These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

246 related articles for article (PubMed ID: 10618433)

  • 1. Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.
    Harth G; Zamecnik PC; Tang JY; Tabatadze D; Horwitz MA
    Proc Natl Acad Sci U S A; 2000 Jan; 97(1):418-23. PubMed ID: 10618433
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology.
    Harth G; Horwitz MA; Tabatadze D; Zamecnik PC
    Proc Natl Acad Sci U S A; 2002 Nov; 99(24):15614-9. PubMed ID: 12427974
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets.
    Harth G; Horwitz MA
    J Exp Med; 1999 May; 189(9):1425-36. PubMed ID: 10224282
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Poly-L-glutamate/glutamine synthesis in the cell wall of Mycobacterium bovis is regulated in response to nitrogen availability.
    Tripathi D; Chandra H; Bhatnagar R
    BMC Microbiol; 2013 Oct; 13():226. PubMed ID: 24112767
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inositol-1-phosphate synthetase mRNA as a new target for antisense inhibition of Mycobacterium tuberculosis.
    Li Y; Chen Z; Li X; Zhang H; Huang Q; Zhang Y; Xu S
    J Biotechnol; 2007 Mar; 128(4):726-34. PubMed ID: 17275118
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis.
    Harth G; Zamecnik PC; Tabatadze D; Pierson K; Horwitz MA
    Proc Natl Acad Sci U S A; 2007 Apr; 104(17):7199-204. PubMed ID: 17438292
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression and efficient export of enzymatically active Mycobacterium tuberculosis glutamine synthetase in Mycobacterium smegmatis and evidence that the information for export is contained within the protein.
    Harth G; Horwitz MA
    J Biol Chem; 1997 Sep; 272(36):22728-35. PubMed ID: 9278431
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Low expression level of glnA1 accounts for absence of cell wall associated poly-l-glutamate/glutamine in Mycobacterium smegmatis.
    Tripathi D; Kant S; Garg R; Bhatnagar R
    Biochem Biophys Res Commun; 2015 Mar; 458(2):240-5. PubMed ID: 25637529
    [TBL] [Abstract][Full Text] [Related]  

  • 9. All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
    Harth G; Maslesa-Galić S; Tullius MV; Horwitz MA
    Mol Microbiol; 2005 Nov; 58(4):1157-72. PubMed ID: 16262797
    [TBL] [Abstract][Full Text] [Related]  

  • 10. High extracellular levels of Mycobacterium tuberculosis glutamine synthetase and superoxide dismutase in actively growing cultures are due to high expression and extracellular stability rather than to a protein-specific export mechanism.
    Tullius MV; Harth G; Horwitz MA
    Infect Immun; 2001 Oct; 69(10):6348-63. PubMed ID: 11553579
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.
    Harth G; Horwitz MA
    Infect Immun; 2003 Jan; 71(1):456-64. PubMed ID: 12496196
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform.
    Theron A; Roth RL; Hoppe H; Parkinson C; van der Westhuyzen CW; Stoychev S; Wiid I; Pietersen RD; Baker B; Kenyon CP
    PLoS One; 2017; 12(10):e0185068. PubMed ID: 28972974
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.
    Odell LR; Nilsson MT; Gising J; Lagerlund O; Muthas D; Nordqvist A; Karlén A; Larhed M
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4790-3. PubMed ID: 19560924
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Computational Sampling and Simulation Based Assessment of Novel Mycobacterium tuberculosis Glutamine Synthetase Inhibitors: Study Involving Structure Based Drug Design and Free Energy Perturbation.
    Suryadevara P; Yogeeswari P; Soni V; Devi PB; Nandicoori VK; Sriram D
    Curr Top Med Chem; 2016; 16(9):978-95. PubMed ID: 26303425
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase.
    Kosikowska P; Bochno M; Macegoniuk K; Forlani G; Kafarski P; Berlicki Ł
    J Enzyme Inhib Med Chem; 2016 Dec; 31(6):931-8. PubMed ID: 26235917
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glutamine synthetase encoded by glnA-1 is necessary for cell wall resistance and pathogenicity of Mycobacterium bovis.
    Chandra H; Basir SF; Gupta M; Banerjee N
    Microbiology (Reading); 2010 Dec; 156(Pt 12):3669-3677. PubMed ID: 20724386
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
    Couturier C; Silve S; Morales R; Pessegue B; Llopart S; Nair A; Bauer A; Scheiper B; Pöverlein C; Ganzhorn A; Lagrange S; Bacqué E
    Bioorg Med Chem Lett; 2015 Apr; 25(7):1455-9. PubMed ID: 25770781
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ethambutol targets the glutamate racemase of Mycobacterium tuberculosis-an enzyme involved in peptidoglycan biosynthesis.
    Pawar A; Jha P; Konwar C; Chaudhry U; Chopra M; Saluja D
    Appl Microbiol Biotechnol; 2019 Jan; 103(2):843-851. PubMed ID: 30456576
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity.
    Harth G; Clemens DL; Horwitz MA
    Proc Natl Acad Sci U S A; 1994 Sep; 91(20):9342-6. PubMed ID: 7937767
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model.
    Lee S; Jeon BY; Bardarov S; Chen M; Morris SL; Jacobs WR
    Infect Immun; 2006 Nov; 74(11):6491-5. PubMed ID: 17057098
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.