuban RJ; Anton M; Kühn H
J Mol Biol; 1996 Dec; 264(5):1145-53. PubMed ID: 9000636
[TBL] [Abstract][Full Text] [Related]
7. Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.
Sloane DL; Leung R; Barnett J; Craik CS; Sigal E
Protein Eng; 1995 Mar; 8(3):275-82. PubMed ID: 7479689
[TBL] [Abstract][Full Text] [Related]
8. Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis.
Gan QF; Browner MF; Sloane DL; Sigal E
J Biol Chem; 1996 Oct; 271(41):25412-8. PubMed ID: 8810309
[TBL] [Abstract][Full Text] [Related]
9. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis.
Meruvu S; Walther M; Ivanov I; Hammarström S; Fürstenberger G; Krieg P; Reddanna P; Kuhn H
J Biol Chem; 2005 Nov; 280(44):36633-41. PubMed ID: 16129665
[TBL] [Abstract][Full Text] [Related]
10. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
Gillmor SA; Villaseñor A; Fletterick R; Sigal E; Browner MF
Nat Struct Biol; 1997 Dec; 4(12):1003-9. PubMed ID: 9406550
[TBL] [Abstract][Full Text] [Related]
11. Alterations in leukotriene synthase activity of the human 5-lipoxygenase by site-directed mutagenesis affecting its positional specificity.
Schwarz K; Gerth C; Anton M; Kuhn H
Biochemistry; 2000 Nov; 39(47):14515-21. PubMed ID: 11087405
[TBL] [Abstract][Full Text] [Related]
12. A primary determinant for lipoxygenase positional specificity.
Sloane DL; Leung R; Craik CS; Sigal E
Nature; 1991 Nov; 354(6349):149-52. PubMed ID: 1944593
[TBL] [Abstract][Full Text] [Related]
13. Affinity labeling of the rabbit 12/15-lipoxygenase using azido derivatives of arachidonic acid.
Romanov S; Wiesner R; Myagkova G; Kuhn H; Ivanov I
Biochemistry; 2006 Mar; 45(11):3554-62. PubMed ID: 16533037
[TBL] [Abstract][Full Text] [Related]
14. Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site.
Ivanov I; Schwarz K; Holzhütter HG; Myagkova G; Kühn H
Biochem J; 1998 Dec; 336 ( Pt 2)(Pt 2):345-52. PubMed ID: 9820810
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for the positional specificity of lipoxygenases.
Kuhn H
Prostaglandins Other Lipid Mediat; 2000 Aug; 62(3):255-70. PubMed ID: 10963793
[TBL] [Abstract][Full Text] [Related]
16. The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.
Walther M; Anton M; Wiedmann M; Fletterick R; Kuhn H
J Biol Chem; 2002 Jul; 277(30):27360-6. PubMed ID: 12004065
[TBL] [Abstract][Full Text] [Related]
17. Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms.
Walther M; Roffeis J; Jansen C; Anton M; Ivanov I; Kuhn H
Biochim Biophys Acta; 2009 Aug; 1791(8):827-35. PubMed ID: 19481615
[TBL] [Abstract][Full Text] [Related]
18. Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium.
Walther M; Wiesner R; Kuhn H
J Biol Chem; 2004 Jan; 279(5):3717-25. PubMed ID: 14594811
[TBL] [Abstract][Full Text] [Related]
19. Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity.
Sigal E; Sloane DL; Conrad DJ
J Lipid Mediat; 1993; 6(1-3):75-88. PubMed ID: 8358018
[TBL] [Abstract][Full Text] [Related]
20. Probing a novel potato lipoxygenase with dual positional specificity reveals primary determinants of substrate binding and requirements for a surface hydrophobic loop and has implications for the role of lipoxygenases in tubers.
Hughes RK; West SI; Hornostaj AR; Lawson DM; Fairhurst SA; Sanchez RO; Hough P; Robinson BH; Casey R
Biochem J; 2001 Jan; 353(Pt 2):345-55. PubMed ID: 11139400
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]