BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

318 related articles for article (PubMed ID: 10642173)

  • 1. Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.
    Briggs SD; Lerner EC; Smithgall TE
    Biochemistry; 2000 Jan; 39(3):489-95. PubMed ID: 10642173
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.
    Lerner EC; Smithgall TE
    Nat Struct Biol; 2002 May; 9(5):365-9. PubMed ID: 11976726
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.
    Dutartre H; Harris M; Olive D; Collette Y
    Virology; 1998 Aug; 247(2):200-11. PubMed ID: 9705913
    [TBL] [Abstract][Full Text] [Related]  

  • 4. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.
    Briggs SD; Sharkey M; Stevenson M; Smithgall TE
    J Biol Chem; 1997 Jul; 272(29):17899-902. PubMed ID: 9218412
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement.
    Moarefi I; LaFevre-Bernt M; Sicheri F; Huse M; Lee CH; Kuriyan J; Miller WT
    Nature; 1997 Feb; 385(6617):650-3. PubMed ID: 9024665
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.
    Trible RP; Emert-Sedlak L; Smithgall TE
    J Biol Chem; 2006 Sep; 281(37):27029-38. PubMed ID: 16849330
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck.
    Ye H; Choi HJ; Poe J; Smithgall TE
    Biochemistry; 2004 Dec; 43(50):15775-84. PubMed ID: 15595833
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.
    Choi HJ; Smithgall TE
    J Mol Biol; 2004 Nov; 343(5):1255-68. PubMed ID: 15491611
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.
    Greenway AL; Dutartre H; Allen K; McPhee DA; Olive D; Collette Y
    J Virol; 1999 Jul; 73(7):6152-8. PubMed ID: 10364375
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck.
    Murakami Y; Fukazawa H; Kobatake T; Yamagoe S; Takebe Y; Tobiume M; Matsuda M; Uehara Y
    Antiviral Res; 2002 Jul; 55(1):161-8. PubMed ID: 12076760
    [TBL] [Abstract][Full Text] [Related]  

  • 11. RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.
    Arold S; O'Brien R; Franken P; Strub MP; Hoh F; Dumas C; Ladbury JE
    Biochemistry; 1998 Oct; 37(42):14683-91. PubMed ID: 9778343
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.
    Briggs SD; Smithgall TE
    J Biol Chem; 1999 Sep; 274(37):26579-83. PubMed ID: 10473622
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation.
    Chang AH; O'Shaughnessy MV; Jirik FR
    Eur J Immunol; 2001 Aug; 31(8):2382-7. PubMed ID: 11500821
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.
    Lee CH; Leung B; Lemmon MA; Zheng J; Cowburn D; Kuriyan J; Saksela K
    EMBO J; 1995 Oct; 14(20):5006-15. PubMed ID: 7588629
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.
    Schreiner SJ; Schiavone AP; Smithgall TE
    J Biol Chem; 2002 Nov; 277(47):45680-7. PubMed ID: 12244095
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
    Alvarado JJ; Tarafdar S; Yeh JI; Smithgall TE
    J Biol Chem; 2014 Oct; 289(41):28539-53. PubMed ID: 25122770
    [TBL] [Abstract][Full Text] [Related]  

  • 17. SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef.
    Hiipakka M; Poikonen K; Saksela K
    J Mol Biol; 1999 Nov; 293(5):1097-106. PubMed ID: 10547288
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes.
    Cheng H; Hoxie JP; Parks WP
    Virology; 1999 Nov; 264(1):5-15. PubMed ID: 10544125
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.
    Saksela K; Cheng G; Baltimore D
    EMBO J; 1995 Feb; 14(3):484-91. PubMed ID: 7859737
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
    Arold S; Franken P; Strub MP; Hoh F; Benichou S; Benarous R; Dumas C
    Structure; 1997 Oct; 5(10):1361-72. PubMed ID: 9351809
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.