These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 10617083)

  • 1. Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
    Hay MP; Wilson WR; Denny WA
    Bioorg Med Chem Lett; 1999 Dec; 9(24):3417-22. PubMed ID: 10617083
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nitroreductase-based GDEPT.
    Denny WA
    Curr Pharm Des; 2002; 8(15):1349-61. PubMed ID: 12052212
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapy.
    Asche C; Dumy P; Carrez D; Croisy A; Demeunynck M
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1990-4. PubMed ID: 16442795
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
    Hay MP; Atwell GJ; Wilson WR; Pullen SM; Denny WA
    J Med Chem; 2003 Jun; 46(12):2456-66. PubMed ID: 12773049
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP; Anderson RF; Ferry DM; Wilson WR; Denny WA
    J Med Chem; 2003 Dec; 46(25):5533-45. PubMed ID: 14640560
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy.
    Hay MP; Wilson WR; Denny WA
    Bioorg Med Chem; 2005 Jun; 13(12):4043-55. PubMed ID: 15911317
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
    Jiang Y; Han J; Yu C; Vass SO; Searle PF; Browne P; Knox RJ; Hu L
    J Med Chem; 2006 Jul; 49(14):4333-43. PubMed ID: 16821793
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
    Atwell GJ; Yang S; Pruijn FB; Pullen SM; Hogg A; Patterson AV; Wilson WR; Denny WA
    J Med Chem; 2007 Mar; 50(6):1197-212. PubMed ID: 17326614
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals.
    Bhaumik S; Sekar TV; Depuy J; Klimash J; Paulmurugan R
    Gene Ther; 2012 Mar; 19(3):295-302. PubMed ID: 21753794
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
    Weedon SJ; Green NK; McNeish IA; Gilligan MG; Mautner V; Wrighton CJ; Mountain A; Young LS; Kerr DJ; Searle PF
    Int J Cancer; 2000 Jun; 86(6):848-54. PubMed ID: 10842200
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nitroreductase-activated nitric oxide (NO) prodrugs.
    Sharma K; Sengupta K; Chakrapani H
    Bioorg Med Chem Lett; 2013 Nov; 23(21):5964-7. PubMed ID: 24050886
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite.
    Bridgewater JA; Knox RJ; Pitts JD; Collins MK; Springer CJ
    Hum Gene Ther; 1997 Apr; 8(6):709-17. PubMed ID: 9113510
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Repurposing
    Ruiz de Garibay G; García de Jalón E; Stigen E; Lund KB; Popa M; Davidson B; Safont MM; Rygh CB; Espedal H; Barrett TM; Haug BE; McCormack E
    Theranostics; 2021; 11(12):6044-6057. PubMed ID: 33897898
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.
    Green NK; Youngs DJ; Neoptolemos JP; Friedlos F; Knox RJ; Springer CJ; Anlezark GM; Michael NP; Melton RG; Ford MJ; Young LS; Kerr DJ; Searle PF
    Cancer Gene Ther; 1997; 4(4):229-38. PubMed ID: 9253508
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
    Tokay E; Güngör T; Hacıoğlu N; Önder FC; Gülhan ÜG; Tok TT; Çelik A; Ay M; Köçkar F
    Eur J Med Chem; 2020 Feb; 187():111937. PubMed ID: 31841727
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
    Bailey SM; Knox RJ; Hobbs SM; Jenkins TC; Mauger AB; Melton RG; Burke PJ; Connors TA; Hart IR
    Gene Ther; 1996 Dec; 3(12):1143-50. PubMed ID: 8986441
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation.
    Güngör T; Tokay E; Güven Gülhan Ü; Hacıoğlu N; Çelik A; Köçkar F; Ay M
    Bioorg Chem; 2020 Dec; 105():104450. PubMed ID: 33189994
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
    Helsby NA; Atwell GJ; Yang S; Palmer BD; Anderson RF; Pullen SM; Ferry DM; Hogg A; Wilson WR; Denny WA
    J Med Chem; 2004 Jun; 47(12):3295-307. PubMed ID: 15163209
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.
    McNeish IA; Green NK; Gilligan MG; Ford MJ; Mautner V; Young LS; Kerr DJ; Searle PF
    Gene Ther; 1998 Aug; 5(8):1061-9. PubMed ID: 10326029
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
    Wilson WR; Pullen SM; Hogg A; Helsby NA; Hicks KO; Denny WA
    Cancer Res; 2002 Mar; 62(5):1425-32. PubMed ID: 11888915
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.