714 related articles for article (PubMed ID: 10649997)
1. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
Hazuda DJ; Felock P; Witmer M; Wolfe A; Stillmock K; Grobler JA; Espeseth A; Gabryelski L; Schleif W; Blau C; Miller MD
Science; 2000 Jan; 287(5453):646-50. PubMed ID: 10649997
[TBL] [Abstract][Full Text] [Related]
2. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Fikkert V; Van Maele B; Vercammen J; Hantson A; Van Remoortel B; Michiels M; Gurnari C; Pannecouque C; De Maeyer M; Engelborghs Y; De Clercq E; Debyser Z; Witvrouw M
J Virol; 2003 Nov; 77(21):11459-70. PubMed ID: 14557631
[TBL] [Abstract][Full Text] [Related]
3. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Espeseth AS; Felock P; Wolfe A; Witmer M; Grobler J; Anthony N; Egbertson M; Melamed JY; Young S; Hamill T; Cole JL; Hazuda DJ
Proc Natl Acad Sci U S A; 2000 Oct; 97(21):11244-9. PubMed ID: 11016953
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
Reinke R; Lee DJ; Robinson WE
Antimicrob Agents Chemother; 2002 Oct; 46(10):3301-3. PubMed ID: 12234866
[TBL] [Abstract][Full Text] [Related]
5. Human immunodeficiency virus type-1 integrase containing a glycine to serine mutation at position 140 is attenuated for catalysis and resistant to integrase inhibitors.
King PJ; Lee DJ; Reinke RA; Victoria JG; Beale K; Robinson WE
Virology; 2003 Feb; 306(1):147-61. PubMed ID: 12620807
[TBL] [Abstract][Full Text] [Related]
6. Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Svarovskaia ES; Barr R; Zhang X; Pais GC; Marchand C; Pommier Y; Burke TR; Pathak VK
J Virol; 2004 Apr; 78(7):3210-22. PubMed ID: 15016842
[TBL] [Abstract][Full Text] [Related]
7. The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP; Johns BA; Gartland MJ; Foster SA; Miller WH; Ferris RG; Hazen RJ; Underwood MR; Boros EE; Thompson JB; Weatherhead JG; Koble CS; Allen SH; Schaller LT; Sherrill RG; Yoshinaga T; Kobayashi M; Wakasa-Morimoto C; Miki S; Nakahara K; Noshi T; Sato A; Fujiwara T
Antimicrob Agents Chemother; 2008 Mar; 52(3):901-8. PubMed ID: 18160521
[TBL] [Abstract][Full Text] [Related]
8. Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
Kehlenbeck S; Betz U; Birkmann A; Fast B; Göller AH; Henninger K; Lowinger T; Marrero D; Paessens A; Paulsen D; Pevzner V; Schohe-Loop R; Tsujishita H; Welker R; Kreuter J; Rübsamen-Waigmann H; Dittmer F
J Virol; 2006 Jul; 80(14):6883-94. PubMed ID: 16809294
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Pluymers W; Pais G; Van Maele B; Pannecouque C; Fikkert V; Burke TR; De Clercq E; Witvrouw M; Neamati N; Debyser Z
Antimicrob Agents Chemother; 2002 Oct; 46(10):3292-7. PubMed ID: 12234864
[TBL] [Abstract][Full Text] [Related]
10. Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance.
Zahm JA; Bera S; Pandey KK; Vora A; Stillmock K; Hazuda D; Grandgenett DP
Antimicrob Agents Chemother; 2008 Sep; 52(9):3358-68. PubMed ID: 18591263
[TBL] [Abstract][Full Text] [Related]
11. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Hazuda DJ; Anthony NJ; Gomez RP; Jolly SM; Wai JS; Zhuang L; Fisher TE; Embrey M; Guare JP; Egbertson MS; Vacca JP; Huff JR; Felock PJ; Witmer MV; Stillmock KA; Danovich R; Grobler J; Miller MD; Espeseth AS; Jin L; Chen IW; Lin JH; Kassahun K; Ellis JD; Wong BK; Xu W; Pearson PG; Schleif WA; Cortese R; Emini E; Summa V; Holloway MK; Young SD
Proc Natl Acad Sci U S A; 2004 Aug; 101(31):11233-8. PubMed ID: 15277684
[TBL] [Abstract][Full Text] [Related]
12. Fully flexible low-mode docking: application to induced fit in HIV integrase.
Keserû GM; Kolossváry I
J Am Chem Soc; 2001 Dec; 123(50):12708-9. PubMed ID: 11741448
[No Abstract] [Full Text] [Related]
13. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase.
Robinson WE; Cordeiro M; Abdel-Malek S; Jia Q; Chow SA; Reinecke MG; Mitchell WM
Mol Pharmacol; 1996 Oct; 50(4):846-55. PubMed ID: 8863829
[TBL] [Abstract][Full Text] [Related]
14. New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.
Corona A; di Leva FS; Rigogliuso G; Pescatori L; Madia VN; Subra F; Delelis O; Esposito F; Cadeddu M; Costi R; Cosconati S; Novellino E; di Santo R; Tramontano E
Antiviral Res; 2016 Oct; 134():236-243. PubMed ID: 27659398
[TBL] [Abstract][Full Text] [Related]
15. Structure-activity relationships of HIV-1 integrase inhibitors--enzyme-ligand interactions.
Maurin C; Bailly F; Cotelle P
Curr Med Chem; 2003 Sep; 10(18):1795-810. PubMed ID: 12871105
[TBL] [Abstract][Full Text] [Related]
16. Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
Balakrishnan M; Yant SR; Tsai L; O'Sullivan C; Bam RA; Tsai A; Niedziela-Majka A; Stray KM; Sakowicz R; Cihlar T
PLoS One; 2013; 8(9):e74163. PubMed ID: 24040198
[TBL] [Abstract][Full Text] [Related]
17. In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Kobayashi M; Yoshinaga T; Seki T; Wakasa-Morimoto C; Brown KW; Ferris R; Foster SA; Hazen RJ; Miki S; Suyama-Kagitani A; Kawauchi-Miki S; Taishi T; Kawasuji T; Johns BA; Underwood MR; Garvey EP; Sato A; Fujiwara T
Antimicrob Agents Chemother; 2011 Feb; 55(2):813-21. PubMed ID: 21115794
[TBL] [Abstract][Full Text] [Related]
18. Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase.
Vandegraaff N; Kumar R; Hocking H; Burke TR; Mills J; Rhodes D; Burrell CJ; Li P
Antimicrob Agents Chemother; 2001 Sep; 45(9):2510-6. PubMed ID: 11502522
[TBL] [Abstract][Full Text] [Related]
19. HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
Johnson AA; Marchand C; Pommier Y
Curr Top Med Chem; 2004; 4(10):1059-77. PubMed ID: 15193139
[TBL] [Abstract][Full Text] [Related]
20. Biochemical screening assays to identify HIV-1 integrase inhibitors.
Clynhens M; Smets A; Vereycken I; Van Loock M; Clayton R; Meersseman G; Goethals O
Methods Mol Biol; 2013; 1030():25-36. PubMed ID: 23821258
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]