301 related articles for article (PubMed ID: 10636839)
1. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
Octave JN; Essalmani R; Tasiaux B; Menager J; Czech C; Mercken L
J Biol Chem; 2000 Jan; 275(3):1525-8. PubMed ID: 10636839
[TBL] [Abstract][Full Text] [Related]
2. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
Pitsi D; Kienlen-Campard P; Octave JN
J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
[TBL] [Abstract][Full Text] [Related]
3. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Xia W
Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
[TBL] [Abstract][Full Text] [Related]
4. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Pitsi D; Octave JN
J Biol Chem; 2004 Jun; 279(24):25333-8. PubMed ID: 15087467
[TBL] [Abstract][Full Text] [Related]
5. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
6. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
7. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
[TBL] [Abstract][Full Text] [Related]
8. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
9. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
10. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
[TBL] [Abstract][Full Text] [Related]
11. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
LleĆ³ A; Berezovska O; Ramdya P; Fukumoto H; Raju S; Shah T; Hyman BT
J Biol Chem; 2003 Nov; 278(48):47370-5. PubMed ID: 12960155
[TBL] [Abstract][Full Text] [Related]
12. Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.
Verdile G; Martins RN; Duthie M; Holmes E; St George-Hyslop PH; Fraser PE
J Biol Chem; 2000 Jul; 275(27):20794-8. PubMed ID: 10801777
[TBL] [Abstract][Full Text] [Related]
13. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
14. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
[TBL] [Abstract][Full Text] [Related]
15. Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.
Sernee MF; Evin G; Culvenor JG; Villadangos JA; Beyreuther K; Masters CL; Cappai R
Eur J Biochem; 2003 Feb; 270(3):495-506. PubMed ID: 12542699
[TBL] [Abstract][Full Text] [Related]
16. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Rozmahel R; Mount HT; Chen F; Nguyen V; Huang J; Erdebil S; Liauw J; Yu G; Hasegawa H; Gu Y; Song YQ; Schmidt SD; Nixon RA; Mathews PM; Bergeron C; Fraser P; Westaway D; St George-Hyslop P
Proc Natl Acad Sci U S A; 2002 Oct; 99(22):14452-7. PubMed ID: 12388777
[TBL] [Abstract][Full Text] [Related]
17. Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells.
Kametani F; Tanaka K; Usami M; Maruyama K; Mori H
J Neurol Sci; 2001 Jul; 188(1-2):27-31. PubMed ID: 11489281
[TBL] [Abstract][Full Text] [Related]
18. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
19. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
J Biol Chem; 2000 Nov; 275(47):36794-802. PubMed ID: 10962005
[TBL] [Abstract][Full Text] [Related]
20. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; Ramabhadran TV; Kwok JB; Schofield PR; Carter T; Gandy S; Martins RN
Mol Psychiatry; 2004 Jun; 9(6):594-602. PubMed ID: 14993906
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]