BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 10644712)

  • 1. Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding.
    Cosme J; Johnson EF
    J Biol Chem; 2000 Jan; 275(4):2545-53. PubMed ID: 10644712
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modification of its N-terminus.
    von Wachenfeldt C; Richardson TH; Cosme J; Johnson EF
    Arch Biochem Biophys; 1997 Mar; 339(1):107-14. PubMed ID: 9056240
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The structure of microsomal cytochrome P450 2C5: a steroid and drug metabolizing enzyme.
    Johnson EF; Wester MR; Stout CD
    Endocr Res; 2002 Nov; 28(4):435-41. PubMed ID: 12530646
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.
    Wester MR; Johnson EF; Marques-Soares C; Dijols S; Dansette PM; Mansuy D; Stout CD
    Biochemistry; 2003 Aug; 42(31):9335-45. PubMed ID: 12899620
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features.
    Williams PA; Cosme J; Sridhar V; Johnson EF; McRee DE
    J Inorg Biochem; 2000 Aug; 81(3):183-90. PubMed ID: 11051563
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5.
    Wester MR; Stout CD; Johnson EF
    Methods Enzymol; 2002; 357():73-9. PubMed ID: 12424899
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH; Johnson EF
    J Biol Chem; 1994 Sep; 269(39):23937-43. PubMed ID: 7929041
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation.
    Kim D; Guengerich FP
    Biochemistry; 2004 Feb; 43(4):981-8. PubMed ID: 14744142
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Subcellular localization, aggregation state, and catalytic activity of microsomal P450 cytochromes modified in the NH2-terminal region and expressed in Escherichia coli.
    Pernecky SJ; Olken NM; Bestervelt LL; Coon MJ
    Arch Biochem Biophys; 1995 Apr; 318(2):446-56. PubMed ID: 7733676
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.
    Hsu MH; Griffin KJ; Wang Y; Kemper B; Johnson EF
    J Biol Chem; 1993 Apr; 268(10):6939-44. PubMed ID: 8463225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation.
    Straub P; Lloyd M; Johnson EF; Kemper B
    Biochemistry; 1994 Jul; 33(26):8029-34. PubMed ID: 8025107
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.
    Ramarao M; Kemper B
    Mol Pharmacol; 1995 Sep; 48(3):417-24. PubMed ID: 7565621
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1.
    Murtazina D; Puchkaev AV; Schein CH; Oezguen N; Braun W; Nanavati A; Pikuleva IA
    J Biol Chem; 2002 Oct; 277(40):37582-9. PubMed ID: 12124390
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL; John GH; Harlow GR; Halpert JR
    Drug Metab Dispos; 1995 Jul; 23(7):702-7. PubMed ID: 7587957
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.
    Williams PA; Cosme J; Sridhar V; Johnson EF; McRee DE
    Mol Cell; 2000 Jan; 5(1):121-31. PubMed ID: 10678174
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for communality in the primary determinants of CYP74 catalysis and of structural similarities between CYP74 and classical mammalian P450 enzymes.
    Hughes RK; Yousafzai FK; Ashton R; Chechetkin IR; Fairhurst SA; Hamberg M; Casey R
    Proteins; 2008 Sep; 72(4):1199-211. PubMed ID: 18338380
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Substitutions in the C-terminal portion of the catalytic domain partially reverse assembly defects introduced by mutations in the N-terminal linker sequence of cytochrome P450 2C2.
    Doray B; Chen CD; Kemper B
    Biochemistry; 1999 Sep; 38(37):12180-6. PubMed ID: 10508423
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
    Pallan PS; Wang C; Lei L; Yoshimoto FK; Auchus RJ; Waterman MR; Guengerich FP; Egli M
    J Biol Chem; 2015 May; 290(21):13128-43. PubMed ID: 25855791
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.
    Pikuleva IA; Puchkaev A; Björkhem I
    Biochemistry; 2001 Jun; 40(25):7621-9. PubMed ID: 11412116
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.
    Richardson TH; Hsu MH; Kronbach T; Barnes HJ; Chan G; Waterman MR; Kemper B; Johnson EF
    Arch Biochem Biophys; 1993 Jan; 300(1):510-6. PubMed ID: 8380971
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.