348 related articles for article (PubMed ID: 10623730)
1. Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
Gustafson EA; Schinazi RF; Fingeroth JD
J Virol; 2000 Jan; 74(2):684-92. PubMed ID: 10623730
[TBL] [Abstract][Full Text] [Related]
2. The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
Gustafson EA; Chillemi AC; Sage DR; Fingeroth JD
Antimicrob Agents Chemother; 1998 Nov; 42(11):2923-31. PubMed ID: 9797227
[TBL] [Abstract][Full Text] [Related]
3. Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir.
Cannon JS; Hamzeh F; Moore S; Nicholas J; Ambinder RF
J Virol; 1999 Jun; 73(6):4786-93. PubMed ID: 10233939
[TBL] [Abstract][Full Text] [Related]
4. Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Degrève B; Esnouf R; De Clercq E; Balzarini J
Mol Pharmacol; 2000 Dec; 58(6):1326-32. PubMed ID: 11093770
[TBL] [Abstract][Full Text] [Related]
5. The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.
Balzarini J; Liekens S; Esnouf R; De Clercq E
Biochemistry; 2002 May; 41(20):6517-24. PubMed ID: 12009916
[TBL] [Abstract][Full Text] [Related]
6. Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Degrève B; Esnouf R; De Clercq E; Balzarini J
Mol Pharmacol; 2001 Feb; 59(2):285-93. PubMed ID: 11160865
[TBL] [Abstract][Full Text] [Related]
7. The bystander effect mediated by the new murine gammaherpesvirus 72--thymidine kinase/5'-fluoro-2'-deoxyuridine (MHV72-TK/5-FUdR) system in vitro.
Raslova H; Matis J; Rezuchova I; Macakova K; Berebbi M; Kudelova M
Antivir Chem Chemother; 2000 Jul; 11(4):273-82. PubMed ID: 10950389
[TBL] [Abstract][Full Text] [Related]
8. Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
Kokoris MS; Black ME
Protein Sci; 2002 Sep; 11(9):2267-72. PubMed ID: 12192082
[TBL] [Abstract][Full Text] [Related]
9. The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.
Meng Q; Hagemeier SR; Fingeroth JD; Gershburg E; Pagano JS; Kenney SC
J Virol; 2010 May; 84(9):4534-42. PubMed ID: 20181711
[TBL] [Abstract][Full Text] [Related]
10. Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
Mercer KE; Ahn CE; Coke A; Compadre CM; Drake RR
Protein Eng; 2002 Nov; 15(11):903-11. PubMed ID: 12538910
[TBL] [Abstract][Full Text] [Related]
11. Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase.
Hussein IT; Miguel RN; Tiley LS; Field HJ
Arch Virol; 2008; 153(3):495-505. PubMed ID: 18196203
[TBL] [Abstract][Full Text] [Related]
12. A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
Salomon B; Maury S; Loubière L; Caruso M; Onclercq R; Klatzmann D
Mol Cell Biol; 1995 Oct; 15(10):5322-8. PubMed ID: 7565681
[TBL] [Abstract][Full Text] [Related]
13. VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death.
Liu CS; Kong B; Xia HH; Ellem KA; Wei MQ
J Gene Med; 2001; 3(2):145-52. PubMed ID: 11318113
[TBL] [Abstract][Full Text] [Related]
14. Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
Drake RR; McMasters R; Krisa S; Hume SD; Rechtin TM; Saylors RL; Chiang Y; Govindarajan R; Munshi NC
Antiviral Res; 1997 Aug; 35(3):177-85. PubMed ID: 9298757
[TBL] [Abstract][Full Text] [Related]
15. Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
Hinds TA; Compadre C; Hurlburt BK; Drake RR
Biochemistry; 2000 Apr; 39(14):4105-11. PubMed ID: 10747801
[TBL] [Abstract][Full Text] [Related]
16. Ethanol decreases the efficiency of phosphorylation of thymidine kinase in a human T-lymphocytic cell line.
Prakash O; Tang ZY; Zhou P; Peng X; Kolls J; Shellito JE; Nelson S
Alcohol Clin Exp Res; 2002 Mar; 26(3):295-302. PubMed ID: 11923581
[TBL] [Abstract][Full Text] [Related]
17. Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1.
Bae PK; Kim JH; Kim HS; Chung IK; Paik SG; Lee CK
Antiviral Res; 2006 Jul; 70(3):93-104. PubMed ID: 16546268
[TBL] [Abstract][Full Text] [Related]
18. Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Sienaert R; Naesens L; Brancale A; De Clercq E; McGuigan C; Balzarini J
Mol Pharmacol; 2002 Feb; 61(2):249-54. PubMed ID: 11809847
[TBL] [Abstract][Full Text] [Related]
19. The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
Wang L; Sun R; Eriksson S
Antimicrob Agents Chemother; 2011 Jun; 55(6):2552-8. PubMed ID: 21444706
[TBL] [Abstract][Full Text] [Related]
20. Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.
Maga G; Focher F; Wright GE; Capobianco M; Garbesi A; Bendiscioli A; Spadari S
Biochem J; 1994 Aug; 302 ( Pt 1)(Pt 1):279-82. PubMed ID: 8068016
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]